Presence of Macrolide‐Lincosamide‐Streptogramin B and Tetracycline Antimicrobials in Swine Waste Treatment Processes and Amended Soil

Zilles, Julie L.; Shimada, Toshio; Jindal, Archana; Robert, M.; Raskin, Lutgarde

doi:10.2175/106143005x41627

Cited by 47 publications

(28 citation statements)

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“…Antimicrobials added to animal feed are not completely absorbed during digestion, resulting in their presence in manure (Heuer et al, 2011). The presence and activity of antimicrobials in manure can select for antimicrobial resistant bacteria, even at low antimicrobial concentrations (Knapp et al, 2008) and antimicrobials, ARGs, and resistant bacteria can enter the environment through a variety of pathways including agricultural wastewater (Wantanabe et al, 2010;Zhang et al, 2013) or land applied animal manure (Zilles et al, 2005;Pei et al, 2006;Heuer et al, 2011;Joy et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Fate of antimicrobials and antimicrobial resistance genes in simulated swine manure storage

Joy

Snow

et al. 2014

Science of The Total Environment

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Hunt, Shannon L., "Fate of antimicrobials and antimicrobial resistance genes in simulated swine manure storage" (2014 H I G H L I G H T S• Decay rates were determined for antimicrobials in anaerobic swine manure slurry.• Decreases in tet and erm resistance genes were observed.• Reductions in tet genes corresponded with reduced concentrations of chlortetracycline.• Compounds in addition to parent antimicrobial may exert selective pressure for erm resistance. The behavior of three antibiotics (bacitracin, chlortetracycline, and tylosin) and two classes of antibiotic resistance genes (ARGs), tet and erm, were monitored in swine manure slurry under anaerobic conditions. First-order decay rates were determined for each antibiotic with half-lives ranging from 1 day (chlortetracycline) to 10 days (tylosin). ARGs were monitored in the swine manure slurry, and losses of approximately 1 to 3 orders of magnitude in relative abundance were observed during the 40 day storage period. First-order degradation profiles were observed for chlortetracycline and its corresponding resistance genes, tet(X) and tet(Q). Tylosin was degraded to approximately 10% of the starting concentration by day 40; however, the relative abundance of erm(B) remained at 50-60% of the initial relative abundance while the relative abundance of erm(F) decreased by 80-90%, consistent with tylosin. These results indicate that tet resistance genes respond primarily to chlortetracycline antimicrobials, and may be lost when the parent tetracycline compound is degraded. In contrast, erm(B) resistance gene may respond to a range of antimicrobials in animal manure, and may persist despite losses of tylosin.

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Section: Introductionmentioning

confidence: 99%

Fate of antimicrobials and antimicrobial resistance genes in simulated swine manure storage

Joy

Snow

et al. 2014

Science of The Total Environment

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“…Waste streams from hospitals, animal husbandry, and pharmaceutical production facilities contain elevated concentrations of antimicrobials (Campagnolo et al, 2002;Kummerer, 2001;Zilles et al, 2005) and are commonly treated in systems that rely on biological processes. Acceptable treatment performance has been reported in anaerobic lagoons treating manure with concentrations of antimicrobials that would inhibit sensitive microorganisms (Jindal et al, 2006;Zilles et al, 2005), but the mechanism(s) for maintaining biological activity in the presence of antimicrobials and the associated questions of how and when antimicrobial resistance develops are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Shimada

Zilles

et al. 2010

Biotech & Bioengineering

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Morgenroth, Eberhard; and Raskin, Lutgarde, "Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor" (2010). Civil Engineering Faculty Publications. 37. http://digitalcommons.unl.edu/civilengfacpub/37 AbstractThe effects of the antimicrobial tylosin on a methanogenic microbial community were studied in a glucosefed laboratory-scale anaerobic sequencing batch reactor (ASBR) exposed to stepwise increases of tylosin (0, 1.67, and 167 mg/L). The microbial community structure was determined using quantitative fluorescence in situ hybridization (FISH) and phylogenetic analyses of bacterial 16S ribosomal RNA (rRNA) gene clone libraries of biomass samples. During the periods without tylosin addition and with an influent tylosin concentration of 1.67 mg/L, 16S rRNA gene sequences related to Syntrophobacter were detected and the relative abundance of Methanosaeta species was high. During the highest tylosin dose of 167 mg/L, 16S rRNA gene sequences related to Syntrophobacter species were not detected and the relative abundance of Methanosaeta decreased considerably. Throughout the experimental period, Propionibacteriaceae and high GC Gram-positive bacteria were present, based on 16S rRNA gene sequences and FISH analyses, respectively. The accumulation of propionate and subsequent reactor failure after long-term exposure to tylosin are attributed to the direct inhibition of propionate-oxidizing syntrophic bacteria closely related to Syntrophobacter and the indirect inhibition of Methanosaeta by high propionate concentrations and low pH.

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“…Not only variation in doses (a function of dosage and body weight) and excretion factors, dilution, degradation, slurry application rates and soil variability, but also factors such as representative sampling in slurry and soil, and field residue history, complicate the validation of this part of the model. A recent study from the USA confirms this conclusion (Zilles et al, 2005). It can be concluded that slurry or nutrient concentrations should be related to a realistic time frame in which the contaminated slurry is produced and diluted in order to optimise the worst case predictions; the available field data do not allow for validation of the parameter selection in the models; and that field concentrations may vary a factor 30 within one field.…”

Section: Discussionmentioning

confidence: 99%

Validation of the exposure assessment for veterinary medicinal products

Montforts

2006

Science of The Total Environment

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Under the EU Directive 2004/28/EC, an environmental risk assessment of new veterinary medicinal products is required. Given the nature of risk assessment for new applications, there is a need to model exposure concentrations. Critical evaluations are essential to ensure that the use of models by regulators does not result in the propagation of misleading information. The empirical validations of soil exposure models, previously discussed in this journal, indicate that it is impossible to analyse the contribution of every model parameter to the variability in the predictions. In particular, the prediction of the slurry concentration is challenged by uncertainties concerning dilution, mixing and dissipation of residues. Surface water and groundwater models generated highly deviating results compared to the field results, questioning the usefulness of the available screening models. Animal husbandry, slurry handling and environmental conditions throughout Europe are considered in order to define realistic worst case scenarios, to be used in conjunction with distribution models for the environmental risk assessment of veterinary medicinal products at registration. Given the variability in manure management practice throughout Europe, a deterministic approach for the manure-to-soil model was selected. Both worst case and best case scenario were developed. Several modelling assumptions applied in the surface water exposure model for fish nursery effluent were validated against newly available data. Since the available data give no proof that a settling tank contributes to the removal of pesticides from waste water, it is recommended for risk assessment purposes to consider the contribution of the settling tank to removal of pesticides and medicines to be negligible. Surface water dilution factors may be considered to be rather small, a factor of 2, for low flow situations.

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Presence of Macrolide‐Lincosamide‐Streptogramin B and Tetracycline Antimicrobials in Swine Waste Treatment Processes and Amended Soil

Cited by 47 publications

References 20 publications

Fate of antimicrobials and antimicrobial resistance genes in simulated swine manure storage

Fate of antimicrobials and antimicrobial resistance genes in simulated swine manure storage

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Validation of the exposure assessment for veterinary medicinal products

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