Prevalence and multiplicity of HPV in HIV women in Minas Gerais, Brazil

BACKGROUND Increasing evidence suggests that human papillomavirus (HPV) intratype variants (specific lineages and sublineages) are associated with pathogenesis and progression from HPV infection to persistence and the development of cervical cancer.OBJECTIVES This study aimed to verify the prevalence of HPV infection and distribution of HPV types and HPV16 variants in southern Brazil in women with normal cytology or intraepithelial lesions.METHODS HPV typing was determined by L1 gene sequencing. To identify HPV16 variants, the LCR and E6 regions were sequenced, and characteristic single nucleotide variants were identified.FINDINGS A total of 445 samples were studied, with 355 from cervical scrapes and 90 from cervical biopsies. HPV was detected in 24% and 91% of these samples, respectively. The most prevalent HPV types observed were 16 (cervical, 24%; biopsies, 57%) and 58 (cervical, 12%; biopsies, 12%). Seventy-five percent of the HPV16-positive samples were classified into lineages, with 88% defined as lineage A, 10% as lineage D, and 2% as lineage B.MAIN CONCLUSIONS This study identified a high frequency of European and North American HPV16 lineages, consistent with the genetic background of the human population in southern Brazil.

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“…2006). In Brazil, HPV16 is also the most common type detected in HIV-positive women (Corrêa et al 2011), as we found in the current study.…”

Section: Discussionsupporting

confidence: 83%

“…The association between HPV and HIV infections is well documented (Houlihan et al 2012), with the prevalence of HPV infection higher in HIV-positive women (Corrêa et al 2011, Menon et al 2016). In this study, the frequency of HPV infection in HIV-positive women was also higher than that in HIV-negative women.…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus type distribution and HPV16 intratype diversity in southern Brazil in women with and without cervical lesions

Oliveira

Vieira

Avila

et al. 2017

Mem. Inst. Oswaldo Cruz

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“…Although most studies show that HPV-16 genotype is the most prevalent worldwide, 21 this data is in line the report by Corrêa et al, who observed a prevalence of 63.9% of HPV-6 genotype followed by HPV-16 genotype as the second most prevalent (48.5%). 24 Levi et al observed similar data, with higher prevalence of HPV-6 genotype in HIV-infected women (87%). 25 McKenzie et al, in a meta-analysis study, observed that different geographic areas, such as Zambia, Brazil and Rochester (New York, United States), show different HR-HPV infections by less prevalent genotypes when compared to the population in general.…”

Section: Discussionmentioning

confidence: 65%

Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil

Entiauspe

Seixas

Nunes

et al. 2014

The Brazilian Journal of Infectious Diseases

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The data obtained suggest that HIV-infected women are more susceptible to be infected by low-risk HPV (LR-HPV) genotypes than by high-risk (HR-HPV), and Pro72Pro of TP53 gene and TG of MDM2 SNP309 genotypes apparently seem to be protective factors among HIV-infected women for HPV acquisition and HR-HPV infection, respectively, in a sample of Southern Brazilian woman. Future investigations in larger populations are necessary to better understand the potential roles of these SNPs and the behavior of non-oncogenic HPV genotypes in HIV-mediated immunosuppression cases.

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Epidemiological and Cytopathological Profile of Dysplastic Lesions of the Cervix in South-Kivu/Dr Congo

Nyakio¹,

Fabrice²,

Albert³

et al. 2021

OJOG

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Background: Cervical cancer is one of the most common cancers in women in the world. The recrudescence of dysplastic lesions is increasing, especially in developing countries, because of the absence of screening. The objective of this work is to determine the prevalence of dysplastic lesions of the cervix in women who are sexually active in South Kivu province. Methods: It was a cross-sectional, descriptive and analytical study of 625 women who came for gynecological consultation, all of whom had cervical-uterine Pap smears, during the period from January 1st, 2017 to December 31st, 2018 at Panzi General Referral Hospital (South Kivu, DR Congo). Data analysis was done using Epi Info software version 7. Results: The median age of the respondents was 34 years, 47.0% of them were married, and 59.0% had a low socioeconomic level. The majority had first sexual intercourse between the ages of 15 and 20 (67.5%), a number of former sexual partners estimated at 1-5 (87.8%), did not use tobacco (97.4%) and did not use contraception (78.1%). Pap smear was normal in 82.88% of cases, inflammatory in 2.4% of cases and with cytologic abnormalities in 14.72% of cases. Rates of dysplastic lesions were significantly higher among women aged ≥35 years (p = 0.0245), brides (p = 0.0183) and nulliparas (p = 0.0042). Multivariate analysis revealed the adjusted OR (95% CI) statistically insignificant (p < 0.05) for the age group, marital status and parity respondents. Conclusion: Cervical cancer How to cite this paper:

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Prevalence and multiplicity of HPV in HIV women in Minas Gerais, Brazil

Cited by 4 publications

References 21 publications

Human papillomavirus type distribution and HPV16 intratype diversity in southern Brazil in women with and without cervical lesions

Human papillomavirus type distribution and HPV16 intratype diversity in southern Brazil in women with and without cervical lesions

Uncommon non-oncogenic HPV genotypes, TP53 and MDM2 genes polymorphisms in HIV-infected women in Southern Brazil

Epidemiological and Cytopathological Profile of Dysplastic Lesions of the Cervix in South-Kivu/Dr Congo

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