Prepubertal testicular tumors: a single-center experience of 44years

Akiyama, Sayaka; Ito, Kenichi; Kim, Woo Jin; Tanaka, Yukichi; Yamazaki, Yoji

doi:10.1016/j.jpedsurg.2016.02.042

Cited by 18 publications

(10 citation statements)

References 12 publications

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“…A partial orchiectomy was performed; the surgical aspect correlates with a benign tumor or a mature testicular teratoma in a prepubertal boy ( Figure 1). The latter diagnosis was well confirmed in the definitive histopathological analysis [1][2][3].…”

Section: Image Casementioning

confidence: 63%

A Rare Case of Global Developmental Delay with Ataxia Joubert Syndrome

Dasarwar¹,

Datla²

2016

Ann Clin Lab Res

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Section: Image Casementioning

confidence: 63%

A Rare Case of Global Developmental Delay with Ataxia Joubert Syndrome

Dasarwar¹,

Datla²

2016

Ann Clin Lab Res

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“…Immature teratomas were more likely to present at a younger age and have a lager tumor size than mature teratomas ( p < 0.001). Akiyama et al [2] reported that the age of patients with immature testicular teratoma ranged from 3 to 10 months (mean: 7 months) at surgery, which was significantly younger than the age of patients with mature testicular teratoma in the same period (mean: 19 months). Serum AFP is secreted by the yolk sac cells in the early fetal period and also by the proximal small intestine and the liver.…”

Section: Discussionmentioning

confidence: 99%

“…Immature testicular teratoma in children is significantly different from that in adults. Some clinicians propose that immature testicular teratoma in children is a benign tumor [1, 2, 9-13], and they suggest that adjunctive therapy is not needed after surgery for these children. Weissbach et al [14] first reported testis-preserving tumor enucleation in 1984.…”

Section: Discussionmentioning

confidence: 99%

“…In children, the incidence of testicular tumor is about 0.5–2.0 per 100,000, and testicular tumor accounts for 1–2% of solid tumors in children and 3% of all testicular tumors [1]. Testicular tumor in children is mainly germ cell tumor, and teratoma accounts for 31–65% of instances, of which immature teratoma accounts for 5–10% [1, 2]. Immature testicular teratoma is rare in children, and its treatments and biological characteristics are still poorly understood and controversial.…”

Section: Introductionmentioning

confidence: 99%

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Testis-Preserving Tumor Enucleation Is Applicable in Children with Immature Testicular Teratoma

Zhang

Song

et al. 2020

Urol Int

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Introduction: This study investigated the biological characteristics of immature testicular teratoma in children and explored the feasibility of testis-preserving tumor enucleation. Methods: We retrospectively reviewed the cases of 23 children who received a pathologic diagnosis of immature testicular teratoma between January 2005 and December 2018. Ages ranged from 16 days to 13 months (mean: 6 months and 5 days). Painless testicular enlargement was the main clinical manifestation, and the course of disease ranged from 20 days to 4 months (mean: 1.4 months). The tumor volume ranged from 1.5 × 1.2 × 0.5 to 6 × 5 × 4.5 cm. Elevated levels of alpha-fetoprotein were measured in 21 patients. Preoperative ultrasound examination showed a cystic/solid mass with calcification. Results: Excision of the affected testis was done in 10 patients and testis-preserving tumor excision in 13 patients. Postoperative chemotherapy was not employed. Nineteen patients were followed up for 1–10 years, and all showed disease-free survival without recurrence or metastasis. Conclusion: Immature testicular teratoma is found predominantly in children aged <1 year, and its biological characteristics are different from those in adults. Immature testicular teratoma is largely benign in children and can be managed by testis-preserving tumor enucleation, as for other benign tumors (such as mature teratoma). Postoperative monitoring and follow-up are necessary.

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“…The biological behavior of testicular teratomas differs between prepubertal and postpubertal boys, with the latter being more prone to developing malignant components (e.g., choriocarcinoma) and metastasis, something which is exceedingly rare in prepubertal testicular teratomas. Both mature and immature forms of testicular teratoma occur in children, although teratomas with somatic malignancies have also been described, where a somatic tumor such as a rhabdomyosarcoma grows invasively from within and replacing a germ cell tumor (Carver et al 2007;Akiyama et al 2016).…”

Section: Testicular Teratoma Epidemiology and Pathological Features Omentioning

confidence: 99%