2018
DOI: 10.21608/ajfm.2018.18076
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Pretreatment with the Micro-alga, Spirulina Platensis Ameliorates Cyclophosphamide -Induced Hematological, Liver and Kidney Toxicities in Male Mice.

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Cited by 8 publications
(8 citation statements)
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“…Our findings agree with an earlier article that reported a similar effect of CP on oxidative stress and related bone marrow toxicity [7,8,12]. When we administered CP 200, we also found significant reductions in RBC, WBC, granulocyte, lymphocyte, monocyte, and platelet counts and Hb levels, in agreement with earlier findings [1,[6][7][8][9][10][14][15][16]42]. Treatment with NER 400 reduced the level of MDA, increased the levels of CAT, SOD, granulocytes, lymphocytes, and monocytes, and reversed myelotoxic and hematological manifestations.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Our findings agree with an earlier article that reported a similar effect of CP on oxidative stress and related bone marrow toxicity [7,8,12]. When we administered CP 200, we also found significant reductions in RBC, WBC, granulocyte, lymphocyte, monocyte, and platelet counts and Hb levels, in agreement with earlier findings [1,[6][7][8][9][10][14][15][16]42]. Treatment with NER 400 reduced the level of MDA, increased the levels of CAT, SOD, granulocytes, lymphocytes, and monocytes, and reversed myelotoxic and hematological manifestations.…”
Section: Discussionsupporting
confidence: 93%
“…PM is an anticancer metabolite, whereas acrolein is a toxic metabolite, responsible for hematological toxicity and myelotoxicity [5]. CP or its metabolite reacts with glutathione (GSH), restricts its antioxidant activity, increases the production of reactive oxygen species, and causes lipid peroxidation that leads to oxidative stress [3,6,7]. CP has also been reported to induce the production of inflammatory cytokines such as tumor necrosis factor (TNF)-a, interleukin (IL)-6, and IL-1b [8].…”
mentioning
confidence: 99%
“…The post‐mitochondrial fractions of the testes and epididymis were obtained by the centrifugation of homogenates at 12,000 g for 15 min at 4°C. Catalase (CAT), thiobarbituric acid reactive substances (TBARS) and nitrate levels were determined according to a previously published method (El‐Naggar, Ibrahim, El‐Tantawi, & Al‐Sharkawi, ). TNF‐α was estimated by using ELISA kits, and procedures were followed according to the instruction of the manufacturer.…”
Section: Methodsmentioning
confidence: 99%
“…Most medicinal were investigated to exert their antitumor effect or screen their effect to ameliorate the toxic effects of the chemotherapy [5] For instance, the antitumor efficacy of Rosmarinus officinalis, Spirulina platensis, Nigella sativa, and scorpion venom were evaluated as anticancer agents [6].…”
Section: Introductionmentioning
confidence: 99%