Prevalence and predictors of impaired fasting glucose among Nigerian patients with hepatitis B virus infection

Iroezindu, Michael; Isiguzo, Godsent; Young, Ekenechukwu

doi:10.1016/j.diabres.2012.08.006

Cited by 7 publications

(11 citation statements)

References 38 publications

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“…Previous studies have already shown that hepatitis C virus (HCV) infection is a risk factor for developing type 2 diabetes. Some studies have shown that chronic hepatitis B virus (HBV) infection (CHB) is also related to an increased risk of diabetes in certain ethnic populations, such as Asian Americans, and associated with increased impaired fasting glucose among Nigerians. A study in Hong Kong showed that hepatitis B surface antigen (HBsAg) carrier status was an independent risk factor for gestational diabetes.…”

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis B virus infection status is more prevalent in patients with type 2 diabetes

Lü

Hou

et al. 2017

J of Diabetes Invest

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Aims/IntroductionIt has not been reported whether chronic hepatitis B virus infection (CHB) is associated with a specific type of diabetes. We sought to investigate the prevalence of CHB status in different diabetes subtypes among a Chinese population.Materials and MethodsThis was a cross‐sectional study. A total of 381 patients with adult‐onset autoimmune diabetes, 1,365 patients with type 2 diabetes and 1,365 non‐diabetic controls were recruited from June 2005 to February 2014. The exclusion criteria included: (i) hepatitis C virus antibody positive; (ii) hepatic cirrhosis; and (iii) malignant neoplasm and severe renal dysfunction (serum creatinine >450 μmol/L). Patients were grouped as hepatitis B virus‐negative and CHB status.ResultsPatients with type 2 diabetes had a higher prevalence of CHB than the controls in the overall population (13.5 vs 10.0%, P = 0.004) and among patients with normal hepatic function (13.3 vs 8.8%, P = 0.002). There was no difference in the prevalence of CHB status between patients with adult‐onset autoimmune diabetes and the controls. Multiple logistic regression analysis showed that the odds ratio of CHB increased by ~1.5‐fold in patients with type 2 diabetes than in the control group after adjustment for age, sex and body mass index, regardless of hepatic function status.Conclusions CHB status was more prevalent in patients with type 2 diabetes than in individuals with adult‐onset autoimmune diabetes and the controls among the Chinese population. Further research is required to ascertain whether CHB status increases the risk of developing type 2 diabetes, or whether type 2 diabetes, but not adult‐onset autoimmune diabetes, increases the risk of CHB.

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Section: Introductionmentioning

confidence: 99%

Chronic hepatitis B virus infection status is more prevalent in patients with type 2 diabetes

Lü

Hou

et al. 2017

J of Diabetes Invest

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“…There is even less information on the prevalence of prediabetes. In one study, approximately 26% of Nigerians with chronic HBV had IFG . The reported factors associated with abnormalities of glucose metabolism have included both host and viral factors .…”

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confidence: 99%

Diabetes and prediabetes in patients with hepatitis B residing in North America

Hbrn

2015

Hepatology

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Diabetes is associated with liver disease progression and increased hepatocellular carcinoma risk, but factors associated with diabetes in patients with chronic hepatitis B virus (HBV) infection in North America are unknown. We aimed to determine factors predictive of diabetes and impaired fasting glucose (IFG) in a large HBV-infected multiethnic cohort. Adults with chronic HBV not receiving antiviral therapy were enrolled from 21 centers in North America. Diabetes was defined by history/medication use or fasting glucose ≥126 mg/dL and IFG as fasting glucose 100–125 mg/dL. Of 882 patients included, 47.2% were female, 71.3% Asian, 83.7% foreign born, median age was 44 years, and median body mass index BMI 24.3 kg/m2. In this cohort, 26.0% were hepatitis B envelope antigen (HBeAg) positive, 43.9% had HBV DNA ≥20,000 IU/mL, and 26.7% alanine aminotransferase (ALT) ≥2× upper limit of normal (≥40 U/L women, ≥60 U/L men). Overall, 12.5% had diabetes and 7.8% IFG. The combined prevalence of diabetes or IFG was highest among blacks (36.7%) and those either born in the United States/Canada or foreign born with migration >20 years ago (25.5%). Obesity (odds ratio [OR]: 2.13), hyperlipidemia (OR, 4.13), hypertension (OR, 3.67), high ALT level (OR, 1.86), and family history of diabetes (OR, 3.43) were associated with diabetes. Factors associated with IFG were obesity (OR, 4.13) and hypertension (OR, 3.27), but also HBeAg positivity (OR, 0.39). Recent migration was negatively associated with diabetes among non-Asians (OR, 0.30). Conclusions Diabetes is more prevalent in HBV-infected North American adults than the general population and is associated with known metabolic risk factors and liver damage, as determined by ALT levels. Among the foreign born, longer duration of North America residence predicted diabetes risk in non-Asians. These results highlight the opportunities for interventions to prevent diabetes especially among at-risk ethnic groups with HBV.

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“… 30 Several previous studies have shown that high levels of liver enzymes such as ALT, or dyslipidemia are related to IFG or diabetes in HBV/HCV carriers. 31 – 33 Our results indicate that elevated ALT or TG levels even below the threshold of abnormality can increase the risk for impaired glucose tolerance. Thus, close monitoring of liver enzymes and lipid profile to enable early control of elevated ALT and TG levels may be crucial for the prevention of impaired glucose tolerance in HBV carriers.…”

Section: Discussionmentioning

confidence: 71%

“…Other factors that were significantly associated with impaired glucose tolerance in our study, including male sex, older age, and being overweight, are well-known risk factors for the development of diabetes in the general population 34 , 35 and in viral hepatitis carriers. 23 , 31 , 36 , 37 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of and Factors Influencing Impaired Glucose Tolerance Among Hepatitis B Carriers

Park

Jung

et al. 2014

Medicine

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Diabetes is associated with a poor prognosis for liver disease, particularly in chronic hepatitis carriers. We investigated the prevalence of factors associated with impaired glucose tolerance (IGT) including diabetes and impaired fasting glucose (IFG) among individuals with hepatitis B virus (HBV) infection.We used data from the Korean National Health and Nutrition Examination Survey, a nationwide cross-sectional survey conducted between 2007 and 2011. Sociodemographic information was collected using a structured questionnaire. The HBV surface antigen, liver enzymes, and lipid profile were measured from blood samples.IFG was found in 18.1% of HBV carriers and 19.3% of noncarriers (P = 0.25). Diabetes was observed in 10.0% of HBV carriers and 12.2% of noncarriers (P = 0.08). Lower level of educational attainment was associated with a higher prevalence of IGT: high school education (odds ratio [OR] = 1.94 [95% confidence interval (CI) 1.14–3.29] and less than a high school education (OR = 3.20 [95% CI, 1.66–6.15] vs more than or equal to a college education. Elevated alanine transaminase and triglyceride by 10 were associated with increased risk of IGT (OR = 1.10 [95% CI, 1.01–1.20] and OR = 1.04 [95% CI, 1.01–1.07], respectively). Being a man and older in age were associated with a higher prevalence of IGT, and individuals with a low body mass index were at lower risk for IGT.Given the synergistic effect of diabetes and HBV infection on liver disease prognosis, we recommend targeted IGT screening and follow-up for HBV carriers. These efforts should include health policies and intervention programs aimed at reducing educational disparities and encouraging early control of elevated liver enzymes or lipid profiles.

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Prevalence and predictors of impaired fasting glucose among Nigerian patients with hepatitis B virus infection

Cited by 7 publications

References 38 publications

Chronic hepatitis B virus infection status is more prevalent in patients with type 2 diabetes

Chronic hepatitis B virus infection status is more prevalent in patients with type 2 diabetes

Diabetes and prediabetes in patients with hepatitis B residing in North America

Prevalence of and Factors Influencing Impaired Glucose Tolerance Among Hepatitis B Carriers

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