Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as a Stage Determination in Breast Cancer

Abstract

BACKGROUND: Breast cancer tends to respond differently to treatments, which are usually determined by clinicopathological characteristics. Several studies evaluated the role of the peripheral blood test as diagnostic and prognostic markers in several types of solid cancer and neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) are two of them which already tested. However, the evidence in breast cancer is still lacking. 
 AIM: Therefore, the study aimed to investigate the value of NLR and PLR as biomarkers concerning breast cancer stage.
 METHODS: A retrospective study was conducted using breast cancer patients’ medical records from 2014 to 2019 at Sanglah General Hospital. The histopathological records and complete blood counts of the patients were collected and analyzed risk analysis model, receiver operator characteristics analysis, and correlation of NLR and PLR with cancer staging analysis used correlation test.
 RESULT: One hundred five patients data were used in this study, with 35 subjects had early-stage breast cancer while 70 subjects had an advanced stage. Breast cancer staging with NLR and PLR showed significant associations (p < 0.001). Both NLR and PLR had area under the curve >0.7 (p < 0.001). The cutoff, sensitivity, and specificity values of NLR and PLR were 2.504 (71%; 70%) and 157.1 (73%; 70%). Advanced stage of breast cancer was mostly found in high NLR and PLR value with (OR: 4.231; CI = 1.791-9.995, p < 0.001) and (OR: 3.949; 95% CI = 1.679–9.287; p < 0.001).
 CONCLUSION: From this preliminary study, pretreatment NLR and PLR values might determine the breast cancer stage. Further research is needed to evaluate the association between grade and patient survival.

Effects of Tripterygium wilfordii extracts on the hematological parameters of solid Ehrlich carcinoma bearing mice

“…It has been recently established that some values of CBC like NLR, MLR and PLR are associated with the activity, illness and mortality of various inflammatory diseases and cancer in particular [19]. Obviously, hematological parameters possess numerous advantages owing to the fact that they are reasonable and valid, so they can aid oncologists in growing countries in forecasting cancer progression [20].…”

Hubungan Lymph Vessel Density (LVD) dengan invasi limfatik dan metastasis kelenjar getah bening regional pada karsinoma payudara invasif tipe tidak spesifik di RSUP Sanglah, Bali, Indonesia

“…1-3 Pada karsinoma payudara, penyebaran preferensial melalui pembuluh limfatik berasal dari frekuensi invasi limfatik (Lymph Vessel Invasion atau LVI) lebih tinggi dibandingkan dengan invasi pembuluh darah (Blood Vessel Invasion atau BVI). [1][2][3] Perkembangan metastasis limfatik diduga melibatkan proliferasi pembuluh limfatik (limfangiogenesis), invasi limfatik, dan metastasis kelenjar getah bening secara bertahap. Namun, kemungkinan hubungan lymph vessel density (LVD), invasi limfatik (Lymph Vessel Invasion atau LVI), dan metastasis kelenjar getah bening masih belum jelas.…”

“…3 Status kelenjar getah bening digunakan untuk mengidentifikasi prognosis pasien, stadium tumor dan modalitas terapi. 1,6 Metastasis kelenjar getah bening dianggap sebagai faktor prognostik yang paling penting pada kanker payudara. 7 Beberapa penelitian menunjukkan hasil bahwa LVD berhubungan dengan LVI dan metastasis kelenjar getah bening.…”

“…Status kelenjar getah bening digunakan untuk mengidentifikasi prognosis pasien, stadium tumor dan modalitas terapi. 1,6 Pasien dengan metastasis kelenjar getah bening regional memiliki resiko enam kali lebih tinggi untuk bermetastasis jauh dibandingkan dengan tanpa metastasis kelenjar getah bening regional. 19 Metastasis kelenjar getah bening dianggap sebagai faktor prognostik yang paling penting pada kanker payudara.…”

Correlation of Neutrophil to Lymphocyte Ratio with Interleukin-10 in Diagnosis and Monitoring of Coronavirus Disease-19 Patients

“…A decrease in the number of lymphocytes is associated with disease progression, so it is estimated that the number of lymphocytes can be used as a potential predictor. NLR has been widely used as a marker of the severity of the bacterial infection and to determine the prognosis of patients with pneumonia, tumors, and other malignancy [4], [5]. An increase in NLR indicates a poor clinical prognosis.…”