Preparation of trivalent vaccine against lumpy skin disease using different capripox viral strain

Kafafy, M; Soally, S El; Aboul-Soud, Emad; Zaghloul, Hosam; Mikhael, Christine A.

doi:10.21608/vmjg.2018.155986

Cited by 4 publications

(5 citation statements)

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“…This may partly be attributed to the nature of some cattle breeds or the type of vaccine used 67, 68 . In a study by Aboul Soud et al , no serological response was induced in cattle vaccinated with Romania strain while a trivalent Capripox vaccine (made up of SP Romania, GTPV Held and KSGP 0180) induced antibodies in 66% of vaccinated animals 66 . The mechanism underlying the protection of vaccinated animals do not developing antibodies and/or CMI (Lymphoproliferation/IFN response) at the time of challenge needs further investigation.…”

Section: Discussionmentioning

confidence: 94%

“…With the reasons unknown, protection from virulent LSDV in the absence of detectable anti-LSDV neutralizing antibodies has also been reported by other workers 21, 46, 57, 65 . While antibody response following vaccination of cattle with LSDV is variable (40-80%), the antibodies may be undetectable following administration of SPV vaccines 20, 66 . This may partly be attributed to the nature of some cattle breeds or the type of vaccine used 67, 68 .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

Kumar

Barua

Kumar

et al. 2022

Preprint

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Lumpy skin disease (LSD) was reported for the first time in India in 2019 and since then, it has become endemic. Since a homologous (LSD-virus based) vaccine was not available in the country, goatpox virus (GPV)-based heterologous vaccine was authorized for mass immunization against LSD in cattle. This study describes the evaluation of safety, immunogenicity and efficacy of a new live-attenuated LSD vaccine developed using an Indian field strain (LSDV/India/2019/Ranchi). The virus was attenuated by continuous passage (P=50) in Vero cells. The vaccine (50th LSDV passage in Vero cells, named as Lumpi-ProVacInd) did not induce any local or systemic reaction upon its experimental inoculation in calves (n=10). At day 30 post-vaccination (pv), the vaccinated animals were shown to develop antibody- and cell-mediated immune response and exhibited complete protection upon virulent LSDV challenge. We observed a minimum Neethling response (0.018% animals; 5 out of 26940 animals) of the vaccine in field trials among 26940 animals. There was no significant reduction in the milk yield in lactating animals (n=10108), besides there was no abortion or any other reproductive disorder in the pregnant animals (n=2889). Sero-conversion was observed in 85.18% animals in the field by day 30 pv.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

Kumar

Barua

Kumar

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…There are conflicting results regarding the development of humoral immune response following SPPV vaccine in cattle. No antibody response was detected in cattle following vaccination with SPPV vaccine [ 35 , 36 ]. However, a partial protection was recorded following challenge with the field strain [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…No antibody response was detected in cattle following vaccination with SPPV vaccine [ 35 , 36 ]. However, a partial protection was recorded following challenge with the field strain [ 35 , 36 ]. In contrast, some studies reported induction of both humoral cell-mediated responses were reported following vaccination of Romanian strain in cattle [ 37 – 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, some studies reported induction of both humoral cell-mediated responses were reported following vaccination of Romanian strain in cattle [ 37 – 39 ]. Humoral antibody response was detected in 2/3 of the vaccinated animals following vaccination with a trivalent vaccine containing SPPV Romania, GTPV and KSGP 0180 [ 36 ]. Humoral response was found to be acceptable after using 10 4.0 TCID50 of RM65 SPP vaccine [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

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Lumpy skin disease outbreaks in Egypt during 2017-2018 among sheeppox vaccinated cattle: Epidemiological, pathological, and molecular findings

et al. 2021

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The General Organization of the Veterinary Services in Egypt has adopted a sheeppox vaccination policy to control lumpy skin disease (LSD) in cattle. Over the course of the last two years, recurrent outbreaks were reported, with animals showing severe clinical signs and consequentially higher fatalities than that of cases reported in previous LSD outbreaks. A total of 1050 cattle showing typical clinical signs suggestive of LSD were clinically and pathologically investigated during 2017–2018. Skin nodules were collected and lumpy skin disease virus (LSDV) was screened in collected skin samples using PCR for the RPO-30 gene. Furthermore, the entire P32 protein coding gene was sequenced. Histopathology and immunohistochemistry of the skin nodules were also conducted. The obtained results showed an overall mortality rate of 6.86%. LSDV was confirmed in all the examined nodules as evidenced by immunohistochemistry and positive PCR amplification of the RPO30 gene. Sequencing analysis of the P32 gene revealed a highly conserved nature and genetic stability of the LSDV. The results of the present study show that the current vaccination protocol was not effective for a multitude of reasons. These results also serve as evidence for a strong recommendation of an amendment of homologous vaccine use aside from a complete coverage of cattle populations in order to reduce the incidence of LSD among cattle population in Egypt.

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Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

et al. 2023

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Preparation of trivalent vaccine against lumpy skin disease using different capripox viral strain

Cited by 4 publications

References 0 publications

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

Lumpy skin disease outbreaks in Egypt during 2017-2018 among sheeppox vaccinated cattle: Epidemiological, pathological, and molecular findings

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

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