The Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) is a major drilling project designed to investigate fault mechanics and the seismogenic behavior of subduction zone plate boundaries. Expedition 319 is the first riser drilling operation within scientific ocean drilling. Operations included riser drilling at Site C0009 in the forearc basin above the plate boundary fault, non-riser drilling at Site C0010 across the shallow part of the megasplay fault system-which may slip during plate boundary earthquakes-and initial drilling at Site C0011 (incoming oceanic plate) for Expedition 322. At Site C0009, new methods were tested, including analysis of drill mud cuttings and gas, and in situ measurements of stress, pore pressure, and permeability. These results, in conjunction with earlier drilling, will provide a) the history of forearc basin development (including links to growth of the megasplay fault system and modern prism), b) the first in situ hydrological measurements of the plate boundary hanging wall, and c) integration of in situ stress measurements (orientation and magnitude) across the forearc and with depth. A vertical seismic profile (VSP) experiment provides improved constraints on the deeper structure of the subduction zone. At Site C0010, logging-while-drilling measurements indicate significant changes in fault zone and hanging wall properties over short (<5 km) along-strike distances, suggesting different burial and/or uplift history. The first borehole observatory instruments were installed at Site C0010 to monitor pressure and temperature within the megasplay fault zone, and methods of deployment of more complex observatory instruments were tested for future operations.