Preparation of Supramolecular Hydrogels Containing Poloxamers and Methyl-β.-cyclodextrin

Thermosensitive in situ nanogel as ophthalmic delivery system of curcumin: development, characterization, in vitro permeation and in vivo pharmacokinetic studies

“…Poloxamer 407 consisting of higher ratio of hydrophobic poly(propylene oxide) units/hydrophilic poly(ethylene oxide) units per mole compared to Poloxamer 188 could decrease the hydrophobic interaction between each Poloxamer micelle. Therefore, the solution-gel transition of the system was lower 28 . However, the solution-gel transition temperature of the formulation should be higher than the room temperature to avoid refrigeration.…”

Supramolecular cyclodextrin-based drug nanocarriers

“…hydroxypropyl-βCD (HPβCD) or methyl-βCD (MβCD)) leads to a competition for the cavity of CD that may cause the 55 displacement of the drug as the polypseudorotaxane is formed. 89,169,170 To overcome the above reported problems, different strategies to incorporate CDs into micellar systems are being explored. CDs are called to play three different roles: i) CDs reversibly form 60 complexes with hydrophobic groups, which can be broken and reformed as a function of a variety of stimuli; 13,171 ii) CDs act as host of macromolecular guests creating poly(pseudo)rotaxanes, 172,173 which can lead to supramolecular polymer micelles; 174 and iii) CDs can serve as starting cores to 65 graft amphiphilic polymers and form star-shaped unimolecular micelles 175 or block copolymer micelles.…”