Preperitoneal Fat Thicknesses, Lipid Profile, and Oxidative Status in Women With Uterine Fibroids

Vignini, Arianna; Clemente, Nicolò; Carpini, Giovanni Delli; Tassetti, Marta; Zagaglia, Giulia; Ciavattini, Andrea

doi:10.1177/1933719116689598

Cited by 18 publications

(18 citation statements)

References 40 publications

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“…SOD activity was evaluated using the DetectX ® Superoxide Dismutase (SOD) Colorimetric Activity Kit (K028-H1, Arbor Assays, Ann Arbor, MI, USA), following the manufacturer instructions instructions and previously reported [22]. Briefly, superoxide anion, generated from the conversion of xanthine and oxygen to uric acid and hydrogen peroxide by xanthine oxidase, converts water-soluble tetrazolium 1 (WST-1) salts to WST-1 formazan, a colored purple product that absorbs light at 450 nm.…”

Section: Methodsmentioning

confidence: 99%

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Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Mascitti¹,

Coccia²,

Vignini³

et al. 2019

Dentistry Journal

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The aim of this study was to compare the oral health status and salivary antioxidant system between patients diagnosed with anorexia nervosa (AN) and healthy controls. A total of 25 female AN patients and 25 matched healthy controls were enrolled. Clinical parameters and saliva samples were collected for each patient. Two questionnaires to investigate oral health and hygiene were administered. Superoxide Dismutase (SOD) activity and High Reactive Oxygen Species (hROS) were evaluated. Salivary concentration of SOD was significantly higher in subjects with AN compared with control group (1.010 ± 0.462 vs. 0.579 ± 0.296 U/mL; p = 0.0003). No significant differences between groups were identified for hROS (233.72 ± 88.27 vs. 199.49 ± 74.72; p = 0.15). Data from questionnaires indicated that, although most of the patients recognized the oral hygiene importance in maintaining a good oral health, more than half of them had poor oral hygiene. Altered biochemical composition of saliva in patients with AN could be interpreted as an effective defence mechanism against oxidative stress. Moreover, despite the discrepancy between clinical findings and perception of the oral health in AN population arose, the quality of life of these patients appears not to be significantly affected by their dental condition.

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Section: Methodsmentioning

confidence: 99%

“…The hROS levels were determined by the dye probe hydroxyphenyl fluorescein (Cell Technology Inc., Mountain View, CA, USA), which selectively detect hydroxyl radical and peroxynitrite, as already reported [22]. Who performed the salivary analysis was blinded to the clinical findings, medical history and to the results of the questionnaires.…”

Section: Methodsmentioning

confidence: 99%

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Mascitti¹,

Coccia²,

Vignini³

et al. 2019

Dentistry Journal

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“…Preservation of antioxidant balance and oxidative stress are important for a variety of benign and malignant conditions such as diabetes mellitus and the familial Mediterranean fever as well as for uterine fibroids (16,(29)(30)(31). Relationship between oxidative stress and uterine fibroids was demonstrated in studies regarding surgically removed leiomyomas and found clear interaction between mainly by lipid peroxidation and leiomyoma (32).…”

Section: Inhibition Of Oxidative Stress In the Cell By Amino Acids Anmentioning

confidence: 99%

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Çetinkaya

Ayral

Çeti̇nkaya

et al. 2019

Gynecol Obstet Reprod Med

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Objective: The mechanism of the leiomyoma formation process is still unknown. However, the menstrual cycle is associated with hypoxia, and ongoing hypoxia is associated with cellular events leading to the conversion of myometrial cells into uterine fibroids. After the hypoxic environment, the balance of cellular cytokines and growth factors changes. It was planned to evaluate the balance of oxidative agents and the role of oxidative stress in the formation of uterine fibroids.Study Design: The study was conducted in patients of gynecology outpatient clinic of Ankara Oncology Training and Research Hospital. Those volunteers with fibroids formed the study group, and the healthy ones were identified as the control group. A total of 64 subjects, 32 in both groups were included. The levels of catalase, ceruloplasmin, myeloperoxidase, native thiol, disulfide, and total thiol levels were investigated in groups.Results: Antioxidant parameters such as native thiol, disulfide, and total thiol levels were significantly decreased in uterine fibroid group. Catalase, ceruloplasmin, and myeloperoxidase levels were not statistically different between groups.Conclusion: Decrease in these antioxidant parameters showed that the hypoxia and the balance of oxidant and antioxidant substances changes may probably have associated with the pathophysiology of uterine fibroids.

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“…The investigators also showed no significant variation between cases and controls in serum total cholesterol and TG values. 13 Akinlua and Ojo, showed a raised level both cholesterol and triglycerides in fibroid patients (5.56±3.25mmol/L and 1.14±0.61mmol/L) respectively compared with the non-fibroid patients (4.13±0.64mmol/L and 0.5±0.51mmol/L) respectively. 16 Similar findings are also observed in our study.…”

Section: Resultsmentioning

confidence: 92%

“…A subject with low HDL-C had 3.62 (95% CI 1.44 to 9.23) times significantly higher risk of developing fibroid than that in women with normal level of HDL-C. Vignini et al mentioned that HDL-C maintained a significant correlation with the diagnosis of Uterine fibroid. 13 After adjustment by age, BMI and other potential factors, He et al found a negative correlation between HDL-C and uterine leiomyoma in the hysterectomy-confirmed group. 14 Similar findings also observed by Kong et al (2014).…”

Section: Resultsmentioning

confidence: 98%

Association of Dyslipidemia with Uterine Fibroid: A Case Control Study

Afruza¹,

Hossain²,

Jahan³

et al. 2020

TAJ: J of Teachers Assoc

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Background & objective: Uterine fibroid (UF) is the most common gynaecological neoplasm. Despite the major public health impact of UF, little is known about their association. Some studies focused on the similarities between the common biological mechanisms underlying the development of UF and atherosclerotic plaques. So, it is possible to hypothesize that same atherogenic risk factors, such as dyslipidemia may play a role in UF pathogenesis. This study was carried out to investigate the lipid profile in patients with UF and to analyze the association of dyslipidemia with UF. Materials & Methods: This case-control study was carried out in the outpatient and inpatient Department of Obstetrics & Gynaecology, BSMMU, Shahbag, Dhaka over a period of 12 months between March 2017 to February 2018. Participants were 100 in number and aged between 18 and 45 years. Cases consisted of 50 women with uterine fibroids diagnosed by ultrasonography attending the outpatient and inpatient department of obstetrics and gynaecology, BSMMU, having no previous hormonal treatment. A similar number of age matched women without UF visiting the same gynaecological outpatient clinic for routine reasons were recruited as controls. Women who were postmenopausal, pregnant, diagnosed cases of malignant diseases, diagnosed cases of hypertension, diabetes mellitus, thyroid disease, CLD and CKD and women undergoing hormonal therapy were excluded from the study. Fasting lipid profiles were determined in blood samples taken from each participant. Atherogenic index was also calculated. Chi-square test was used for testing statistical significance. Statistical significance was set at p < 0⋅05. Results: Women with UF were found to have significantly higher levels of serum TC, TG and significantly lower level of HDL-C compared to the controls (p<0.05). The mean atherogenic index was 4.30±1.41 in case group and 2.86±0.97 in control group. The difference was statistically significant (p<0.05) between two groups. Conclusion: There is an association between dyslipidemia and UF. Women with UF have higher atherogenic index compared to women without UF. TAJ 2020; 33(2): 100-106

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Preperitoneal Fat Thicknesses, Lipid Profile, and Oxidative Status in Women With Uterine Fibroids

Cited by 18 publications

References 40 publications

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Anorexia, Oral Health and Antioxidant Salivary System: A Clinical Study on Adult Female Subjects

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Association of Dyslipidemia with Uterine Fibroid: A Case Control Study

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