Pretreatment with lipopolysaccharide amelioratesPseudomonasexotoxin A-induced hepatotoxicity in rats

Abstract

These results suggested that Kupffer cells, TNF-α and TLR-4 play central mediator roles during the hepatoprotection against PEA-induced hepatotoxicity conferred by LPS.

Differences in Genetic Background Contribute to Pseudomonas Exotoxin A-Induced Hepatotoxicity in Rats

“…In contrast, PEA treatment induced only low numbers of apoptotic and necrotic hepatocytes in both Wistar and F344 rats. These differences in hepatotoxicity are observed not only with a sub-lethal dose of PEA as shown herein, but also with other mechanistically different models of T-cell-dependent liver injury after treatment with Concanavalin A, acetaminophen or lipopolysaccharide (LPS) treatment [ 10 , 11 , 16 , 17 ]. Importantly, these results can serve as reference data relating to PEA treatment in different rat genetic backgrounds, which may prove useful for PEA-based anti-tumor drug development.…”

Chrysin Effect in Prevention of Acetaminophen-Induced Hepatotoxicity in Rat

“…According to a study, after oral administration of different doses of chrysin, inflammation and fibrosis in chronic renal disease decreased in wistar rats in a dose-dependent manner. Hepatic markers also decreased and did not affect IL-1β, but effectively reduced the levels of TNF-α . Moreover, due to the simultaneous increase of TNF-α and IL-2 levels in hepatotoxicity cases and the reduction of IL-2 concentration after treatment, and according to a study about the treatment of hepatotoxicity with lipopolysaccharide, the concentrations of TNF-α and IL-2 decreased, while serum levels of IL-6 and IL-10 increased after treatment .…”

“…Hepatic markers also decreased and did not affect IL-1β, but effectively reduced the levels of TNF-α. 13 Moreover, due to the simultaneous increase of TNF-α and IL-2 levels in hepatotoxicity cases and the reduction of IL-2 concentration after treatment, and according to a study about the treatment of hepatotoxicity with lipopolysaccharide, the concentrations of TNF-α and IL-2 decreased, while serum levels of IL-6 and IL-10 increased after treatment. 14 According to a report by Rehman MU about cisplatin hepatotoxicity, chrysin can confront oxidative stress and inflammation and can have an effective role in reducing this side effect.…”

“…The flavonoid chrysin (5,7-dihydroxyflavone) is extracted from some plants and propolis . Several reports have shown that chrysin has antioxidant, anti-inflammatory, , and radical scavenging effects, and reduces the inflammation and fibrosis of chronic kidney disease, hepatic markers, and TNF-α in rats . Chrysin regulates blood glucose level by activating insulin signaling in the gastrocnemius muscle in cases of obesity and type II diabetes, and has inhibitory effects on the proliferation of gastric cancer cells. , This compound plays a positive role in the reproductive system of rats, and can regulate serum testosterone levels and reduce the unhealthy sperm by increasing sperm motility and accumulation and can be effective in male infertility treatment .…”

“…11 The flavonoid chrysin (5,7-dihydroxyflavone) is extracted from some plants and propolis. 12 Several reports have shown that chrysin has antioxidant, anti-inflammatory, 13,14 and radical scavenging 15 effects, and reduces the inflammation and fibrosis of chronic kidney disease, hepatic markers, and TNF-α in rats. 13 Chrysin regulates blood glucose level by activating insulin signaling in the gastrocnemius muscle in cases of obesity and type II diabetes, 16 and has inhibitory effects on the proliferation of gastric cancer cells.…”