Preparation of polyvinyl alcohol hydrogel containing bacteriophage and its evaluation for potential use in the healing of skin wounds

Boggione, Delaine Meireles Gouvêa; Santos, Igor José Boggione; Souza, Saymon Menezes de; Mendonça, Regina Célia Santos

doi:10.1016/j.jddst.2021.102484

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…To improve phage stability, encapsulation can be employed to increase the retention time of phages, to contain phage concentration at a therapeutically effective level, and to control the time of release [ 7 ] but also its stability. For gastrointestinal infections, phages were mostly encapsulated in liposomes [ 13 , 14 ], and for other infections such as burn wounds, biofilms on implants, and root canal infections, phages were encapsulated in microparticles (d = 8.0 ± 4.5 µm) [ 15 ], scaffolds [ 16 ], and hydrogels [ 17 , 18 , 19 ], in materials such as biopolymers [ 20 ], synthetic and semisynthetic polymers, and inorganic materials [ 16 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

et al. 2021

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The role of bacteriophage therapy in medicine has recently regained an important place. Oral phage delivery for gastrointestinal treatment, transport through the stomach, and fast release in the duodenum is one of such applications. In this work, an efficient polyHIPE/hydrogel system for targeted delivery of bacteriophages with rapid release at the target site is presented. T7 bacteriophages were encapsulated in low crosslinked anionic nanocellulose-based hydrogels, which successfully protected phages at pH < 3.9 (stomach) and completely lost the hydrogel network at a pH above 3.9 (duodenum), allowing their release. Hydrogels with entrapped phages were crosslinked within highly porous spherical polyHIPE particles with an average diameter of 24 μm. PolyHIPE scaffold protects the hydrogels from mechanical stimuli during transport, preventing the collapse of the hydrogel structure and the unwanted phage release. On the other hand, small particle size, due to the large surface-to-volume ratio, enables rapid release at the target site. As a consequence, a fast zero-order release was achieved, providing improved patient compliance and reduced frequency of drug administration. The proposed system therefore exhibits significant potential for a targeted drug delivery in medicine and pharmacy.

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Section: Introductionmentioning

confidence: 99%

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

et al. 2021

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“…This behavior indicates that at pH 5, the adsorption system is less efficient than at pH 6 and 7. The adsorption capacity of HG is similar in this pH range (5)(6)(7)(8), and the adsorption capacity of HG-Fe increases from pH 5 to 7 and then decreases due to the presence of hydroxyl groups.…”

Section: Effect Of Phmentioning

confidence: 71%

“…They have huge quantities of water in the polymeric network, which prevent the entire system from solubilizing despite their high affinity for water. The polymeric structure of hydrogels can be modified to have a desired functionality to allow their use in many fields [1][2][3], such as drug delivery [4][5], contaminants removal [6][7], scaffolds in tissue engineering [8][9], contact lenses [10][11], pH sensors [12], biosensors [13], spinal cord injury (SCI) [14],…”

Section: Introductionmentioning

confidence: 99%

Removal of fluoride ions from aqueous solutions on unmodified and iron-modified hydrogels

Rosendo-González,

Gutiérrez-Segura,

Solache-Rios

et al. 2024

J Polym Res

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Unmodified and iron-modified hydrogels were synthesized from polyvinyl alcohol and polyvinylpyrrolidone; these materials were used for the adsorption of fluoride ions from an aqueous solution. The structural and morphological characteristics of the unmodified (HG) and modified (HG-Fe) hydrogels were determined by means of hydration percentage, point of zero charge (PZC), infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and dispersive energy spectroscopy (EDS). The parameters considered in the adsorption processes were contact time, pH, fluoride concentration and dosage. The kinetic data were obtained at an initial pH of 6.7 and were best fitted to the Elovich model (R 2 = 0.994); the adsorption capacity was higher for HG-Fe than HG. The data obtained at pH 5 were adjusted to the Lagergren equation indicating physical adsorption. The capacities of both materials (HG and HG-Fe) were similar, and the equilibrium time was shorter for HG than HG-Fe. The isotherms were best fitted to the Langmuir model, indicating homogeneous materials. The maximum adsorption capacities were similar for both adsorbents (HG-Fe and HG), and the thermodynamic parameters showed that the processes are exothermic.

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“…(P. vulgaris, P. mirabilis), Klebsiella spp. (K. pneumoniae, K. oxytoca), Pseudomonas aeruginosa and Escherichia coli Polyvinyl alcohol (PVA), aqueous solution of bacteriophages "Complex Pyobacteriophage" and succinic acid; Polyvinyl alcohol (PVA) and aqueous solution of bacteriophages "Complex Pyobacteriophage" and lidocaine; Polyvinyl alcohol (PVA) and aqueous solution of bacteriophages "Complex Pyobacteriophage" and succinic acid and lidocaine [103] Escherichia coli Polyvinyl alcohol (PVA) hydrogel and bacteriophage [112] Acinetobacter baumannii Sodium alginate, choline oleate and lytic bacteriophages [105] Escherichia coli Sodium alginate, gelatin, and hyaluronic acid for encapsulating acid fibroblast growth factor (aFGF) and bacteriophages [113] Pseudomonas aeruginosa Polycaprolactone (PCL) nanofibers (non-woven textile) and bacteriophages [110] Staphylococcus aureus Beta-glucan (BG), arabinogalactan, gums, and bacteriophages [114] Enterococcus faecalis Alginate-nanohydroxyapatite hydrogel and phages [115]…”

Section: Staphylococcus Aureusmentioning

confidence: 99%

Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art

Vila,

Balcão,

Balcão

2024

Pharmaceutics

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This review aims at presenting the main strategies that are currently available for the delivery of bacteriophages to combat bacterial infections in humans, animals, and plants. It can be seen that the main routes for phage delivery are topical, oral, systemic, and airways for humans. In animals, the topical and oral routes are the most used. To combat infections in plant species, spraying the plant’s phyllosphere or drenching the soil are the most commonly used methods. In both phage therapy and biocontrol using phages, very promising results have been obtained so far. However, more experiments are needed to establish forms of treatment and phage doses, among other parameters. Furthermore, in general, there is a lack of specific standards for the use of phages to combat bacterial infections.

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Preparation of polyvinyl alcohol hydrogel containing bacteriophage and its evaluation for potential use in the healing of skin wounds

Cited by 10 publications

References 27 publications

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

Removal of fluoride ions from aqueous solutions on unmodified and iron-modified hydrogels

Phage Delivery Strategies for Biocontrolling Human, Animal, and Plant Bacterial Infections: State of the Art

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