Presence of nano-sized chitosan-layered silicate composites protects against toxicity induced by lead ions

Liu, Xinqin; Huang, Rong; Zhou, Xue; Cai, Tongjian; Chen, Jiajia; Shi, Xiaowen; Deng, Hongbing; Luo, Wenjing

doi:10.1016/j.carbpol.2016.11.084

Cited by 5 publications

(1 citation statement)

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“…Of note is that certain gut bacteria ferment the polysaccharides to produce short-chain fatty acids (SCFAs), which maintain the epithelial barrier function and protect against colitis (Zhang et al, 2018). Biocompatible and non-toxic polysaccharide/clay composites are widely used for biomedical applications as drug delivery systems, tissue engineering scaffolds, wound dressings and detoxifying agents (Wu et al, 2019;Liu et al, 2017). However, such composites have practically not been studied on alleviating ailments caused by the administration of nonsteroidal anti-inflammatory drugs (Dragan & Dinu, 2020;Meirelles & Raffin, 2017).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Protective Properties of Pectin/Montmorillonite Composites Against Aspirin-Induced Enterocolitis

Auyezkhanova¹,

Talgatov²,

Akhmetova³

et al. 2020

PTQ

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Long term use of aspirin for prevention of cardiovascular events is limited by its gastrointestinal adverse effects, and, therefore, patients at high risk should receive gastroprotective agents. However, gastroprotective drugs also have a few adverse effects that require searching for safe and effective alternatives. The composites combining the swelling properties of clays and the biological activity of polysaccharides seem to be promising candidates for gastrointestinal protection. This study aimed to characterize pectin/montmorillonite composites and evaluate their protective effect on the gastrointestinal tract of rats taking aspirin over a long period. A series of composites based on montmorillonite (ММТ) and low esterified pectin (Pec) was synthesized using the adsorption-precipitation method. The polysaccharide to clay weight ratios were 1:19, 1:9, and 1:4. The composites were characterized using Thermogravimetric Analysis (TGA), Infrared Spectroscopy (IR), Scanning Electron Microscopy (SEM), and X-Ray Diffraction (XRD). Pectin was completely fixed on MMT, and the polysaccharide content in the composites was approximately 5, 10, and 20 wt%, respectively. The shifting of the absorption band of the C=O group of the pectin indicated the interaction of the polysaccharide with the clay, confirming effective immobilization of Pec on MMT. Modification with pectin changed the morphology and structure of the MMT due to the surface coating and intercalation into the interlayer space. The composites swelled in acidified water (pH = 2.0), and their swelling ability was higher to compare with unmodified MMT. The sorption capacity of Pec/MMT composites towards acetylsalicylic acid (ASA) was decreased from 6.8 to 1.0 mg g-1 with increasing of pectin content from 5 to 20 wt%. The hybrid composites promoted the protection of the gastrointestinal tract of rats, which were administered ASA with Pec/MMTs for 16 days. Protective properties of the Pec/MMT have been improved with increasing pectin content from 5 to 20 wt%.

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