Prevalence and Clinical Profile of Human &lt;b&gt;&lt;i&gt;Salivirus&lt;/i&gt;&lt;/b&gt; in Children with Acute Gastroenteritis in Northern Italy, 2014–2015

Bergallo, Massimiliano; Daprà,; Rassu, Marco; Bonamin, Stefano; R, Cuccu; Calvi, Cristina; Montanari, Paola; Galliano, Ilaria

doi:10.1159/000490568

Cited by 9 publications

(8 citation statements)

References 27 publications

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“…Similar to that observed previously in Italy [26], in this study, the detection rate of SalV infections accounted for 0.5%. Although they are globally widespread, SalV seem to circulate more in Asia than in North Africa and Europe.…”

Section: Discussionsupporting

confidence: 92%

Bufavirus, Cosavirus, and Salivirus in Diarrheal Italian Infants

et al. 2021

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Three newly discovered viruses have been recently described in diarrheal patients: Cosavirus (CosV) and Salivirus (SalV), 2 picornaviruses, and bufavirus (BuV), a parvovirus. The detection rate and the role of these viruses remain to be established in acute gastroenteritis (AGE) in diarrheal Italian infants. From November 2016 to November 2017, stool samples were collected from 160 children <5 years old suffering from AGE and attending the Children’s Hospital in Turin, Italy. During the study period, 1 (0.5%) sample was positive for 1 of the 3 investigated viruses: 0 (0%) CosV, 1 (0.5%) SalV, and 0 (0%) BuV, whereas 42 (26.0%) children were infected with rotavirus and 2 (1%) with adenovirus. No mixed infections involving the 3 viruses were found. Although these viruses are suspected to be responsible for AGE in children, our data showed that this association was uncertain. Therefore, further studies with large cohorts of healthy and diarrheal children will be needed to evaluate their clinical role in AGE.

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Section: Discussionsupporting

confidence: 92%

Bufavirus, Cosavirus, and Salivirus in Diarrheal Italian Infants

et al. 2021

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“…According to different reports from various geographical regions, the prevalence of SaV was varied, Tunisia (1%), Italy (0.5%), Thailand (0.44%), Hong Kong (0.07%), Iran (0.7%), Brazil (1.7%) and 3.8% in Germany. 6,7,9,23,27,29 The results of reviewed studies about the association between SaV and GI complications contrast with each other. In all these studies, PCR-based methods, either (q)RT-PCR or RT-(nested) PCR, were commonly applied for the detection of SaV.…”

Section: Discussionmentioning

confidence: 99%

“…Diarrhoea is one of the manifestations of GI tract infection that can be caused by either bacterial or viral pathogens 5 . Besides known various viruses such as norovirus, astrovirus, rotavirus, adenovirus and enterovirus, SaV‐A might be related to GI complications and diarrhoea with a frequency of 0.1%– 8.8% 6–8 . SaV‐A infection was only reported in patients ˂20 years old with high prevalence in children aged under five 8,9 .…”

Section: Introductionmentioning

confidence: 99%

“…SaV was detected in stool samples collected in summer, autumn and winter in China and Hungary, Tunisia and Italy, respectively. Thereby, SaV infection represents no seasonal pattern and may occur in all seasons 6,15,16 . In addition to patients with GI complications, SaV was also detected in healthy/asymptomatic individuals 8,15 .…”

Section: Introductionmentioning

confidence: 99%

“…Thereby, SaV infection represents no seasonal pattern and may occur in all seasons. 6,15,16 In addition to patients with GI complications, SaV was also detected in healthy/asymptomatic individuals. 8,15 Consequently, in this systematic review and meta-analysis, we investigated the overall prevalence of SaV in symptomatic children as well as its potential association with GI complications and diarrhoea.…”

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confidence: 98%

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Salivirus infection: Systematic review and meta‐analysis of association with gastrointestinal symptoms in children

Kesheh

Khatami

Saadati

et al. 2021

Reviews in Medical Virology

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Salivirus (SaV) is a newly described member of the family Picornaviridae that has been associated with gastrointestinal (GI) symptoms, particularly in children. The aim of the present study was to evaluate the prevalence of SaV in symptomatic children and its potential association with GI complications. A systematic search was conducted from 01 December 2009 to 10 December 2020, in three major English databases, including Scopus, PubMed and Web of Science as well as Google scholar search engine. Random effect model-based overall prevalence and odds ratio (OR)were assessed in cross-sectional and case-control studies by STATA 14.1. The random effect model-based pooled prevalence of SaV was 1.6% (95% CI, 0.010-0.022%) and overall OR for all eight case-control studies indicated an association (3.19 with 95% confidence interval 1.35-7.57) that was not statistically significant, due to the small number of studies available. More comprehensive case-control studies in multiple geographies should be conducted on the prevalence of SaV in children.

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Ten different viral agents infecting and co‐infecting children with acute gastroenteritis in Southern Italy: Role of known pathogens and emerging viruses during and after COVID‐19 pandemic

Amoroso,

Pucciarelli,

Serra

et al. 2024

Journal of Medical Virology

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Acute gastroenteritis (AGE) represents a world public health relevant problem especially in children. Enteric viruses are the pathogens mainly involved in the episodes of AGE, causing about 70.00% of the cases. Apart from well‐known rotavirus (RVA), adenovirus (AdV) and norovirus (NoV), there are various emerging viral pathogens potentially associated with AGE episodes. In this study, the presence of ten different enteric viruses was investigated in 152 fecal samples collected from children hospitalized for gastroenteritis. Real time PCR results showed that 49.3% of them were positive for viral detection with the following prevalence: norovirus GII 19.7%, AdV 15.8%, RVA 10.5%, human parechovirus (HPeV) 5.3%, enterovirus (EV) 3.3%, sapovirus (SaV) 2.6%. Salivirus (SalV), norovirus GI and astrovirus (AstV) 1.3% each, aichivirus (AiV) found in only one patient. In 38.2% of feces only one virus was detected, while co‐infections were identified in 11.8% of the cases. Among young patients, 105 were ≤5 years old and 56.0% tested positive for viral detection, while 47 were >5 years old with 40.0% of them infected. Results obtained confirm a complex plethora of viruses potentially implicated in gastroenteritis in children, with some of them previously known for other etiologies but detectable in fecal samples. Subsequent studies should investigate the role of these viruses in causing gastroenteritis and explore the possibility that other symptoms may be ascribed to multiple infections.

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Prevalence and Clinical Profile of Human <b><i>Salivirus</i></b> in Children with Acute Gastroenteritis in Northern Italy, 2014–2015

Cited by 9 publications

References 27 publications

Bufavirus, Cosavirus, and Salivirus in Diarrheal Italian Infants

Bufavirus, Cosavirus, and Salivirus in Diarrheal Italian Infants

Salivirus infection: Systematic review and meta‐analysis of association with gastrointestinal symptoms in children

Ten different viral agents infecting and co‐infecting children with acute gastroenteritis in Southern Italy: Role of known pathogens and emerging viruses during and after COVID‐19 pandemic

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