Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management

Carmine, T.C.; Evans, Patricia; Bruchelt, Gernot; Evans, Robert W.; Handgretinger, Rupert; Niethammer, D; Halliwell, Barry

doi:10.1016/0304-3835(95)03852-n

Cited by 72 publications

(47 citation statements)

References 20 publications

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“…2. ND which has been suggested to cause oxidative damage to biomolecules in vivo (13)(14)(15)(16)(17)(18)(19). We found BDI in plasma of 19 out of 29 preterm infants, and the concentrations were comparable with those reported by Evans et al (13) but somewhat lower than those reported by other investigators for preterm infants (14,15).…”

Section: Fig 1 Ascorbic Acid Oxidation and Cholesteryl Ester Hydropsupporting

confidence: 85%

“…A similar interpretation was suggested by Gutteridge et al (17), who were unable to detect hydroxyl radical formation in serum of a hemochromatosis patient containing 19.4 M BDI, a very high concentration of BDI. It is interesting to note that numerous studies have reported hydroxyl radical formation and/or stimulation of lipid peroxidation by plasma or other biological fluids containing BDI (16,17,19,40), but all of these studies have used diluted or ultrafiltered samples. Such conditions significantly alter the protein concentration and antioxidant capacity of these fluids and also lead to the redistribution of iron (18).…”

Section: Fig 1 Ascorbic Acid Oxidation and Cholesteryl Ester Hydropmentioning

confidence: 99%

“…Therefore, BDI has been suggested to contribute to oxidative damage in vivo (13)(14)(15)(16)(17)(18)(19). BDI has also been detected in patients with iron-overload such as homozygous hemochromatosis (17,18) and in patients suffering from rheumatoid arthritis (16) or undergoing chemotherapy (19).…”

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confidence: 99%

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Antioxidant Activity of Vitamin C in Iron-overloaded Human Plasma

Berger¹,

Polidori²,

Dabbagh³

et al. 1997

Journal of Biological Chemistry

196

102

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Vitamin C (ascorbic acid, AA) can act as an antioxidant or a pro-oxidant in vitro, depending on the absence or the presence, respectively, of redox-active metal ions. Some adults with iron-overload and some premature infants have potentially redox-active, bleomycin-detectable iron (BDI) in their plasma. Thus, it has been hypothesized that the combination of AA and BDI causes oxidative damage in vivo. We found that plasma of preterm infants contains high levels of AA and F 2 -isoprostanes, stable lipid peroxidation end products. However, F 2 -isoprostane levels were not different between those infants with BDI (138 ؎ 51 pg/ml, n ‫؍‬ 19) and those without (126 ؎ 41 pg/ml, n ‫؍‬ 10), and the same was true for protein carbonyls, a marker of protein oxidation (0.77 ؎ 0.31 and 0.68 ؎ 0.13 nmol/mg protein, respectively). Incubation of BDI-containing plasma from preterm infants did not result in detectable lipid hydroperoxide formation ( 10 nM cholesteryl ester hydroperoxides) as long as AA concentrations remained high. Furthermore, when excess iron was added to adult plasma, BDI became detectable, and endogenous AA was rapidly oxidized. Despite this apparent interaction between excess iron and endogenous AA, there was no detectable lipid peroxidation as long as AA was present at >10% of its initial concentration. Finally, when iron was added to plasma devoid of AA, lipid hydroperoxides were formed immediately, whereas endogenous and exogenous AA delayed the onset of iron-induced lipid peroxidation in a dose-dependent manner. These findings demonstrate that in iron-overloaded plasma, AA acts an antioxidant toward lipids. Furthermore, our data do not support the hypothesis that the combination of high plasma concentrations of AA and BDI, or BDI alone, causes oxidative damage to lipids and proteins in vivo.

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Section: Fig 1 Ascorbic Acid Oxidation and Cholesteryl Ester Hydropsupporting

confidence: 85%

Section: Fig 1 Ascorbic Acid Oxidation and Cholesteryl Ester Hydropmentioning

confidence: 99%

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Antioxidant Activity of Vitamin C in Iron-overloaded Human Plasma

Berger¹,

Polidori²,

Dabbagh³

et al. 1997

Journal of Biological Chemistry

196

102

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“…Mingwei et al suggested that glycated proteins whose concentration is high in diabetics, do not only bind to iron and copper with higher affinity but also have the tendency to extract the iron from the traditional iron carriers [23]. In case of cancer patients undergoing for chemotherapy the reasons for the existence of NTBI are due to temporary shutdown of bone marrow and associated reduced demand of iron [24][25][26][27]. The other clinical conditions in which the presence of NTBI is indicated are acute coronary syndrome, liver disease, end stage kidney disease patients who are undergoing dialysis, in chronic alcoholics, myelodysplastic syndrome etc.…”

Section: Sources and Status Of Ntbi In Circulationmentioning

confidence: 99%

Non Transferrin Bound Iron: Nature, Manifestations and Analytical Approaches for Estimation

Patel

Ramavataram

2012

Ind J Clin Biochem

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“…Surprisingly, NTBI was also detected in some patients with partially saturated transferrin [5,11], a finding recently confirmed using a HPLC-based assay [12][13][14]. NTBI is also present in patients receiving chemotherapy, a phenomena resulting from the temporary 'shutdown' of the bone marrow and the associated reduction of the demand of transferrin-bound iron [15][16][17][18].…”

Section: Introductionmentioning

confidence: 89%

Nature of nontransferrin‐bound iron

Hider

2002

Eur J Clin Investigation

128

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Nontransferrin-bound iron is now recognized to exist by many workers. It is present in the serum of patients suffering from a wide range of disease states and may be induced by certain therapeutic treatments. The chemical nature of this iron pool is unknown but almost certainly it is a multicomponent pool including a considerable proportion of protein-bound iron.Methods are required to separate and quantify these different components. The biological properties of the individual isoforms need to be established; it is possible that some forms are relatively nontoxic, while others are highly toxic. This paper reviews what is known about the nature of nontransferrin-bound iron and describes the methods currently available to quantify this important serum component.

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Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management

Cited by 72 publications

References 20 publications

Antioxidant Activity of Vitamin C in Iron-overloaded Human Plasma

Antioxidant Activity of Vitamin C in Iron-overloaded Human Plasma

Non Transferrin Bound Iron: Nature, Manifestations and Analytical Approaches for Estimation

Nature of nontransferrin‐bound iron

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