Preparation of novel cinnamaldehyde derivative–BSA nanoparticles with high stability, good cell penetrating ability, and promising anticancer activity

Chang, Shuhua; Qin, Dawei; Wang, Lizhen; Zhang, Mengli; Yan, Rongjun; Zhao, Cuiyun

doi:10.1016/j.colsurfa.2021.126765

Cited by 15 publications

(17 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fourier transform infrared (FTIR) spectroscopy (Vertex 70 spectrometer, Bruker Co., Germany) and fluorescence spectroscopy (F-2700, Shimadzu Co., Japan) were applied to analyze the binding sites and variations in the protein structure. 34 Fluorescence quenching was estimated by the Stern-Volmer equation. 9…”

Section: Spectral Analysis Of the Interaction Between Proteins And Mg...mentioning

confidence: 99%

Adding exogenous protein relieves the toxicity of nanoparticles to anammox granular sludge by adsorption and the formation of eco-coronas

Wang

Zhang

et al. 2022

Environ. Sci.: Nano

View full text Add to dashboard Cite

show abstract

Section: Spectral Analysis Of the Interaction Between Proteins And Mg...mentioning

confidence: 99%

Adding exogenous protein relieves the toxicity of nanoparticles to anammox granular sludge by adsorption and the formation of eco-coronas

Wang

Zhang

et al. 2022

Environ. Sci.: Nano

View full text Add to dashboard Cite

show abstract

“…PC12 cells (1 × 10 5 ) were cultured (100 µl/well in 96-well plates) in Dulbecco's modified Eagle's medium supplemented with 10% fetal calf serum, 1% penicillin and streptomycin at 37°C, and 5% CO 2 and 95% air for 24 h (Chang et al, 2021).…”

Section: Cell Culturementioning

confidence: 99%

Enhanced Bioavailability of Dihydrotanshinone I–Bovine Serum Albumin Nanoparticles for Stroke Therapy

Ren

Feng

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Dihydrotanshinone I (DHT) is a natural component in Salvia miltiorrhiza and has been widely researched for its multiple bioactivities. However, poor solubility and biocompatibility of DHT limit its desirable application for clinical purposes. Herein, DHT was encapsulated with bovine serum albumin (BSA) to enhance bioavailability. Compared to free DHT, DHT–BSA NPs (nanoparticles) showed an improved solubility in normal saline and increased protection against hydrogen peroxide–induced oxidative damage in PC12 cells. In addition, DHT–BSA NPs administered by intravenous injection displayed a significant efficacy in the middle cerebral artery occlusion/reperfusion models, without any impact on the cerebral blood flow. In summary, DHT–BSA NPs show an enhanced bioavailability compared with free DHT and a successful penetration into the central nervous system for stroke therapy, demonstrating their application potential in cardio–cerebrovascular diseases.

show abstract

“…Various reports have shown its activity against different pathogens ( Neto et al, 2022 ). Further, it showed anti-cancer effects against various cancers ( Chang et al, 2021 ; Kumari and Singh, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

et al. 2022

View full text Add to dashboard Cite

Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties. Here, we have elucidated the anti-tumor effects of Cinnamomum zeylanicum extract (CZE) and its bioactive compound cinnamaldehyde (CIN) on oral cancer and elucidated underlying molecular mechanisms. Anti-tumor activities of CZE and CIN were demonstrated by various in vitro experiments on oral cancer cells (SCC-4, SCC-9, SCC-25). The cell proliferation, growth, cell cycle arrest, apoptosis, and autophagy were analyzed by MTT, clonogenic assay, propidium iodide, annexin-V-PI, DAPI, and acridine orange staining, respectively. The binding affinity of CIN towards dihydrofolate reductase and p38-MAP kinase alpha was analyzed by molecular docking. Western blot assay was performed to assess the alteration in the expression of various proteins. CZE and CIN treatment significantly inhibited the growth and proliferation of oral cancer cells in a dose-dependent manner. These treatments further induced apoptosis, cell cycle arrest, and autophagy. CZE and CIN inhibited the invasion and cytoplasmic translocation of NF-κB in these cell lines. CIN showed a high affinity to MAP kinase P38 alpha and dihydrofolate reductase with binding affinities of −6.8 and −5.9 kcal/mol, respectively. The cancer cells showed a decreased expression of various PI3k-AKT-mTOR pathways related to VEGF, COX-2, Bcl-2, NF-κB, and proteins post-treatment.

show abstract

Preparation of novel cinnamaldehyde derivative–BSA nanoparticles with high stability, good cell penetrating ability, and promising anticancer activity

Cited by 15 publications

References 37 publications

Adding exogenous protein relieves the toxicity of nanoparticles to anammox granular sludge by adsorption and the formation of eco-coronas

Adding exogenous protein relieves the toxicity of nanoparticles to anammox granular sludge by adsorption and the formation of eco-coronas

Enhanced Bioavailability of Dihydrotanshinone I–Bovine Serum Albumin Nanoparticles for Stroke Therapy

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

Contact Info

Product

Resources

About