Presence of functional TLR2 and TLR4 on human adipocytes

Bès-Houtmann, Sandrine; Roche, Régis; Hoareau, Laurence; Gonthier, Marie‐Paule; Festy, Franck; Caillens, H; Gasque, Philippe; d’Hellencourt, Christian Lefebvre; Césari, Maya

doi:10.1007/s00418-006-0230-1

Cited by 97 publications

(81 citation statements)

References 35 publications

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“…The expression of these receptors in immune cells is linked unequivocally to the detection of self from non-self [18]. However, an increasing number of reports indicate that TLRs are expressed and functional in non-immune, somatic cells such as adipose cells [22], mouse bone marrow derived mesenchymal stem cells (MSCs) [20] and human adipose tissue and bone marrow derived MSCs [23]. Several groups have also reported the expression of TLRs in ovarian tissues.…”

Section: Expression Of Tlrs In Non-immune Cellsmentioning

confidence: 99%

The involvement of the Toll-like receptor family in ovulation

Liu

Shimada

Richards

2008

J Assist Reprod Genet

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Introduction Ovulation is similar to an inflammatory response and is associated with increased production of prostaglandins as well as local growth regulatory factors. However, the expression and function of innate immune cell-related genes in non-immune cells within the ovary has been reported recently and provides a novel and important regulatory system during ovulation. Discussion Several members of the Toll-like receptor (TLR) surveillance system are expressed in granulosa cells and cumulus cells. These receptors can be activated by pathogens as well as endogenous ligands leading to the induction and release of potent cytokines and chemokines from cumulus cells. Conclusion These inflammatory factors exert potent effects on cumulus cell-oocyte expansion, ovulation, transport and fertilization indicating that ovulation is a more complex immune-inflammatory process than previously recognized.

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Section: Expression Of Tlrs In Non-immune Cellsmentioning

confidence: 99%

The involvement of the Toll-like receptor family in ovulation

Liu

Shimada

Richards

2008

J Assist Reprod Genet

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“…TLR4 is produced by macrophages and Kupffer cells and recent data have demonstrated its presence in murine [18] and human adipocytes [19].…”

Section: Introductionmentioning

confidence: 99%

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

et al. 2007

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Aims/hypothesis Inflammation is associated with obesity and has been implicated in the development of diabetes and atherosclerosis. During gram-negative bacterial infection, lipopolysaccharide causes an inflammatory reaction via toll-like receptor 4 (TLR4), which has an essential function in the induction of innate and adaptative immunity. Our aim was to determine what role TLR4 plays in the development of metabolic phenotypes during high-fat feeding. Materials and methods We evaluated metabolic consequences of a high-fat diet in TLR4 mutant mice (C3H/HeJ) and their respective controls. Results TLR4 inactivation reduced food intake without significant modification of body weight, but with higher epididymal adipose tissue mass and adipocyte hypertrophy. It also attenuated the inflammatory response and increased glucose transport and the expression levels of adiponectin and lipogenic markers in white adipose tissue. In addition, TLR4 inactivation blunted insulin resistance induced by lipopolysaccharide in differentiated adipocytes. Increased feeding efficiency in TLR4 mutant mice was associated with lower mass and lower expression of uncoupling protein 1 gene in brown adipose tissue. Finally, TLR4 inactivation slowed the development of hepatic steatosis, reducing the liver triacylglycerol content and also expression levels of lipogenic and fibrosis markers. Conclusions/interpretation TLR4 influences white adipose tissue inflammation and insulin sensitivity, as well as liver fat storage, and is important in the regulation of metabolic phenotype during a fat-enriched diet.

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“…Chronic inflammation is a common factor in the pathogenesis of insulin resistance and type 2 DM, the activation of TLR-4 by free fatty acids, observed in type 2 DM, and subsequent upregulation of intracellular inflammatory pathways establish a link between the innate immunity, insulin resistance, type 2 DM, and depression. Mature human adipocytes express the LPS receptor, TLR-4, with activation leading to the secretion of TNF-α [46]. Indeed, numerous studies consistently demonstrate that TLR-4 deficiency protects against the development of diet-induced obesity and insulin resistance [47].…”

Section: Discussionmentioning

confidence: 99%

Biochemical Studies of Hippocampal Gene Expression of Brain-Derived Neurotropic Factor and Toll-Like Receptor-4 in Diabetic Rats Exposed to Chronic Stress: Effects of Antidepressant Drugs

Aboul‐Fotouh

Hassan

Habib

et al. 2018

Asian J Pharm Clin Res

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Objective: Depression and diabetes are closely associated in a reciprocal manner, leading to significant morbidity and mortality with an evidence of a pro-inflammatory state underlying pathophysiology of both diseases. Unfortunately, little information is available about the effects of antidepressant drugs on hippocampal brain-derived neurotrophic factor (BDNF) and toll-like receptor-4 (TLR-4) expression in diabetes. Methods:We investigated the effect of chronic administration of fluoxetine (FLU) and imipramine (IMIP) on behavioral, metabolic, and inflammatory abnormalities in diabetic and non-diabetic rats exposed to chronic restraint stress (CRS).Results: Both diabetes and CRS induced depressive-like behavior which was more prominent in diabetic/depressed rats; this was reversed by chronic treatment with FLU and IMIP. Diabetic and non-diabetic rats exposed to CRS showed a significant increase in hippocampal expression of TLR-4 and pro-inflammatory cytokines alongside a decrease in BDNF expression. FLU and IMIP ameliorated these inflammatory abnormalities. Conclusion:Diabetes mellitus (DM) and chronic stress induced a depressive-like behavior associated with an increase in hippocampal expression of TLR-4, tumor necrosis factor-α, and interleukin-1ß with a significant correlation to decreased BDNF expression. FLU and IMIP showed comparable effects regards the improvement of depressive and inflammatory abnormalities associated with DM.

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Presence of functional TLR2 and TLR4 on human adipocytes

Cited by 97 publications

References 35 publications

The involvement of the Toll-like receptor family in ovulation

The involvement of the Toll-like receptor family in ovulation

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet

Biochemical Studies of Hippocampal Gene Expression of Brain-Derived Neurotropic Factor and Toll-Like Receptor-4 in Diabetic Rats Exposed to Chronic Stress: Effects of Antidepressant Drugs

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