Preparation of polyvinyl alcohol/asiaticoside/chitosan membrane nano-composite using electrospinning technique for wound dressing

Raharjo, Arifin Budi; Putra, Richo Dwi Andika; Indayaningsih, Nanik; Srifiana, Yudi; Hardiansyah, Andri; Irmawati, Yuyun; Widodo, Henry; Destyorini, Fredina

doi:10.1063/5.0014545

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…Not only capacity of anti-aging in UV damaged cells as reported in the present study, but also capability against retinal degradation and ameliorate inflammation through Nrf2/HO-1 pathway and TLR4/NF-κB pathway, respectively ( 57 , 58 ). Furthermore, asiaticoside-contained foam dressing, nano-composite and nanofibrous scaffold have been developed for traumatic treatment, showing great potential of asiaticoside in wound healing ( 14 , 59 , 60 ). By taking advantage of nanocarriers, novel usages of asiaticoside could be expanded and more applications related to asiaticoside might be developed.…”

Section: Discussionmentioning

confidence: 99%

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Jiang

Zhou

2022

Exp Ther Med

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Section: Discussionmentioning

confidence: 99%

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Jiang

Zhou

2022

Exp Ther Med

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“…Similarly, because of its biocompatible, biodegradable and antimicrobial properties, and rosemary plant [28,29] has been used as a bioactive packaging material and to obtain nanofibers by electrospinning for use in the biomedical field. Many plant extracts such as aloe vera [30,31], thyme [10], grape seed [32], chamomile [33], green tea [34], grewia mollis [35], gotu kola [36], calendula [37], mangosteen [38], lavender [39] are mixed with different polymers and used in the production of nanofibers for use in the medical field.…”

Section: Herbal Extracts Used To Obtain Nanofibers By Electrospinning...mentioning

confidence: 99%

Production of Nanofibers from Plant Extracts by Electrospinning Method

Eroğlu¹

2022

Electrospinning - Material Technology of the Future

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The fact that different plants grow in each climate type, that each plant has different and many benefits, and that it can obtain bio-structured, sustainable, economic, and ecological products has increased the work of researchers in this field. The long-term toxicity and harmful side effects of herbal extracts are generally less compared to synthetic drugs. Studies on the production of nanofibrous membrane structures from plant extracts are relatively limited and are an emerging field. Herbal extracts have a positive effect in electrospinning applications with their biodiversity, ability to maintain biological functionality, and wound healing effects against pathogenic microorganisms. With the creation of nanofiber structures of plants obtained from natural sources, applications in fields such as wound healing, tissue engineering, drug release are increasing day by day.

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“…Asiaticoside in Centella asiatica L. (also known as Gotu kola) and β-sitosterol in Moringa oleifera have antioxidant activity, a potential active ingredient in anti-aging dosage forms. [18][19][20][21][22] Gotu kola contains vitamins C and B, with its main active ingredient being triterpenoid glycosides like asiatic acid, asiaticoside, madecassic acid, madecassoside, sitosterol, kaempferol, and polyacetylene compounds. 19 This plant is recognized for its antioxidant and ethanol extract antioxidant activity against the DPPH free radical of 79.49 (%), corresponding to 6.059±0.022 mg ascorbic acid equivalent/g DW has been reported.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Antioxidant Activity Test of Centella asiatica Herba Extract and Moringa oleifera Leaves Extract as An Anti-Aging Emulgel

2024

TJNPR

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Typically, topical formulations like creams and gels are chosen to address skin issues such as premature aging. These formulations, including creams, gels, and face masks, are commonly used by the public. Generally, these dosage forms' formulation and physical quality should conform to standards and exhibit good physical quality. However, these topical dosage forms still have their limitations. Gels struggle with delivering hydrophobic drugs, which are easily lost when exposed to sweat or water. 8 Creams require a heating process during manufacturing and can break down if the formula is incorrect, 9 while ointment (hydrocarbon-based) shows greasiness as well as phase inversion. 10 An innovative approach is needed to address the limitations of the previously mentioned topical dosage forms, such as utilizing an emulgel-a gel-based emulsion. 8 Emulgel formation utilizes a combination of hydrogel and emulsion systems to create concrete structures that enhance the stability of the bioactive ingredient or delivery method. Other advantages of emulgel are incorporating hydrophobic drugs, better loading capacity, better stability, production feasibility, low dosage form cost, and improved patient compliance. [11][12][13][14] Common excipients used in emulgel include Carbopol 940 and stearic acid. Frequently utilized as a gelling agent, Carbopol quickly disperses in water at room temperature, exhibits a wide viscosity range, and achieves the desired gel base viscosity with only a small concentration. 15,16 On the other hand, stearic acid is a versatile excipient commonly used in topical formulations and widely used in cosmetics. Stearic acid is frequently used in cream formulations when partially neutralized with alkalis or triethanolamine. This results in the generation of a creamy base when combined with 5-15 times its weight in aqueous liquid. The appearance and plasticity of the cream depend on the proportion of alkali utilized. 16 To maintain the stability of emulgel preparations, it is crucial to use the appropriate excipients at

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Preparation of polyvinyl alcohol/asiaticoside/chitosan membrane nano-composite using electrospinning technique for wound dressing

Cited by 5 publications

References 4 publications

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway

Production of Nanofibers from Plant Extracts by Electrospinning Method

Formulation and Antioxidant Activity Test of Centella asiatica Herba Extract and Moringa oleifera Leaves Extract as An Anti-Aging Emulgel

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