Preserved verb generation in patients with cerebellar atrophy

Richter, Stefanie; Kaiser, Olaf; Hein-Kropp, Christoph; Dimitrova, Albena; Gizewski, Elke R.; Beck, Andreas; Aurich, Volker; Ziegler, Wolfram; Timmann, Dagmar

doi:10.1016/j.neuropsychologia.2004.01.006

Cited by 43 publications

(32 citation statements)

References 45 publications

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“…Recent studies of adults and children with acquired cerebellar damage report that verb generation learning and0or accuracy generally are not affected despite a slower response time (Frank et al, 2007;Helmuth et al, 1997;Richter et al, 2004Richter et al, , 2005. Our study of congenital cerebellar compromise reveals similar results with respect to learning and response time (without covarying for reading response time) but highlights impairments in accuracy and suggests difficulties with error monitoring.…”

Section: Discussionsupporting

confidence: 70%

“…The cerebellum's role in verb generation, however, remains unclear. Some studies of patients with cerebellar damage caused by stroke, tumor, or atrophy report no learning deficits in this task (Helmuth et al, 1997;Richter et al, 2004). Patients with lateral cerebellar lesions also make more errors on antonym generation (Gebhart et al, 2002) and produce fewer responses on phonemic fluency tasks (Leggio et al, 2000) that, in controls, activate the cerebellum (Hubrich-Ungureanu et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Slower response time but intact learning, based on recent studies of motor learning in children with SBM (i.e., Colvin et al, 2003;Dennis et al, 2006b;Edelstein et al, 2004) and studies of verb generation in adults and children with cerebellar lesions (Frank et al, 2007;Helmuth et al, 1997;Richter et al, 2004Richter et al, , 2005.…”

Section: Introductionmentioning

confidence: 99%

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Verb generation in children with spina bifida

Dennis

Jewell

Hetherington

et al. 2008

J. Inter. Neuropsych. Soc.

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We investigated verb generation in children with spina bifida meningomyelocele (SBM; n 5 55) and in typically developing controls (n 5 32). Participants completed 6 blocks (40 trials each) of a task requiring them to produce a semantically related verb in response to a target noun and an additional 40 trials on which they were simply required to read target nouns aloud. After controlling for reading response time, groups did not differ significantly in verb generation response time or learning. Children with SBM produced more non-verb errors than controls and tended to repeat their mistakes over blocks. Verb generation performance was associated with brain volume measures in participants with SBM. Congenital cerebellar dysmorphology is associated with impaired performance in verb generation accuracy, although not with increased response times to produce verbs. (JINS, 2008, 14, 181-191.)

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

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Verb generation in children with spina bifida

Dennis

Jewell

Hetherington

et al. 2008

J. Inter. Neuropsych. Soc.

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“…The phonological similarity effect should be diminished with 5 Interestingly, lexical retrieval paradigms seem to show the same discrepancy between neuroimaging findings that consistently indicate cerebellar involvement and preserved behavioral outcomes (although not necessarily identical cognitive processes) in cerebellar patients (e.g., Helmuth et al, 1997;Richter et al, 2004). damage to the phonological short-term store with either presentation modality, given that it is the proposed locus of the effect.…”

Section: The Present Studymentioning

confidence: 96%

Reduced phonological similarity effects in patients with damage to the cerebellum

et al. 2005

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Ten cerebellar patients were compared to ten control subjects on a verbal working memory task in which the phonological similarity of the words to be remembered and their modality of presentation were manipulated. Cerebellar patients demonstrated a reduction of the phonological similarity effect relative to controls. Further, this reduction did not depend systematically upon the presentation modality. These results first document that qualitative differences in verbal working memory may be observed following cerebellar damage, indicating altered cognitive processing, even though behavioral output as measured by the digit span may be within normal limits. However, the results also present problems for the hypothesis that the cerebellar role is specifically associated with articulatory rehearsal as conceptualized in the Baddeley-Hitch model of working memory. Keywordscerebellum; verbal working memory; speech perception; language; cognition; short-term memory; dysarthria; aphasia Researchers in cognitive neuroscience have in many cases looked to converging data from multiple methodologies when investigating a cognitive process of interest. The complementary perspectives of functional neuroimaging and cognitive neuropsychology are often employed in this regard; a strong case can be made for the involvement of a brain region in a given cognitive process when it is both metabolically active when healthy participants engage in the cognitive process, and when damage to this region disrupts the same cognitive process. Although the precise nature of this involvement may prove elusive to characterize, the brain region comes to be regarded as an essential component of the system in question. When the two methodologies of neuroimaging and neuropsychology do not converge, however, even the most basic question of whether a given region is involved in a cognitive process is difficult to address.One issue that must be kept in mind when making comparisons between data from neuroimaging and data from neuropsychology is that the two methods provide very different kinds of evidence about cognition. Neuroimaging studies have the potential to document qualitative aspects of cognitive processing that may not be evident from the behavioral outcome. In contrast, neuropsychological data -particularly that from standardized batteries that examine for gross impairment across a wide range of cognitive tasks -sometimes do not NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript allow for such an observation. Identical behavioral outcomes may become falsely equated with identical cognitive processes, when this most certainly is not always the case. 1 Neuropsychological studies must be designed such that the relevant qualitative as well as quantitative differences in a cognitive process may be observed.A relative lack of convergence in the neuroimaging and neuropsychological literatures was a part of the motivation for the current study, which investigated the verbal working memory abilities of patients with damage...

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“…As far as verb-generation tasks are concerned, findings are inconsistent. Some studies showed that patients with right-sided cerebellar lesions were unable to reduce their reaction times over blocks of trials and/or produced incorrect answers (Fiez et al 1992;Gebhart et al 2000), whereas no impairments were found in other studies (Helmuth et al 1997;Richter et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Children and Adolescents With Chronic Cerebellar Lesions Show No Clinically Relevant Signs of Aphasia or Neglect

Richter

Schoch²,

Kaiser³

et al. 2005

Journal of Neurophysiology

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. Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect. J Neurophysiol 94: 4108 -4120, 2005. First published July 20, 2005 doi:10.1152/jn.00611.2005. We studied language and visuospatial functions of 12 children and adolescents who had undergone surgery for cerebellar astrocytoma without subsequent radiation or chemotherapy and compared them with 27 age-, gender-, and education-matched healthy control subjects. To study possible lateralization of the functions of the left and right cerebellar hemispheres, subjects performed several language tasks including a verb-generation task as well as standard neglect and extinction tests. Three-dimensional-MR images confirmed that lesions affected cerebellar hemispheres in all children but one who had a pure vermal lesion. The right cerebellar hemisphere was affected in six, the left hemisphere in four children, and both hemispheres in one child. There were no signs of aphasia in the children or adolescents with cerebellar lesions. Language abilities did not differ between cerebellar patients and control subjects except for small increases in reaction times in verb generation in patients with left-sided lesions. Visuospatial functions were also intact in cerebellar subjects except for minor group differences in neglect tasks. In sum, chronic focal cerebellar lesions acquired in childhood or youth do not result in persistent language disorders or clinically significant signs of spatial neglect or extinction.

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Preserved verb generation in patients with cerebellar atrophy

Cited by 43 publications

References 45 publications

Verb generation in children with spina bifida

Verb generation in children with spina bifida

Reduced phonological similarity effects in patients with damage to the cerebellum

Children and Adolescents With Chronic Cerebellar Lesions Show No Clinically Relevant Signs of Aphasia or Neglect

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