Prevalence and relevance of contact dermatitis allergens: A meta-analysis of 15 years of published T.R.U.E. test data

Krob, H.Alexander; Fleischer, Alan B.; D’Agostino, Ralph B.; Haverstock, Christina L.; Feldman, Steven R.

doi:10.1016/j.jaad.2003.11.069

Cited by 93 publications

(52 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…20,21 Both the Mayo Clinic and North American Contact Dermatitis Group reported patch-test positive rates of less than 3% for tixocortol pivalate and of 1.6% for budesonide in a general patch-test population. 20,21 Similarly low reaction rates for topical corticosteroids have been found in patch-test studies focusing on vulval dermatoses. 2,3 Considering the widespread use of topical corticosteroids to irritated and inflamed skin and mucous membranes, it is reassuring that true allergic contact sensitivity appears to be relatively rare.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prospective study of patch testing in patients with vulval pruritus

et al. 2008

View full text Add to dashboard Cite

SUMMARYForty-three patients with the primary complaint of vulval pruritus were recruited to take part in this prospective patch-testing study. A detailed questionnaire was administered to each and patch testing to an extended battery of allergens was undertaken. This included the European standard series, preservatives, corticosteroids and a battery of common over-the-counter topical vulval treatments. Analysis of demographic data and prior treatments used, and various other parameters, were studied in the context of patch-test results. This prospective study reports a very high rate of contact sensitivity in patients presenting with vulval pruritus, with 81.4% of those tested having at least one contact allergen detected. One or more clinically relevant allergens were found in 44% of the subjects patch tested. The variables found to predict a greater likelihood of a contact allergy were a biopsy diagnosis of vulval dermatitis, the use of multiple topical treatments, sexual inactivity and patients with severe pruritus on a selfreported scale. Most importantly, many clinically relevant allergens these patients reacted to were outside the European standard series. This highlights the need for an extended series in this patient population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prospective study of patch testing in patients with vulval pruritus

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The clinician then grades the patient's reaction to the allergens according to intensity and evaluates the reaction for clinical relevance. 20 When the patch-testing procedure was applied, this patient had a positive reaction to nickel (ϩϩϩϩ) and thiomersal (ϩϩ), which are among the most prevalent allergens causing allergic contact dermatitis, based on both the thin-layer rapid use epicutaneous test data and the North American Contact Dermatitis Group data. 20 Thiomersal is a chemical substance used as a preservative in certain cosmetics and in drugs such as ear and nose drops.…”

Section: Discussionmentioning

confidence: 99%

“…20 When the patch-testing procedure was applied, this patient had a positive reaction to nickel (ϩϩϩϩ) and thiomersal (ϩϩ), which are among the most prevalent allergens causing allergic contact dermatitis, based on both the thin-layer rapid use epicutaneous test data and the North American Contact Dermatitis Group data. 20 Thiomersal is a chemical substance used as a preservative in certain cosmetics and in drugs such as ear and nose drops. According to the International Research Contact Dermatitis Group guidelines, described in Menezes et al, 21 with regards to the reading of patch tests, a score of positive 4 (being the most severe of all reactions) is characterized by the presence of erythema, edema, papules, and vesicles at the testing area, whereas a score of positive 2 presents only an erythema, thus indicating a less intense allergic response to that allergen.…”

Section: Discussionmentioning

confidence: 99%

A Severe Reaction to Ni-Containing Orthodontic Appliances

Kolokitha

Chatzistavrou

2009

The Angle Orthodontist

View full text Add to dashboard Cite

Exposure to nickel-containing orthodontic appliances may cause intra-or extraoral allergic reactions. Nickel is the most typical antigen implicated in causing allergic contact dermatitis, which is a Type IV delayed hypersensitivity immune response. This report presents an unusual reaction to nickel during the orthodontic treatment of an adult female patient. The patient had no previous history of allergy and had been wearing fixed metal upper appliances while in orthodontic treatment to assist the eruption of her impacted teeth. The adverse hypersensitivity reactions appeared only after the surgical exposure and included severe signs of eczematic and urticarial reactions of the face with redness, irritation, itching, eczema, soreness, fissuring, and desquamation as well as intraoral diffuse red zones. Diagnostic patch testing performed by the allergist revealed sensitization to nickel (ϩϩϩϩ score). Treatment was achieved with nickel-free appliances. (Angle Orthod. 2009;79:186-192.)

show abstract

“…A possible explanation may be related to non-specific chemical effects of CPI-613, since this compound has some detergent-like structural properties. High local concentrations of detergents (which occur at the site of injection) can induce local inflammation-like effects (Krob et al, 2004;Shaw et al, 2004). Another possible explanation is that, although selectively effective against tumor cells, high concentration (as occurs at the site of injection) can induce adverse effects or death in normal cells, leading to inflammation.…”

mentioning

confidence: 99%

Uncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel Mechanism

Maturo¹

2010

American Journal of Pharmacology and Toxicology

View full text Add to dashboard Cite

Problem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments of multiple toxicological parameters (including clinical signs as well as full panel blood work, necropsy and histology) at multiple times in animals treated with the threshold dose (i.e., a dose that did not induce significant effects), toxic dose (i.e., a dose that induced significant toxic effects) and dose that approximated the LD 10 dose (i.e., a dose that induced death in approximately 10% of the animals). CPI-613 was given intravenously 2x weekly for 3 weeks, a dosing schedule that is used in clinical trials of CPI-613. CPI-613-treated animals were compared to absolute control treatment as well as vehicle treatment. Furthermore, the correlations among toxic effects of CPI-613, plasma concentrations and Pharmacokinetics (PK) of CPI-613 were evaluated to establish the TK effects of CPI-613. Results: The results demonstrated the uncommon toxicological profile at toxic doses of CPI-613, which were related to induction of inflammation as the primary and the only toxicological effects in both animal species. The induction of inflammation was consistent with the dose-related increases in plasma CPI-613. Other changes such as elevations in reticulocytes and Gamma-Glutamyl Transferase (GGT) were also observed, but they might be secondary to the inflammatory effects of CPI-613. The toxic doses of CPI-613 were ~60x the anti-tumor dose levels observed in mouse tumor xenograft models, suggesting a wide safety margin of CPI-613. Conclusion: CPI-613 had an uncommon toxicological profile (induction of inflammation) in both animal species, which reflects its novel mechanism of action.

show abstract

Prevalence and relevance of contact dermatitis allergens: A meta-analysis of 15 years of published T.R.U.E. test data

Cited by 93 publications

References 35 publications

Prospective study of patch testing in patients with vulval pruritus

Prospective study of patch testing in patients with vulval pruritus

A Severe Reaction to Ni-Containing Orthodontic Appliances

Uncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel Mechanism

Contact Info

Product

Resources

About