Pressure Pulse Wave Velocity and Axial Prestretch in Arteries

Horny, Lukas; Kužma, Ján

doi:10.1007/978-981-10-9038-7_123

Cited by 3 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing axial pretension has been reported to lower circumferential stiffness in elastomeric tubes 64 and this effect would be expected to lower pulse wave velocity. 65 Conversely, effective circumferential stiffening away from the phantom midsection due to end fixation would increase the regional pulse wave velocity. While this aspect of phantom behavior was not examined, as pretension was consistent between designs and effects likely modest, pretension is unlikely to interfere with comparison of compliance 66 and pulse wave velocity 65 between designs or to previously reported pulse wave velocities obtained in 3D printed phantoms.…”

Section: Discussionmentioning

confidence: 99%

“… 65 Conversely, effective circumferential stiffening away from the phantom midsection due to end fixation would increase the regional pulse wave velocity. While this aspect of phantom behavior was not examined, as pretension was consistent between designs and effects likely modest, pretension is unlikely to interfere with comparison of compliance 66 and pulse wave velocity 65 between designs or to previously reported pulse wave velocities obtained in 3D printed phantoms. Temperature effects were not investigated; during pulsatile data collection fluid temperature varied up to 1.7°C within designs and 8.1°C between designs ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A structural approach to 3D-printing arterial phantoms with physiologically comparable mechanical characteristics: Preliminary observations

Guest

Arroyo

Runciman

2022

Proc Inst Mech Eng H

View full text Add to dashboard Cite

Pulse wave behavior is important in cardiovascular pathophysiology and arterial phantoms are valuable for studying arterial function. The ability of phantoms to replicate complex arterial elasticity and anatomy is limited by available materials and techniques. The feasibility of improving phantom performance using functional structure designs producible with practical 3D printing technologies was investigated. A novel corrugated wall approach to separate phantom function from material properties was investigated with a series of designs printed from polyester-polyurethane using a low-cost open-source fused filament fabrication 3D printer. Nonpulsatile pressure-diameter data was collected, and a mock circulatory system was used to observe phantom pulse wave behavior and obtain pulse wave velocities. The measured range of nonpulsatile Peterson elastic strain modulus was 5.6–19 to 12.4–33.0 kPa over pressures of 5–35 mmHg for the most to least compliant designs respectively. Pulse wave velocities of 1.5–5 m s−1 over mean pressures of 7–55 mmHg were observed, comparing favorably to reported in vivo pulmonary artery measurements of 1–4 m s−1 across mammals. Phantoms stiffened with increasing pressure in a manner consistent with arteries, and phantom wall elasticity appeared to vary between designs. Using a functional structure approach, practical low-cost 3D-printed production of simple arterial phantoms with mechanical properties that closely match the pulmonary artery is possible. Further functional structure design development to expand the pressure range and physiologic utility of dir"ectly 3D-printed phantoms appears warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A structural approach to 3D-printing arterial phantoms with physiologically comparable mechanical characteristics: Preliminary observations

Guest

Arroyo

Runciman

2022

Proc Inst Mech Eng H

View full text Add to dashboard Cite

show abstract

“…The fiber distribution and stiffening effect will affect the PWV in the artery. Few existing studies have investigated the impact of material non-linearity and anisotropy on the PWV [12,13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Nonlinear Hyperelastic Property of Arterial Tissues on the Pulse Wave Velocity Based on the Unified-Fiber-Distribution (UFD) Model

et al. 2023

View full text Add to dashboard Cite

Pulse wave velocity (PWV) is a key, independent risk factor for future cardiovascular events.The Moens-Korteweg equation describes the relation between PWV and the stiffness of arterial tissue with an assumption of isotopic linear elastic property of the arterial wall. However, the arterial tissue exhibits highly nonlinear and anisotropic mechanical behaviors. There is a limited study regarding the effect of arterial nonlinear and anisotropic properties on the PWV. In this study, we investigated the impact of the arterial nonlinear hyperelastic properties on the PWV, based on our recently developed unified-fiber-distribution (UFD) model. The UFD model considers the fibers (embedded in the matrix of the tissue) as a unified distribution, which expects to be more physically consistent with the real fiber distribution than existing models that separate the fiber distribution into two/several fiber families. With the UFD model, we fitted the measured relation between the PWV and blood pressure which obtained a good accuracy. We also modeled the aging effect on the PWV based on observations that the stiffening of arterial tissue increases with aging, and the results agree well with experimental data. In addition, we did parameter studies on the dependence of the PWV on the arterial properties of fiber initial stiffness, fiber distribution, and matrix stiffness. The results indicate the PWV increases with increasing overall fiber component in the circumferential direction. The dependences of the PWV on the fiber initial stiffness, and matrix stiffness are not monotonic and change with different blood pressure. The results of this study could provide new insights into arterial property changes and disease information from the clinical measured PWV data.

show abstract

Effect of Nonlinear Hyperelastic Property of Arterial Tissues on the Pulse Wave Velocity based on the Unified-Fiber-Distribution (UFD) Model

Dong

Liu

Woodall

et al. 2022

Preprint

View full text Add to dashboard Cite

Pulse wave velocity (PWV) is a key, independent risk factor for future cardiovascular events. The Moens-Korteweg equation describes the relation between PWV and the stiffness of arterial tissue with an assumption of isotopic linear elastic property of the arterial wall. However, the arterial tissue exhibits highly nonlinear and anisotropic mechanical behaviors. There is a limited study regarding the effect of arterial nonlinear and anisotropic properties on the PWV. In this study, we investigated the impact of the arterial nonlinear hyperelastic properties on the PWV, based on our recently developed unified-fiber-distribution (UFD) model. The UFD model considers the fibers (embedded in the matrix of the tissue) as a unified distribution, which expects to be more physically consistent with the real fiber distribution than existing models that separate the fiber distribution into two/several fiber families. With the UFD model, we fitted the measured relation between the PWV and blood pressure which obtained a good accuracy. We also modeled the aging effect on the PWV based on observations that the stiffening of arterial tissue increases with aging, and the results agree well with experimental data. In addition, we did parameter studies on the dependence of the PWV on the arterial properties of fiber initial stiffness, fiber distribution, and matrix stiffness. The results indicate the PWV increases with increasing overall fiber component in the circumferential direction. The dependences of the PWV on the fiber initial stiffness, and matrix stiffness are not monotonic and change with different blood pressure. The results of this study could provide new insights into arterial property changes and disease information from the clinical measured PWV data.

show abstract

Pressure Pulse Wave Velocity and Axial Prestretch in Arteries

Cited by 3 publications

References 15 publications

A structural approach to 3D-printing arterial phantoms with physiologically comparable mechanical characteristics: Preliminary observations

A structural approach to 3D-printing arterial phantoms with physiologically comparable mechanical characteristics: Preliminary observations

Effect of Nonlinear Hyperelastic Property of Arterial Tissues on the Pulse Wave Velocity Based on the Unified-Fiber-Distribution (UFD) Model

Effect of Nonlinear Hyperelastic Property of Arterial Tissues on the Pulse Wave Velocity based on the Unified-Fiber-Distribution (UFD) Model

Contact Info

Product

Resources

About