Pretreatment neutrophil-to-lymphocyte ratio predicts the benefit of gastric cancer patients with systemic therapy

Du, Songtao; Fang, Zhenhao; Lin, Ye; Sun, Huiyan; Deng, Guangtong; Wu, Wei; Zeng, Furong

doi:10.18632/aging.203256

Cited by 20 publications

(9 citation statements)

References 65 publications

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“…The advantage of CXI over Fearon’s criteria is that it includes NLR and serum albumin. Furthermore, previous studies demonstrated that NLR and serum albumin had significant associations with the prognosis in patients with GC [ 32 , 33 , 34 ], which might account for why low CXI, instead of cachexia diagnosed by Fearon’s criteria, was significantly associated with worse OS in this study.…”

Section: Discussionmentioning

confidence: 54%

Cachexia Index as a Prognostic Indicator in Patients with Gastric Cancer: A Retrospective Study

Gong

Wan

Zhao

et al. 2022

Cancers

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The current diagnostic criteria for cancer cachexia are inconsistent, and the prognostic value of cachexia in gastric cancer (GC) is controversial. This study aimed to investigate the prognostic value of the cachexia index (CXI) in patients with GC. We calculated the CXI as skeletal muscle index (SMI) × serum albumin/neutrophil-lymphocyte ratio (NLR), and a total of 161 and 163 patients were included in the high and low CXI groups, respectively. Low CXI was significantly associated with a more advanced tumor–node–metastasis (TNM) stage, a higher level of serum C-reactive protein, serum interleukin-6, and NLR, but also a decreased level of serum prealbumin and albumin. In addition, patients in the low CXI group were more likely to have postoperative pulmonary infections (9.8% vs. 3.7%, p = 0.03). Cox proportional analyses indicated that patients with low CXI (HR 0.45, 95% CI 0.29 to 0.69; p < 0.001) or TNM stage III+IV (HR 4.38, 95% CI 2.54 to 7.55; p < 0.001) had a significantly poorer overall survival (OS). Kaplan–Meier survival curves suggested that patients with low CXI had a significantly decreased OS, which was not affected by subgroup analyses of different sex, age, cachexia, body mass index (BMI), and TNM stage. Furthermore, low CXI combined with cachexia, low BMI, or TNM stage III+IV caused the worst OS in each subgroup analysis, respectively. Our study demonstrated that CXI had a good prognostic value in GC. Greater attention should be paid to patients with low CXI, particularly those combined with cachexia, low BMI, or TNM stage III+IV.

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Section: Discussionmentioning

confidence: 54%

Cachexia Index as a Prognostic Indicator in Patients with Gastric Cancer: A Retrospective Study

Gong

Wan

Zhao

et al. 2022

Cancers

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“…The neutrophils, lymphocytes, platelets, monocytes and C-reactive protein are all common inflammatory biomarkers and a great number of studies have revealed the prognostic role of NLR, PLR, LMR and GPS in tumors. Several met-analyses demonstrated that elevated pretreatment NLR was a prognostic risk factor in colorectal cancer (HR = 1.57, 95%CI: 1.39-1.78, P < 0.001)[ 36 ], gastric cancer (HR = 1.78, 95%CI: 1.59-1.99, P < 0.001)[ 37 ], laryngeal cancer (HR = 1.76, 95%CI: 1.53-2.03, P < 0.001)[ 38 ] and non-small cell lung cancer patients (HR = 2.86, 95%CI: 2.11-3.87, P < 0.001)[ 39 ]. Furthermore, the prognostic value of GPS has been verified in ovarian cancer (HR = 1.62, 95%CI: 1.38-1.91, P < 0.001), esophageal squamous cell cancer (HR = 1.66, 95%CI: 1.14-2.41, P = 0.008), colorectal cancer (HR = 2.20, 95%CI: 1.88-2.57, P < 0.001) and lung cancer patients (HR = 2.058, 95%CI: 1.51-2.80, P < 0.05) by several meta-analyses[ 14 , 40 - 42 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte ratios and Glasgow prognostic score in osteosarcoma: A meta-analysis

Peng¹,

Li²,

Li³

2022

WJCC

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BACKGROUND Some studies investigated the prognostic role of several blood biomarkers, including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR) and Glasgow prognostic score (GPS), in osteosarcoma, but their results were inconsistent with each other. AIM To identify the prognostic value of NLR, PLR, LMR and GPS in osteosarcoma patients through reviewing relevant studies. METHODS The PubMed, EMBASE, Web of Science and CNKI databases were searched up to October 2, 2021. The primary and second outcomes were overall survival (OS) and disease-free survival (DFS), respectively. The hazard ratios (HRs) with 95% confidence intervals (CIs) were combined to assess the association between these indicators and prognosis of osteosarcoma patients. RESULTS A total of 13 studies involving 2087 patients were eventually included. The pooled results demonstrated that higher NLR and GPS were significantly associated with poorer OS (HR = 1.88, 95%CI: 1.38-2.55, P < 0.001; HR = 2.19, 95%CI: 1.64-2.94, P < 0.001) and DFS (HR = 1.67, 95%CI: 1.37-2.04, P < 0.001; HR = 2.50, 95%CI: 1.39-4.48, P < 0.001). However, no significant relationship of PLR and LMR and OS ( P = 0.085; P = 0.338) and DFS ( P = 0.396; P = 0.124) was observed. CONCLUSION Higher NLR and GPS were related with worse prognosis and might serve as novel prognostic indicators for osteosarcoma patients.

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“…Low ALC and high AMC have been reported as prognostic factors for OS and disease-free survival (DFS) in resectable stomach cancer, with cutoff values of 1734/µL and 1720/µL, and 672.4/µL and 510/µL, respectively [ 17 , 18 ]. The prognostic significance of NLR, LMR, and PLR in stomach cancer has been reported in several meta-analyses ( Table 6 ) [ 13 , 19 , 20 , 21 , 22 ]. Although the target population and cutoff values of each study were widely heterogeneous, an increase in NLR and PLR and a decrease in LMR were associated with a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Preoperative Hematological Parameters in Patients with D2-Resected, Node-Positive Stomach Cancer

Park

Lim

et al. 2022

Biomedicines

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The purpose of the present study was to investigate the clinical significance of preoperative hematological parameters in patients with advanced stomach cancer, and to explore who might benefit from adjuvant concurrent chemoradiotherapy (CCRT) compared to chemotherapy alone. Among 1032 patients with node-positive stomach cancer who had a confirmed diagnosis after complete D2 resection, and who received adjuvant chemotherapy alone or CCRT, a total of 692 patients was selected using propensity score matching. Among absolute neutrophil count, absolute lymphocyte count (ALC), absolute monocyte count (AMC), platelet count, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and platelet-to-lymphocyte ratio, AMC was the most relevant prognostic factor for overall survival and recurrence-free survival (hazard ratio (HR) 1.674, 95% confidence interval (CI) 1.180–2.376; HR 1.908, 95% CI 1.650–2.695, respectively). In a subgroup with a high ALC, patients treated with adjuvant CCRT had a favorable recurrence-free survival (HR 0.620, 95% CI 0.393–0.980) compared to those treated with chemotherapy alone. Further study is needed to confirm our findings and to develop tailored adjuvant treatment.

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Pretreatment neutrophil-to-lymphocyte ratio predicts the benefit of gastric cancer patients with systemic therapy

Cited by 20 publications

References 65 publications

Cachexia Index as a Prognostic Indicator in Patients with Gastric Cancer: A Retrospective Study

Cachexia Index as a Prognostic Indicator in Patients with Gastric Cancer: A Retrospective Study

Prognostic value of neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte ratios and Glasgow prognostic score in osteosarcoma: A meta-analysis

Clinical Significance of Preoperative Hematological Parameters in Patients with D2-Resected, Node-Positive Stomach Cancer

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