Preparation of polymeric foams with a pore size gradient via Thermally Induced Phase Separation (TIPS)

Mannella, G. A.; Conoscenti, Gioacchino; Pavia, Francesco Carfì; Carrubba, Vincenzo La; Brucato, V.

doi:10.1016/j.matlet.2015.07.055

Cited by 55 publications

(26 citation statements)

References 13 publications

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“…In fact, addition of higher amounts of PEO to the membrane polymer dope resulted in increased membrane porosity and average pore size. Using TIPS, however, addition of additives is not needed as different pore sizes can be obtained by altering the quenching rate . In our case, a lower quenching rate will increase the pore size.…”

Section: Discussionmentioning

confidence: 99%

Fabricating porous, photo‐crosslinked poly(trimethylene carbonate) membranes using temperature‐induced phase separation

Pasman

Grijpma

Stamatialis

et al. 2016

Polymers for Advanced Techs

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The recent development of lungs‐on‐chips is a major advancement in lung disease research. However, the materials used for the membranes in these chips, e.g. poly(dimethyl siloxane) and silicon, are not ideal. This study uses the more biocompatible and mechanically favorable polymer poly(trimethylene carbonate) (PTMC). Porous membranes were made of high molecular weight linear PTMC (250,000 g/mol) via temperature‐induced phase separation with ethylene carbonate, followed by ultraviolet (UV)‐light crosslinking with pentaerythritol triacrylate and Irgacure 2959. Membrane morphology and crosslinking efficacy was investigated. Membranes with micrometer‐sized pores could be made. There was variation between the different membrane sides in terms of pore size and distribution. Cooling during UV‐light crosslinking resulted in more homogeneous membrane pores, both in size and distribution, and raised the gel content from 48% to 73%, which can be further enhanced by adjustment of the UV treatment or the amount of crosslinking agents. All membranes were highly permeable to water suggesting that nutrient transport, when used with cells, is not limited by the membranes. Here, we show the development of thin and porous PTMC membranes for lungs‐on‐chips, Transwell® inserts and other cell culturing applications. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Fabricating porous, photo‐crosslinked poly(trimethylene carbonate) membranes using temperature‐induced phase separation

Pasman

Grijpma

Stamatialis

et al. 2016

Polymers for Advanced Techs

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“…Conventional and modern scaffold fabrication technologies have been employed to devise single‐layer and multilayer porous scaffolds for osteochondral lesions. Freeze drying, particulate leaching, and gas foaming have a long history of ability to fabricate tissue engineering scaffolds (Mannella, Conoscenti, Carfì Pavia, Carrubba, & La Brucato, ; Q. Zhang, Lu, Kawazoe, & Chen, ). The processing variables in those methods can be adjusted to give rise to scaffold with graded internal architecture.…”

Section: Osteochondral Tissue Regenerationmentioning

confidence: 99%

A review on gradient hydrogel/fiber scaffolds for osteochondral regeneration

Khorshidi

Karkhaneh

2018

J Tissue Eng Regen Med

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Osteochondral tissue regeneration is a complicated field due to the distinct properties and healing potential of osseous and chondral phases. In a natural osteochondral region, the composition, mechanics, and structure vary smoothly from bony to cartilaginous phase. Therefore, a homogeneous scaffold cannot satisfy the complexity of the osteochondral matrix. In essence, a natural extracellular matrix is composed of fibrous proteins elongated into a gelatinous background. A hydrogel/fiber scaffold possessing gradient in both phases would be of the utmost interest to imitate tissue arrangement of a native osteochondral interface. However, there are limited research works that exploit hydrogel/fiber scaffolds for osteochondral restoration. In the present review, currently used fibrous or gelatinous scaffolds for osteochondral damages are discussed. Moreover, superiority of using gradient hydrogel/fiber composites for osteochondral regeneration and practical approaches to develop those scaffolds is debated.

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“…By taking advantage of the TIPS process, since the pore dimension is mainly dependent on the residence time in the metastable region [23], Mannella et al [24] proposed an experimental apparatus able to impose a different T vs. time pathway on two sides of a sample. In this way a gradient of pore dimension was obtained along the scaffold thickness in a single step, without requiring the junction of the multiple layers.…”

Section: Figurementioning

confidence: 99%

A Versatile Technique to Produce Porous Polymeric Scaffolds: The Thermally Induced Phase Separation (TIPS) Method

Conoscenti¹,

Carrubba²,

Brucato³

2017

Arch Chem Res

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Among the various scaffold fabrication techniques, thermally induced phase separation (TIPS) is one of the most versatile methods to produce porous polymeric scaffold and it has been largely used for its capability to produce highly porous and interconnected scaffolds. The scaffold architecture can be closely controlled by varying the process parameters, including polymer type and concentration, solvent/non-solvent ratio and thermal history. TIPS technique has been widely employed, also, to produce scaffolds with a hierarchical pore structure and composite polymeric matrix/inorganic filler foams.

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Preparation of polymeric foams with a pore size gradient via Thermally Induced Phase Separation (TIPS)

Cited by 55 publications

References 13 publications

Fabricating porous, photo‐crosslinked poly(trimethylene carbonate) membranes using temperature‐induced phase separation

Fabricating porous, photo‐crosslinked poly(trimethylene carbonate) membranes using temperature‐induced phase separation

A review on gradient hydrogel/fiber scaffolds for osteochondral regeneration

A Versatile Technique to Produce Porous Polymeric Scaffolds: The Thermally Induced Phase Separation (TIPS) Method

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