Presence of SNAP-23 and syntaxin 4 in mouse and hamster peritoneal mast cells

Salinas, Eva; Rodríguez, Gonzalo; Quintanar, J. Luis

doi:10.1016/j.acthis.2007.03.004

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Fusion With the Plasma Membrane Snare Proteins1

Expression Of Snares and Snare Complexes In Mast Cells1

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Cited by 2 publications

(2 citation statements)

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“…As for the t-SNAREs, SNAP-23 seems to play a pivotal role in the secretory events in different immune cells. The latter include neutrophils (Martin-Martin et al, 2000), plasma cells (Reales et al, 2005), eosinophils (Logan et al, 2002), platelets (Polgar et al, 2003), and mast cells (Hepp et al, 2005;Salinas et al, 2007;Vaidyanathan et al, 2001). In mast cells and platelets serine phosphorylation of SNAP-23 regulates exocytosis (Hepp et al, 2005;Polgar et al, 2003).…”

Section: Fusion With the Plasma Membrane Snare Proteinsmentioning

confidence: 97%

Protein trafficking in immune cells

2009

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Section: Fusion With the Plasma Membrane Snare Proteinsmentioning

confidence: 97%

Protein trafficking in immune cells

2009

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“…Various investigators have reported the expression of multiple SNAREs in murine and human mast cells [12,13,15,17,[19][20][21][22][24][25][26][27][28][29][30][31]. Composite RT-PCR data identifying SNARE mRNA in murine and human mast cells are presented in Table 1.…”

Section: Expression Of Snares and Snare Complexes In Mast Cellsmentioning

confidence: 99%

SNARE complex‐mediated degranulation in mast cells

Woska

Gillespie

2012

J Cellular Molecular Medi

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Mast cell function and dysregulation is important in the development and progression of allergic and autoimmune disease. Identifying novel proteins involved in mast cell function and disease progression is the first step in the design of new therapeutic strategies. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a family of proteins demonstrated to mediate the transport and fusion of secretory vesicles to the membrane in mast cells, leading to the subsequent release of the vesicle cargo through an exocytotic mechanism. The functional role[s] of specific SNARE family member complexes in mast cell degranulation has not been fully elucidated. Here, we review recent and historical data on the expression, formation and localization of various SNARE proteins and their complexes in murine and human mast cells. We summarize the functional data identifying the key SNARE family members that appear to participate in mast cell degranulation. Furthermore, we discuss the utilization of RNA interference (RNAi) methods to validate SNARE function and the use of siRNA as a therapeutic approach to the treatment of inflammatory disease. These studies provide an overview of the specific SNARE proteins and complexes that serve as novel targets for the development of new therapies to treat allergic and autoimmune disease.

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Presence of SNAP-23 and syntaxin 4 in mouse and hamster peritoneal mast cells

Cited by 2 publications

References 29 publications

Protein trafficking in immune cells

Protein trafficking in immune cells

SNARE complex‐mediated degranulation in mast cells

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