Preterm Infants With Congenital Heart Disease and Bronchopulmonary Dysplasia: Postoperative Course and Outcome After Cardiac Surgery

McMahon, Colin J.; Penny, Daniel J.; Nelson, David P.; Ades, Anne; Maskary, Salim Al; Speer, Michael E.; Katkin, Julie P.; McKenzie, E. Dean; Fraser, Charles D.; Chang, Anthony

doi:10.1542/peds.2004-2168

Cited by 39 publications

(29 citation statements)

References 41 publications

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“…396 Infants with an ASD or a VSD with concomitant chronic lung disease are at an increased risk for the early development of severe PVD and complications after cardiac surgery. 397 The presence of resting cyanosis (oxygen saturation <90%) is worrisome because it predicts risk of elevated PVR and death after closure of the defect. 395 In the EuroHeart survey of adults with CHD, hemodynamics at follow-up were worse in nonoperated patients with ASD than in the patients whose defects had been closed, especially those with moderate or large defects.…”

Section: Pah With Systemic-to-pulmonary Shuntmentioning

confidence: 99%

Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

948

405

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Abstract-Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patients with pulmonary hypertension have been limited by the lack of consensus guidelines from experts in the field. In a joint effort from the American Heart Association and American Thoracic Society, a panel of experienced clinicians and clinician-scientists was assembled to review the current literature and to make recommendations on the diagnosis, evaluation, and treatment of pediatric pulmonary hypertension. This publication presents the results of extensive literature reviews, discussions, and formal scoring of recommendations for the care of children with pulmonary hypertension. Key Words: AHA Scientific Statements ◼ bronchopulmonary dysplasia ◼ congenital diaphragmatic hernia ◼ congenital heart disease ◼ genetics ◼ persistent pulmonary hypertension of the newborn ◼ sickle cell disease © 2015 by the American Heart Association, Inc., and the American Thoracic Society.Circulation is available at http://circ.ahajournals.org DOI: 10.1161/CIR.0000000000000329 †Deceased. The American Heart Association and the American Thoracic Society make every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This document was approved by the American Heart Association Science Advisory and Coordinating Committee on May 12, 2015, the American Heart Association Executive Committee on July 22, 2015, and the American Thoracic Society on July 24, 2015.The online-only Data Supplement is available with this article at http://circ.ahajournals.org/lookup/suppl/doi:10.1161/CIR.0000000000000329/-/DC1. The American Heart Association requests that this document be cited as follows: Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; on behalf of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, Council on Clinical Cardiology, Council on Cardiovascular Disease in the Young, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Surgery and Anesthesia, and the American Thoracic Society. Pediatric pulmonary hypertension: guidelines from the American Heart Association and American Thoracic Society. Circulation. 2015;132:2037-2099 Copies: This document is available on the World Wide Web site of the American Heart Associat...

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Section: Pah With Systemic-to-pulmonary Shuntmentioning

confidence: 99%

Pediatric Pulmonary Hypertension

Abman¹,

Hansmann²,

Archer³

et al. 2015

Circulation

948

405

View full text Add to dashboard Cite

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“…Higher operative mortality rates were also reported for preterm infants undergoing open surgical procedures for congenital heart defects compared with term infants [36]. Bronchopulmonary dysplasia (BPD) occurs almost exclusively in very preterm infants, and infants with BPD who underwent surgery for congenital heart disease had significantly higher rates of postoperative complications and mortality compared with age and lesionmatched controls [37]. With continual innovations in high-risk obstetrical and neonatal care and the concomitant improving survival of very preterm infants, the number of infants with major congenital malformations who also experience the serious complications associated with prematurity will likely increase in the future.…”

Section: Discussionmentioning

confidence: 98%

The Association Between Major Birth Defects and Preterm Birth

Honein¹,

Kirby

Meyer

et al. 2008

Matern Child Health J

114

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Objective To evaluate the association between preterm birth and major birth defects by maternal and infant characteristics and specific types of birth defects. Study Design We pooled data for 1995-2000 from 13 states with population-based birth defects surveillance systems, representing about 30% of all U.S. births. Analyses were limited to singleton, live births from 24-44 weeks gestational age. Results Overall, birth defects were more than twice as common among preterm births (24-36 weeks) compared with term births (37-41 weeks gestation) (prevalence ratio [PR] = 2.65, 95% confidence interval [CI] 2.62-2.68), and approximately 8% of preterm births had a birth defect. Birth defects were over five times more likely among very preterm births (24-31 weeks gestation) compared with term births (PR = 5.25, 95% CI 5.15-5.35), with about 16% of very preterm births having a birth defect. Defects most strongly associated with very preterm birth included central nervous system defects (PR = 16.23, 95% CI 15.49-17.00) and cardiovascular defects (PR = 9.29, 95% CI 9.03-9.56). Conclusions Birth defects contribute to the occurrence of preterm birth. Research to identify shared causal pathways and risk factors could suggest appropriate interventions to reduce both preterm birth and birth defects.

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“…In one study of infants with bronchopulmonary dysplasia (BPD) who underwent cardiac surgery for repair of CHD, it was shown that 25% of those who died had PAH. [24] Patients with cyanotic CHD, such as transposition of the great arteries, truncus arteriosus, and single ventricle with unrestricted pulmonary flow may also develop PAH. Palliative shunt operations for certain cardiac anomalies designed to increase pulmonary flow may also lead to subsequent development of PAH.…”

Section: Selected Clinical Groups Of Pulmonary Hypertension In Childrenmentioning

confidence: 99%

“…Various developmental lung anomalies are recognized as the etiology of PH, such as surfactant protein deficiencies, lung hypoplasia, congenital diaphragmatic hernia, alveolar capillary dysplasia, pulmonary alveolar proteinosis, pulmonary interstitial glycogenosis, and pulmonary lymphangiosis. [2428] Recent studies on BPD patients have suggested that abnormalities of the pulmonary vasculature may be a primary rather than secondary cause of abnormal or decreased alveolarization. In addition to high vascular tone barotraumas altered abnormal smooth muscle proliferation has been recognized as a contributing factor in the development of PVD in BPD.…”

Section: Pulmonary Hypertension Due To Respiratory Diseasesmentioning

confidence: 99%

Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary hypertension in children

et al. 2014

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Pulmonary hypertension (PH) is relatively uncommon in children. Pulmonary arterial hypertension (PAH) in pediatric comprises a wide spectrum of diseases, from a transient neonatal condition to a progressive disease associated with morbidity and mortality. Most common PAH in pediatric are idiopathic (IPAH) or PAH associated with congenital heart disease (PAH-CHD), while other associated conditions, such as connective tissue disease (CTD), are less common in pediatrics. Despite better understanding of PH and the availability of new medications during recent decades; the diagnosis, investigation and choice of therapy remain a challenge in children, as evidence-based recommendations depend mainly on adult studies.In this review, we provide a detailed discussion about the distinctive features of PAH in pediatric, mainly emphacysing on classification and diagnostic algorithm.

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Preterm Infants With Congenital Heart Disease and Bronchopulmonary Dysplasia: Postoperative Course and Outcome After Cardiac Surgery

Cited by 39 publications

References 41 publications

Pediatric Pulmonary Hypertension

Pediatric Pulmonary Hypertension

The Association Between Major Birth Defects and Preterm Birth

Saudi Guidelines on the Diagnosis and Treatment of Pulmonary Hypertension: Pulmonary hypertension in children

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