Prevalence and genotype distribution of HPV and cervical pathological results in Sichuan Province, China: a three years surveys prior to mass HPV vaccination

Luo, Qin; Jiang, Ni; Wu, Qiaoyuan; Wang, Jiaqiang; Zhong, Jialing

doi:10.1186/s12985-020-01366-2

Cited by 19 publications

(34 citation statements)

References 29 publications

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“…We found that the distribution of high-risk HPV genotypes is directly related to the severity of cervical cytopathology. By analyzing the cytology results of 3,912 patients, it was found that regardless of AGC, ASC-H, ASC-US, LSIL, or HSIL cytology samples, HPV 16, 58, and 52 were always the major type, with variations in rank varied, which was consistent with the data in other studies [ 15 , 38 ]. Furthermore, we noticed that patients infected with HPV 16, 18, 56, 58 or 66 have an increased risk of causing abnormal cytological results.…”

Section: Discussionsupporting

confidence: 88%

Prevalence, characteristics, and distribution of HPV genotypes in women from Zhejiang Province, 2016–2020

Yan

Shen

Xiao

et al. 2021

Virol J

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Objective To evaluate and understand the prevalence of HPV genotypes and characteristics of female populations in specific areas and the relationship with cervical lesions, which can effectively guide cervical cancer screening and formulate HPV vaccine prevention strategies. Methods A total of 77,443 women who visited gynecological clinics and underwent health examinations in the Second Affiliated Hospital of Zhejiang University School of Medicine during 2016–2020 were enrolled in this survey. Cervical samples were collected for HPV DNA genotyping and cervical cytology testing. Cervical biopsies were performed for patients with visible cervical abnormality or abnormal cytological results. Results The results showed the 5-year overall positive rate was 22.3%, of which the gynecology clinic group had significantly more positive results compared with the health examination group (P < 0.001). The five most common genotypes in Zhejiang Province were HPV 52, 58, CP8304, 16, and 51 (23.9%, 12.7%, 11.7%, 11.7% and 9.3%). HPV infection was age-specific, with the highest infection rate in the age group ≤ 20 compared to other age groups (P < 0.001). HPV infection was also season-specific, with the highest infection rate in spring or winter. The main HPV infection mode was single infection (P = 0.004), but patients ≤ 20 years old were more likely to develop multiple infections (51.0%). HPV 16, 52 and 58 were the main genotypes that caused cytological abnormalities and HPV16, 18, 56, 58 and 66 were independent risk factors for cervical lesions (OR = 2.352, 1.567, 2.000, 1.694, 1.889; all P < 0.05). Further analysis found HPV 16 and 18 were the main genotypes that cause cervical cancer histological abnormalities and were independent risk factors for cervical cancer (OR = 5.647, P < 0.001; OR = 3.495, P = 0.036). Conclusion This article analyzed the prevalence of distribution characteristics of HPV infection and revealed the corelation between HPV infection and cytological and histological abnormalities. Comprehensive results of this survey will help Zhejiang Province to formulate public health policies and provide evidence for future selection of specific HPV vaccines.

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Section: Discussionsupporting

confidence: 88%

Prevalence, characteristics, and distribution of HPV genotypes in women from Zhejiang Province, 2016–2020

Yan

Shen

Xiao

et al. 2021

Virol J

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“…In addition, HPV infection rates differ across regions in China [ 6 – 8 ] Here, we analyzed the HPV prevalence trends from 2016 to May 2021 and found that the overall infection rate was 18.10% (Table 1 ). This is higher than reported in Yunnan (12.9%) [ 6 ], Shanghai (17.92%) [ 8 ], Xinjiang (14.02%) [ 9 ], and Huzhou (15.5%) [ 10 ], and lower than reported in Guangzhou (26.0%) [ 7 ], Sichuan (23.84%) [ 11 ], and Chongqing (19.9%) [ 12 ]. In addition to cultural background and living habits, ethnicity may be an important contributing factor to HPV prevalence in different regions.…”

Section: Discussionmentioning

confidence: 57%

“…The results of this study showed that HPV 52, 16, 58, 51, 39, and 53 were the most common genotypes in the Guangxi Chinese population. This finding is consistent with the results reported in Shanghai [ 8 ] and different from those in other Chinese cities, such as Meizhou (HPV 52, 16, 58, 39, 53, and 18) [ 23 ], Xinjiang (HPV 16, 52, 58, 53, 31, and 39; HPV 51 ranks tenth among HR-HPV infections) [ 9 ], Yunnan (HPV 16, 33, 52, 31, 58, and 39) [ 13 ], Beijing (HPV 16, 58,33,52, 18, and 31) [ 17 ], and Sichuan (HPV 52, 53, 58, 16, 56, and 39) [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

Liu-ting

Qin

et al. 2022

Infect Agents Cancer

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Background Human papillomavirus is a primary cause of cervical cancer and genital warts. HPV vaccine can prevent high-grade cervical lesions as well as cervical cancer. The aim of this study was to analyze the prevalence and genotype distribution of human papillomavirus among women in Guangxi before and after the HPV vaccine was approved for use in China. Methods From January 2016 to May 2021, 41,140 women were tested for HPV infection. HPV genotyping included 15 high-risk HPV (HR-HPV) and 6 low-risk HPV (LR-HPV) genotypes. Total prevalence, annual trend, and specific age group prevalence and genotype distribution were analyzed. Results The overall HPV infection rate was 18.10% among Guangxi women self-referred to clinic for gynecologic problems in southern China. During 2016–2018, the prevalence of HPV infection showed an upward trend, from 18.21% in 2016 to 21.99% in 2018, and later it showed a downward trend, from 18.35% in 2019 to 12.26% in May 2021. Pure HR-HPV genotypes (14.36%) were found in more infections than pure LR-HPV genotypes (2.77%) and mixed genotypes (0.97%). Two peaks of HPV infection were found in the ≤ 25 years (22.94%) and 56–65 years (21.25%) groups. The six most prevalent HR-HPV genotypes were HPV 52 (4.06%), 16 (2.70%), 58 (2.24%), 51 (1.87%), 39 (1.52%), and 53 (1.52%). The three most prevalent LR-HPV genotypes were HPV 6 (1.31%), CP8304 (1.01%), and 11 (0.82%). Infection with a single HR-HPV genotype was the most common type of infection, with an overall infection rate of 12.30%. Infection with two HPV genotypes was the most common multiple HR-HPV infection type, with an infection rate of 2.35%. Conclusions The cervical HPV infection rate of women in Guangxi is very high, and there is significant age specificity. There is a need to increase HPV vaccination of young people and the screening of middle-aged and elderly people.

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“…[ 15 ] In China, previous studies have revealed that the most common HPV genotypes are HPV16, HPV52, and HPV33 in Yunnan, [ 16 ] HPV16, HPV58, and HPV52 in Beijing, [ 17 ] HPV16, HPV52, and HPV58 in Xinjiang, [ 9 ] HPV52, HPV16, and HPV58 in Jiangsu, [ 18 ] and HPV52, HPV58, and HPV16 in Sichuan. [ 19 ] In the present study, we investigated the prevalence of HPV in 940 patients with LSIL, HSIL and SCC in Taizhou. The prevalence of any HPV, HR-HPV, and LR-HPV was 83.83%, 81.91%, and 12.13%, respectively.…”

Section: Discussionmentioning

confidence: 99%

The prevalence and genotype distribution of human papilloma virus in cervical squamous intraepithelial lesion and squamous cell carcinoma in Taizhou, China

et al. 2021

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Human papillomavirus (HPV) infection is a common sexually transmitted disease worldwide and the leading cause of cervical cancer. Current vaccines do not cover all HPV genotypes whereas the distribution of HPV genotypes varies in different geographic regions. The study aimed to investigate the distribution of HPV genotypes in patients with cervical squamous intraepithelial lesion (SIL) and cervical squamous cell carcinoma (SCC) in Taizhou City of Jiangsu Province, China. A total of 940 patients including 489 cases with cervical low-grade squamous intraepithelial lesions (LSIL), 356 cases with cervical high-grade squamous intraepithelial lesions (HSIL), and 95 cases with cervical SCC, underwent a biopsy or surgery in Taizhou People's Hospital between January 2019 and December 2019. The HPV testing results were retrospectively analyzed. The overall prevalence of any, high-risk, and low-risk HPV was 83.83%, 81.91%, and 12.13%, respectively. The 5 most common HPV genotypes were HPV16 (35.64%), HPV52 (16.91%), HPV58 (13.94%), HPV33 (8.94%), and HPV18 (7.98%). The prevalence of any and HR-HPV in SCC was significantly higher than those in LSIL and HSIL, while the prevalence of LR-HPV in SCC was significantly lower than those in LSIL and HSIL ( P < .01). Single and dual HPV infections were prevalent in SCC, LSIL, and HSIL. Furthermore, the prevalence of dual HPV infection in SCC was significantly higher than those in LSIL and HSIL ( P = .002). The HPV prevalence varied by age, being highest among women with SCC, LSIL, and HSIL aged 40 to 49 years, 40 to 49 years, and 50 to 59 years, respectively. In conclusion, the findings revealed a very high prevalence of HPV in women with cervical lesions in Taizhou. Routine HPV tests must cover all common HPV genotypes in clinical practice.

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Prevalence and genotype distribution of HPV and cervical pathological results in Sichuan Province, China: a three years surveys prior to mass HPV vaccination

Cited by 19 publications

References 29 publications

Prevalence, characteristics, and distribution of HPV genotypes in women from Zhejiang Province, 2016–2020

Prevalence, characteristics, and distribution of HPV genotypes in women from Zhejiang Province, 2016–2020

The prevalence and genotype distribution of human papillomavirus among women in Guangxi, southern China

The prevalence and genotype distribution of human papilloma virus in cervical squamous intraepithelial lesion and squamous cell carcinoma in Taizhou, China

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