Preparation of protein imprinted materials by hierarchical imprinting techniques and application in selective depletion of albumin from human serum

Liu, Jinxiang; Deng, Qiling; Tao, Dingyin; Yang, Kaiguang; Zhang, Lihua; Liang, Zhen; Zhang, Yukui

doi:10.1038/srep05487

Cited by 61 publications

(37 citation statements)

References 25 publications

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“…The introduction of these ingenious technologies into the molecular imprinting strategy will open up new opportunities for interesting applications. 77 However, the surface area of the substrate is so limited that the total amount of the resultant imprinting cavities is always very small. Therefore, finding and preparing large surface area substrates is an important task to attain better performances in surface imprinting.…”

Section: Ingenious Mit For Mipsmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Section: Ingenious Mit For Mipsmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…A brief synopsis of the different types of protein and biomacromolecular surface‐imprinted monoliths and particles/beads is shown in Tables and , respectively, including the various surface imprinting strategies and characterization techniques that have been utilized.…”

Section: Imprinting Of Peptides and Proteins For The Use In Solid‐phamentioning

confidence: 99%

Advances in the development of molecularly imprinted polymers for the separation and analysis of proteins with liquid chromatography

Boysen

2018

J of Separation Science

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This review documents recent advances in the design, synthesis, characterization, and application of molecularly imprinted polymers in the form of monoliths and particles/beads for the use in the separation and analysis of proteins with solid‐phase extraction or liquid chromatography. The merits of three‐dimensional molecular imprinting, whereby the molecular template is randomly embedded in the polymer, and two‐dimensional imprinting, in which the template is confined to the surface, are described. Target protein binding can be achieved by either using the entire protein as a template or by using a protein substructure as template, that is, a peptide, as in the "epitope" approach. The intended approach and strategy then determine the choice of polymerization method. A synopsis has been provided on methods used for the physical, chemical, and functional characterizations and associated performance evaluations of molecularly imprinted and nonimprinted control polymers, involving a diverse range of analytical techniques commonly used for low and high molecular mass analytes. Examples of recent applications demonstrate that, due to the versatility of imprinting methods, molecularly imprinted monoliths or particles/beads can be adapted to protein extraction/depletion and separation procedures relevant to, for example, protein biomarker detection and quantification in biomedical diagnostics and targeted proteomics.

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“…It is noteworthy that the surface coverage of silica beads had a significant effect on the selectivity; the highest selectivity was obtained when the template surface coverage was about 20%, because in higher amounts, homogeneous monolayers did not form owing to enhanced protein–protein interactions. The resultant hierarchically imprinted polymer had the advantage of high adsorption capacity and affinity, fast adsorption kinetics, and good synthesis reproducibility …”

Section: Molecular Imprinting Of Proteinsmentioning

confidence: 99%

Biomacromolecule template-based molecularly imprinted polymers with an emphasis on their synthesis strategies: a review

Zahedi

Ziaee

Abdouss

et al. 2016

Polym. Adv. Technol.

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Molecular imprinting is an efficient tool for generating synthetic acceptors with specific recognition sites, which are mimed from template structures via polymerization. The final products of this strategy lead to high‐performance polymers with active recognition sites for a range of various applications in terms of extraction and separation, characterization and recognition, biomedicine, biosensors, and drug delivery. Molecular imprinting of biomacromolecules synthesizes a series of matrices that may be referred to as biomolecularly imprinted polymers (BMIPs). In this review article, an overview of different methods for fabricating BMIPs with an emphasis on novel polymerization schemes along with potential challenges is discussed. Additionally, selected applications of BMIPs will be briefly highlighted derived from the latest research papers. Copyright © 2016 John Wiley & Sons, Ltd.

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Preparation of protein imprinted materials by hierarchical imprinting techniques and application in selective depletion of albumin from human serum

Cited by 61 publications

References 25 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Advances in the development of molecularly imprinted polymers for the separation and analysis of proteins with liquid chromatography

Biomacromolecule template-based molecularly imprinted polymers with an emphasis on their synthesis strategies: a review

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