Presence versus Proximity: The Role of Pendant Amines in the Catalytic Hydrolysis of a Nerve Agent Simulant

“…For example, NH 2 groups added to the BDC linkers of UiO-66 increase the catalytic activity of the MOF for the hydrolysis of warfare agent simulants. 51 , 52 …”

Section: Surface Chemistry Of Mof Metal Oxide Cluster Nodesmentioning

confidence: 99%

The Surface Chemistry of Metal Oxide Clusters: From Metal–Organic Frameworks to Minerals

et al. 2020

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Many metal–organic frameworks (MOFs) incorporate nodes that are small metal oxide clusters. Some of these MOFs are stable at high temperatures, offering good prospects as catalysts—prospects that focus attention on their defect sites and reactivities—all part of a broader subject: the surface chemistry of metal oxide clusters, illustrated here for MOF nodes and for polyoxocations and polyoxoanions. Ligands on MOF defect sites form during synthesis and are central to the understanding and control of MOF reactivity. Reactions of alcohols are illustrative probes of Zr 6 O 8 node defects in UiO-66, characterized by the interconversions of formate, methoxy, hydroxy, and linker carboxylate ligands and by catalysis of alcohol dehydration reactions. We posit that new reactivities of MOF nodes will emerge from incorporation of a wide range of groups on their surfaces and from targeted substitutions of metals within them.

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“…The major products from sarin hydrolysis are iso ‐propyl methylphosphonic acid and hydrogen fluoride (HF). In fact, the hydrolysis of the G‐ and V‐series in the presence of inorganic bases, small‐molecule organic bases, polymeric bases, or metal–organic frameworks into nontoxic products is currently an active area of research …”

Section: Stability Of Nerve Agent Simulantsmentioning

confidence: 99%

Challenges in Fluorescence Detection of Chemical Warfare Agent Vapors Using Solid‐State Films

et al. 2019

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Organophosphorus (OP)‐based nerve agents are extremely toxic and potent acetylcholinesterase inhibitors and recent attacks involving nerve agents highlight the need for fast detection and intervention. Fluorescence‐based detection, where the sensing material undergoes a chemical reaction with the agent causing a measurable change in the luminescence, is one method for sensing and identifying nerve agents. Most studies use the simulants diethylchlorophosphate and di‐iso‐propylfluorophosphate to evaluate the performance of sensors due to their reduced toxicity relative to OP nerve agents. While detection of nerve agent simulants in solution is relatively widely reported, there are fewer reports on vapor detection using solid‐state sensors. Herein, progress in organic semiconductor sensing materials developed for solid‐state detection of OP‐based nerve agent vapors is reviewed. The effect of acid impurities arising from the hydrolysis of simulants and nerve agents on the efficacy and selectivity of the reported sensing materials is also discussed. Indeed, in some cases it is unclear whether it is the simulant that is detected or the acid hydrolysis products. Finally, it is highlighted that while analyte diffusion into the sensing film is critical in the design of fast, responsive sensing systems, it is an area that is currently not well studied.

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Presence versus Proximity: The Role of Pendant Amines in the Catalytic Hydrolysis of a Nerve Agent Simulant

Cited by 45 publications

References 41 publications

A porous, electrically conductive hexa-zirconium(iv) metal–organic framework

A porous, electrically conductive hexa-zirconium(iv) metal–organic framework

The Surface Chemistry of Metal Oxide Clusters: From Metal–Organic Frameworks to Minerals

Challenges in Fluorescence Detection of Chemical Warfare Agent Vapors Using Solid‐State Films

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