Presence of α and
 a
 Mating Types in Environmental and Clinical Collections of
 Cryptococcus neoformans
 var.
 gattii
 Strains from Australia

Halliday, Catriona; Bui, Tien; Krockenberger, Mark; Malík, Richard; Ellis, David; Carter, D. A.

doi:10.1128/jcm.37.9.2920-2926.1999

Cited by 101 publications

(44 citation statements)

References 30 publications

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“…Amongst C. neoformans isolates, the mating types (MATa or MATa) were determined as previously described (Halliday et al, 1999). In addition, the mating-type allele pattern was determined in nine C. neoformans isolates (Table 2) by a multiplex PCR using four pairs of primers: NCP1 (aD allele), NAD4 (aA allele), STE20D (aD allele), STE20A (aA allele) and amplified as previously described (Esposto et al, 2004).…”

Section: Mating Typementioning

confidence: 99%

Multilocus sequence typing (MLST) and M13 PCR fingerprinting revealed heterogeneity amongstCryptococcusspecies obtained from Italian veterinary isolates

et al. 2014

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Cryptococcosis represents a fungal disease acquired from the environment with animals serving as host sentinels for human exposure. The aim of this study was to investigate the genetic characteristics of Cryptococcus isolates from veterinary sources (cats, dogs and birds) to understand their epidemiology and the genetic variability of the casual isolates. Mating-type PCR in connection with MLST analysis using the ISHAM consensus MLST scheme for the C. neoformans/C. gattii species complex was used to genotype 17 C. neoformans isolates. In the absence of an MLST typing scheme Cryptococcus adeliensis, C. albidus, C. aureus, C. carnescens, C. laurentii, C. magnus and C. uniguttulatus strains were typed using M13 PCR fingerprinting. All C. neoformans isolates were MATα mating type, but hybrids possessed αADa and aADα mating and serotypes. Two C. neoformans molecular types VNI, VNIV and VNIII and VNII/VNIV hybrids were identified. Amongst the 66 non-C. neoformans strains investigated 55 M13 PCR fingerprinting types were identified. The wide variety of MLST types of C. neoformans and the occurrence of αADa and aADα hybrids in our study supports the notion of genetic recombination in the area studied. The heterogeneity of the non-C. neoformans isolates remains open to further investigations and should be taken into consideration when identifying emergent pathogens.

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Section: Mating Typementioning

confidence: 99%

Multilocus sequence typing (MLST) and M13 PCR fingerprinting revealed heterogeneity amongstCryptococcusspecies obtained from Italian veterinary isolates

et al. 2014

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“…Population genetic studies from Australia have revealed broadly clonal populations, but also identified isolated recombining, highly fertile populations (Campbell et al, 2005b;Saul et al, 2008). A skewed population structure was also evident: sampled areas included populations with c. 1 : 1 mating type ratios, a hallmark of recombining populations, but an a mating type bias in others (Halliday et al, 1999). Remarkably, surveys of C. gattii from Colombia have revealed populations predominantly of a isolates (c. 97%) of both clinical and environmental samples (Escandon et al, 2006).…”

Section: Cryptococcus Gattiimentioning

confidence: 99%

Sexual reproduction and dimorphism in the pathogenic basidiomycetes

Morrow¹,

Fraser²

2009

FEMS Yeast Research

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Many fungi in the Basidiomycota have a dimorphic life cycle, where a monokaryotic yeast form alternates with a dikaryotic hyphal form. Most of the dimorphic basidiomycetes are pathogenic on plants, animals or other fungi. In these species, infection of a host appears to be closely linked to both dimorphism and the process of sexual reproduction. Sex in fungi is governed by a specialized region of the genome known as the mating type locus that confers cell-type identity and regulates progression through the sexual cycle. Here we investigate sexual reproduction and lifestyle in emerging human pathogenic yeasts and plant pathogenic smuts of the Basidiomycota and examine the relationship among sex, dimorphism and pathogenesis.

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“…The α MAT of C. gattii and C. neoformans var. grubii predominates within the environment, 16–19 and for C. gattii , it is linked to the rapid dissemination of organisms in the Pacific Northwest outbreak 15,16 …”

Section: Biologymentioning

confidence: 99%

Cryptococcosis: update and emergence ofCryptococcus gattii

Lester¹,

Malík

Bartlett

et al. 2011

Veterinary Clinical Pathol

123

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Cryptococcosis is a fungal disease that occurs throughout the world. Recent reclassification of Cryptococcus species along with a change in the distribution pattern has prompted reevaluation of the organism and the diseases caused by this pathogen. This review highlights the emergence of Cryptococcus gattii as a primary pathogen in North America and summarizes our current understanding of the disease in mammals and birds.

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Presence of α and a Mating Types in Environmental and Clinical Collections of Cryptococcus neoformans var. gattii Strains from Australia

Cited by 101 publications

References 30 publications

Multilocus sequence typing (MLST) and M13 PCR fingerprinting revealed heterogeneity amongstCryptococcusspecies obtained from Italian veterinary isolates

Multilocus sequence typing (MLST) and M13 PCR fingerprinting revealed heterogeneity amongstCryptococcusspecies obtained from Italian veterinary isolates

Sexual reproduction and dimorphism in the pathogenic basidiomycetes

Cryptococcosis: update and emergence ofCryptococcus gattii

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