Prevalence and Incidence of Non-alcohol Fatty Liver Disease in Chronic Hepatitis B Population in Southeast China: A Community-Based Study

Zheng, Yang; Xu, Kaijin; Hu, Haiyang; Draz, Mohamed Shehata; Wu, Wei; Li, Lanjuan

doi:10.3389/fmed.2021.683872

Cited by 3 publications

(3 citation statements)

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“…The nationwide prevalence of NAFLD increased by 10% within 10 years, as opposed to an increase of only 5.5% in the United States over 20 years 8 . Taking Shanghai as an example, the prevalence of NAFLD increased from 17.3% in 2005 to 43.7% in 2015 and remained at 40.5% in 2017 8,9 . The prevalence of NAFLD is unevenly distributed across various provinces/regions, with the lowest in Hainan and the highest in Liaoning, Fujian, Hong Kong and Taiwan (Figure 1).…”

Section: The Prevalence and Incidence Of Nafld/nash In Chinamentioning

confidence: 99%

“…8 Taking Shanghai as an example, the prevalence of NAFLD increased from 17.3% in 2005 to 43.7% in 2015 and remained at 40.5% in 2017. 8,9 The prevalence of NAFLD is unevenly distributed across various provinces/ regions, with the lowest in Hainan and the highest in Liaoning, Fujian, Hong Kong and Taiwan (Figure 1). Notably, data from the provinces/ regions Ningxia, Gansu, Qinghai, Tibet and Hainan are of poor quality and lack population representativeness, while no data have been published in Macau, Jiangxi and Guizhou.…”

Section: The Prevalence and Incidence Of Nafld/nash In Chinamentioning

confidence: 99%

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Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review

Liu

Hong

2023

Diabetes Obesity Metabolism

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Aim With industrialization and spread of the westernized lifestyle, the number of people affected by non‐alcoholic fatty liver disease (NAFLD)/non‐alcoholic steatohepatitis (NASH) is growing rapidly in China; this has become a major public health concern. To better understand the burden and characteristics of NAFLD/NASH in China, we aim to perform a narrative review of the literature published in this field. Materials and Methods We carried out a comprehensive electronic search of five English‐language and three Chinese‐language databases, to identify studies regarding NAFLD or NASH published from inception to November 30, 2022. Epidemiological studies of NAFLD/NASH in China were particularly noticed and summarized. We also searched the http://www.clinicaltrials.gov and http://www.chictr.org.cn websites for the registered trials on the treatment of the disease led by Chinese investigators or located in China. Results The increasing rate of NAFLD prevalence in China is strikingly high, reaching more than twice that in western countries. The prevalence of NAFLD is nearly 30% of the general Chinese population, making it the leading cause of chronic liver diseases. The prevalence of NAFLD/NASH varies between provinces/regions, age groups, sexes, and individuals with different metabolic profiles. NAFLD co‐exists in many Chinese patients with chronic hepatitis B. Since 2020, more Chinese studies have used the term metabolic‐associated fatty liver disease (MAFLD), emphasizing the underlying metabolic disorders that occur concurrently with this disease. Several clinical trials involving lifestyle interventions, antidiabetic drugs, or traditional Chinese medicines, registered by Chinese investigators, have been completed or are ongoing. Moreover, several innovative targeted therapies developed in China are revolutionizing the treatment of NAFLD/NASH. Conclusions NAFLD has cast a heavy burden on the Chinese healthcare system. Chinese scholars are making efforts to achieve the optimal management of this disease.

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Section: The Prevalence and Incidence Of Nafld/nash In Chinamentioning

confidence: 99%

Section: The Prevalence and Incidence Of Nafld/nash In Chinamentioning

confidence: 99%

Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review

Liu

Hong

2023

Diabetes Obesity Metabolism

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“…6 In addition, approximately 25%-40% of people with CHB infection also suffer from steatotic liver disease (SLD), which is another common CLD with constantly increasing prevalence. [7][8][9] Hepatic steatosis (HS) potentially leads to severe liver-related complications such as cirrhosis, liver cancer, and mortality. 10,11 CHB and SLD are two of the most prevalent liver-related diseases worldwide.…”

Section: Introductionmentioning

confidence: 99%

Impact of hepatic steatosis on risk of acute liver injury in people with chronic hepatitis B and SARS‐CoV‐2 infection

Chung,

Wong,

et al. 2024

Liver International Communications

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BackgroundSARS‐CoV‐2 infection was known to be associated with higher risk of liver impairment in people with chronic hepatitis B infection (CHB). However, evidence regarding the impact of concomitant hepatic steatosis (HS) on the risk of liver disease among people with CHB and SARS‐CoV‐2 infection is lacking. We investigated the impact of concomitant HS on people with CHB suffering from SARS‐CoV‐2 infection.MethodsThis retrospective cohort study was performed using an electronic health database for people in Hong Kong with CHB and confirmed SARS‐CoV‐2 infection between 21 January 2020 and 31 January 2023. People with HS diagnosis (HS + CHB + COVID‐19) were identified and matched 1:1 by propensity score with those without (CHB + COVID‐19). Each person was followed up until death, outcome event, or 31st January 2023. Study outcome was incidence of acute liver injury (ALI) within first 28 days since COVID‐19 diagnosis. Severity of ALI and comparison of ALI risk stratified by the presence of CHB infection and HS were also analysed. Incidence rate ratios (IRRs) were estimated by Poisson regression models.ResultsOf 52 259 COVID‐19 patients with CHB infection in the cohort, 15 391 people with HS + CHB + COVID‐19 and 15 391 people with CHB + COVID‐19 were included after matching. HS + CHB + COVID‐19 was associated with increased risk of ALI (IRR: 1.41, 95% CI:1.05–1.90, p = 0.023), compared to CHB + COVID‐19. Over 99% ALI cases were mild to moderate severity, and there were no differences in the severity of ALI between HS + CHB + COVID‐19 and CHB + COVID‐19 (p = 0.127).ConclusionsConcomitant HS was associated with increased risk of ALI among people with CHB infection suffering from SARS‐CoV‐2 infection.

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Predictors of Hepatocytes Cytolysis of Insulin Resistant Rats Under Conditions of Pre- And Postnatal Iodine Deficiency

Stetseviat¹,

Voronych-Semchenko²,

Bahrii³

et al. 2023

Fiziol Zh

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Carbohydrate metabolism markers, thyroid profile indexes, transaminase activity and structural features of liver were studied, taking into account sexual dimorphism, in rats which were keeping on a high-fructose diet under conditions of adequate iodine supply and pre- and postnatal iodine deficiency. It was found that under fructose loading of animals with iodine deficiency the risk of insulin resistance (IR) development increases (HOMA-IR index in insulin-resistant male rats under conditions of pre- and postnatal iodine deficiency increases respectively by 22 and 13% compared to the data in animals that received a high-carbohydrate diet and adequate iodine supply). It is important, that in males and females with IR, the secretion of free triiodothyronine decreased by 36 and 40%, thyroid-stimulating hormone – by 28 and 34%, respectively, compared to the data of intact animals. The development of IR was accompanied by the activation of aminotransferases in blood serum (more in males). In particular, in male rats with IR under conditions of pre- and postnatal iodine deficiency, the activity of aspartate aminotransferase increased by 2.7 and 2.4 times, alanine aminotransferase – by 3.9 and 2.7 times, respectively, which led to a decrease of the de-Ritis index (more significantly against the background of prenatal iodine deficiency – by 25%) in relation to the data in animals that were on a standard diet. The activity of aminotransferases in rats with IR under conditions of iodine deprivation was higher than in animals with isolated iodine deficiency – by 11-56% and IR – by 13-47 %. In animals with IR, the presence of binucleated hepatocytes with a diffuse decrease in the number of glycogen granules in them and accumulation of glycoproteins in the wall of liver vessels were found. The foci of fatty dystrophy and pronounced zonal character of dystrophic processes in hepatocytes were identified in females, diffuse dystrophy prevailed in males. In the cytoplasm of hepatocytes of animals with IR under conditions of prenatal iodine deficiency, the lightening and the granularity, single granules of glycogen were observed. Under these conditions, the average perimeter (by 74%) and area (by three times) of hepatocytes, the average area of nucleus (by 3.1 times), the average perimeter (by 50%) and area (by 66%) of the nucleolus were increased compared to the control values. The structural changes were consistent with an increase of the transaminase activity. Thus, fructose loading and the development of IR acts as a trigger for cytolysis of hepatocytes, which increases under conditions of iodine deficiency, especially prenatal.

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Prevalence and Incidence of Non-alcohol Fatty Liver Disease in Chronic Hepatitis B Population in Southeast China: A Community-Based Study

Cited by 3 publications

References 28 publications

Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review

Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review

Impact of hepatic steatosis on risk of acute liver injury in people with chronic hepatitis B and SARS‐CoV‐2 infection

Predictors of Hepatocytes Cytolysis of Insulin Resistant Rats Under Conditions of Pre- And Postnatal Iodine Deficiency

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