Prevalence and Associated Features of Albuminuria in Koreans with NIDDM

Lee, Ki‐Up; Park, Joong Y.; Kim, Sang W; Lee, Mee H; Kim, Ghi S; Park, Su-Kil; Park, Jungsik

doi:10.2337/diacare.18.6.793

Cited by 38 publications

(27 citation statements)

References 25 publications

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“…85 The relationship between microalbuminuria (albuminuria) and clinical CVD has been confirmed in diverse racial/ethnic groups, including Koreans, American Indians, and Asian Indians. 81,86,87 Although the relationship is present in both type 1 and type 2 diabetes, the relationship is generally stronger in type 2 diabetes because of the older age of individuals with this disease. Framingham women 5209 CVD mortality Ϫ Ϫ ϩ indicates that the author concluded that proteinuria was an independent risk factor for the outcome after adjustment for all other risk factors; Ϫ, the author concluded that proteinuria was not an independent risk factor for the outcome after adjustment for all other risk factors.…”

Section: Cvd In Diabetic Kidney Diseasementioning

confidence: 99%

“…Diabetic subjects with microalbuminuria also have an increased prevalence of dyslipidemia, poor glucose control, and increased blood pressure compared with diabetic patients without microalbuminuria. 80,81 There is a strong association between microalbuminuria (albuminuria) and CVD in cross-sectional analysis. This relationship has been found for surrogate measures, such as carotid intima-media thickness 82 and LVH, 83,84 and different clinical presentations of CVD, such as coronary artery disease 81,84 and peripheral vascular disease.…”

Section: Cvd In Diabetic Kidney Diseasementioning

confidence: 99%

“…80,81 There is a strong association between microalbuminuria (albuminuria) and CVD in cross-sectional analysis. This relationship has been found for surrogate measures, such as carotid intima-media thickness 82 and LVH, 83,84 and different clinical presentations of CVD, such as coronary artery disease 81,84 and peripheral vascular disease. 85 The relationship between microalbuminuria (albuminuria) and clinical CVD has been confirmed in diverse racial/ethnic groups, including Koreans, American Indians, and Asian Indians.…”

Section: Cvd In Diabetic Kidney Diseasementioning

confidence: 99%

See 2 more Smart Citations

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Sarnak¹,

Levey²,

Schoolwerth³

et al. 2003

Circulation

3,061

752

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Section: Cvd In Diabetic Kidney Diseasementioning

confidence: 99%

Section: Cvd In Diabetic Kidney Diseasementioning

confidence: 99%

Section: Cvd In Diabetic Kidney Diseasementioning

confidence: 99%

See 1 more Smart Citation

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Sarnak¹,

Levey²,

Schoolwerth³

et al. 2003

Circulation

3,061

752

View full text Add to dashboard Cite

“…The frequency of microalbuminuria in our group was 45.5%, with a tendency for increased systolic blood pressure, duration of the diabetes and hypertension In the stepwise multiple regression analysis, systolic blood pressure was the only variable that significantly influenced the rate of UAE. We did not observe a relation between HbA1c and microalbuminuria, sometimes reported 24,25 or not 26,27 in the literature. Possibly, transverse cohort studies, such as ours, are less likely to reveal the influence of glycemic control on the development of microalbuminuria.…”

Section: Arq Bras Cardiol Volume 73 (Nº 1) 1999mentioning

confidence: 66%

“…Although we cannot exclude a type 2 error, due to the size of the sample, other reports in the literature stress that CAD is associated mainly with macroalbuminuria and not microalbuminuria [24][25][26]33,35 . Possibly, this divergence with the literature, excluding data inherent to the studied population, is due to different methods and criteria for coronary disease and microalbuminuria diagnoses.…”

Section: Arq Bras Cardiol Volume 73 (Nº 1) 1999mentioning

confidence: 99%

Coronary artery disease, microalbuminuria and lipid profile in patients with non-insulin dependent diabetes mellitus

Bahia¹,

Gomes²,

Cruz³

et al. 1999

Arq. Bras. Cardiol.

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Diabetes mellitus is an important factor associated with increased cardiovascular morbidity and mortality, due to coronary artery disease (CAD), stroke and peripheral vascular disease. Age adjusted coronary artery disease prevalence in diabetic patients, in the United States, is between 30 and 51%; peripheral vascular disease and stroke prevalences are 9 and 10%, respectively 1 . Recently, a study in Brazil reported a 2.3 greater in-hospital mortality rate in diabetic compared with nondiabetic patients, and the main cause of death was cardiovascular disease 2 .Today, it is recognized that the presence of microalbuminuria, in addition to being a marker of incipient renal disease in diabetic patients, seems to be also a marker of large vessel disease, and is associated with an increased cardiovascular disease mortality, especially coronary heart disease 3-5 . This increased mortality is due, in part, to a greater prevalence of other risk factors in patients with microalbuminuria, such as lipid disorders, hypertension (H), increased fibrinogen levels and blood rheology changes 6,7 . Recent studies from the World Health Organization demonstrated that the presence of proteinuria, in type 2 diabetic patients (DM2), increased the risk of cardiovascular death 3 to 4 times, independent of other risk factors 8 .The presence of microalbuminuria possibly reflects the process of generalized vascular damage, affecting simultaneously glomeruli, the retina and the intimal layer of large vessels. This has been demonstrated by studies of markers of endothelial dysfunction and measurements of transcapillary protein leakage 9,10 .Some studies suggested a common genetic predisposition for microalbuminuria and the early atherosclerotic process in diabetic patients 11 . Others suggested that glomerular mesangeal cells and arterial smooth muscle cells, being both of mesenchimal origin, would suffer the same changes in response to the different metabolic abnormalities observed in these patients, such as functional extracellular matrix changes with the consequent mesangial and medial proliferation, endothelial dysfunction and protein leakage 9 .The present study aimed to analyze the association between coronary artery disease, incipient diabetic renal

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Association of C-reactive protein and hyperuricemia with diabetic nephropathy in Chinese type 2 diabetic patients

Wang

et al. 2008

Acta Diabetol

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To investigate the relationship of micro-albuminuria with C-reactive protein (CRP) and hyperuricemia in Chinese patients with type 2 diabetes. All patients with type 2 diabetes, 40 years old and over were recruited consecutively from diabetic clinics at a medical center. Serum lipid, creatinine, uric acid, CRP, HbA(1C) and urinary albumin concentration were measured. A total of 515 patients, aged 60.3 +/- 10.7 years were recruited and the number (rate) of micro- and macro-albuminuria were 109 (21.2%) and 55 (10.7%). The prevalence of micro-albuminuria for the quartiles of CRP levels demonstrated a meaningful trend of increases between groups from 17.4, 21.1, 30.3, and 31.2% (P trend = 0.002). Besides, the median CRP concentrations was significantly higher in the patients with micro- and macro-albuminuria than those with non-albuminuria. Stepwise logistic regression analysis revealed that CRP was significantly associated with abnormal albuminuria (OR = 1.36, 95% CI = 1.12-1.64, P = 0.002). After excluding those subjects with angiotensin-converting enzyme inhibitors/angiotension II receptor blockers or/and statin usage, the observed relationship between serum CRP levels and albuminuria was still persistent (OR = 1.61, 95% CI = 1.24-2.08, P < 0.001). In addition, hyperuricemia were significantly associated with abnormal albuminuria in the patients without diuretics, uricosuric agents or alcohol usage. Both serum CRP levels and hyperuricemia were significantly related to the presence of albuminuria in patients with diabetes. In addition, Chinese type 2 diabetic patients with serum CRP levels in the lower range as other ethnic groups can lead to the development of micro-albuminuria.

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Prevalence and Associated Features of Albuminuria in Koreans with NIDDM

Cited by 38 publications

References 25 publications

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Coronary artery disease, microalbuminuria and lipid profile in patients with non-insulin dependent diabetes mellitus

Association of C-reactive protein and hyperuricemia with diabetic nephropathy in Chinese type 2 diabetic patients

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