Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles

Lippacher, A.; Müller, Rainer H.; Mäder, Karsten

doi:10.1016/s0378-5173(00)00623-2

Cited by 119 publications

(40 citation statements)

References 4 publications

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“…This means that SLN systems are more elastic than NLC systems of compared lipid content. The decrease in viscosity observed with increase in applied frequency is also typical for viscoelastic solids and can be found for standard topical dosage forms [21].…”

Section: Oscillation Frequency Sweep Testsupporting

confidence: 54%

“…As a result, liquid solid lipid dispersions possess a low viscosity (approximately 100 mPa s) and a yield value of practically zero [15]. Therefore, the liquid solid lipid dispersions usually have to be incorporated in convenient topical dosage forms like hydrogels or creams to obtain a topical application form having the desired semisolid consistency [21,24]. Incompatibilities with ingredients from the hydrogel or cream may occur due to interactions between the gel forming polymer, emulsifying agents, lipid and drug.…”

Section: Continuous Shear Rheometrymentioning

confidence: 99%

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Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Souto

Wissing

Barbosa

et al. 2004

European Journal of Pharmaceutics and Biopharmaceutics

201

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Aqueous dispersions of lipid nanoparticles are being investigated as drug delivery systems for different therapeutic purposes. One of their interesting features is the possibility of topical use, for which these systems have to be incorporated into commonly used dermal carriers, such as creams or hydrogels, in order to have a proper semisolid consistency. For the present investigation four different gel-forming agents (xanthan gum, hydroxyethylcellulose 4000, Carbopol w 943 and chitosan) were selected for hydrogel preparation. Aqueous dispersions of lipid nanoparticles-solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)-made from tripalmitin were prepared by hot high pressure homogenization and then incorporated into the freshly prepared hydrogels. NLC differ from SLN due to the presence of a liquid lipid (Miglyol w 812) in the lipid matrix. Lipid nanoparticles were physically characterized before and after their incorporation into hydrogels. By means of rheological investigations it could be demonstrated that physical properties of the dispersed lipid phase have a great impact on the rheological properties of the prepared semisolid formulations. By employing an oscillation frequency sweep test, significant differences in elastic response of SLN and NLC aqueous dispersions could be observed. q

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Section: Oscillation Frequency Sweep Testsupporting

confidence: 54%

Section: Continuous Shear Rheometrymentioning

confidence: 99%

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Souto

Wissing

Barbosa

et al. 2004

European Journal of Pharmaceutics and Biopharmaceutics

201

View full text Add to dashboard Cite

show abstract

“…The difference in surfactant type might be responsible for such a result as well, 34 since most topical dosage forms are formulated in the semisolid form. Since lipidic nanoparticles are gaining interest among topical delivery systems, 35 few studies are focusing on the stability of SLN and NLC particles after incorporation into hydrogels. Souto et al prepared hydrogels with different gel-forming agents (xanthan gum, Chitosan, Carbopol, and hydroxyethyl cellulose) in different concentrations containing 5% SLN and NLC dispersion in order to evaluate their stability before and after incorporation into hydrogel formulations.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Bahari¹,

Hamishehkar²

2016

Adv Pharm Bull

181

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“…11,[23][24][25] The study of the flow properties (ie, consistency) of semisolid formulations gives information about their rheological behavior, which allows estimation of their suitability for the proposed application. These studies can be performed in viscometers, and the respective flow behavior can be assessed by analysis of the plots of shear stress versus shear rate.…”

Section: Rheological Measurementsmentioning

confidence: 99%

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

Tichota¹,

Silva²,

Lobo³

et al. 2014

IJN

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Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used in both dermatological and cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique, since the former constitute well-established systems for dermal delivery. The aim of this work was to develop a topical formulation of argan oil NLCs to improve skin hydration. Firstly an NLC dispersion was developed and characterized, and afterward an NLC-based hydrogel was prepared. The in vivo evaluation of the suitability of the prepared formulation for the proposed application was assessed in volunteers, by measuring different skin-surface parameters for 1 month. An argan oil NLC-based hydrogel formulation was successfully prepared and characterized. Moreover, the entrapment of the NLCs in the hydrogel net did not affect their colloidal sizes. Additionally, it was observed that this formulation precipitated an increase in skin hydration of healthy volunteers. Therefore, we concluded that the preparation of NLC systems using argan oil as the liquid lipid is a promising strategy, since a synergistic effect on the skin hydration was obtained (ie, NLC occlusion plus argan oil hydration).

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Preparation of semisolid drug carriers for topical application based on solid lipid nanoparticles

Cited by 119 publications

References 4 publications

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

Evaluation of the physical stability of SLN and NLC before and after incorporation into hydrogel formulations

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration

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