Prevalence and resistance profile of &lt;i&gt;Escherichia coli&lt;/i&gt; and &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt; isolated from urinary tract infections in N'Djamena, Tchad

Yandai, Fissou Henry; Ndoutamia, Guelmbaye; Nadlaou, Bessimbaye; Barro, Nicolas

doi:10.4314/ijbcs.v13i4.13

Cited by 10 publications

(8 citation statements)

References 12 publications

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“…and S. aureus (Table 2). These results corroborate those of previous studies conducted in Africa [23][24][25]. Many virulence and tness factors confer advantages to uropathogenic E. coli (UPEC) and K. pneumoniae (UPKP) in the host urinary tract.…”

Section: Discussionsupporting

confidence: 91%

Epidemiology of Community Origin of major multidrug-resistant ESKAPE uropathogens in a paediatric population in South-East Gabon

Mouanga-Ndzime

Onanga

Longo-Pendy

et al. 2022

Preprint

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Background: Urinary tract infections (UTIs) in children are very common. They are often associated with a high risk of sepsis and death. In addition, antibiotic resistance of UTI pathogens isolated from children is steadily increasing, especially against commonly used antibiotics. The study’s main objective was to examine the epidemiology of community origin and antibiotic sensitivity of major ESKAPE uropathogens in paediatric UTIs in South-East Gabon. Methods:The study was conducted from January 2018 to December 2021 and involved 508 children aged 0-17 years. Identification of bacterial isolates was carried out using the Vitek-2 compact automated system and the antibiogram with the disk diffusion and microdilution methods according to the European Committee on Antimicrobial Susceptibility Testing recommendations. Results: The prevalence of UTIs was 59%. E. coli and K. pneumoniae were the main ESKAPE involved in UTIs followed by Enterococcus spp. and S.aureus. The multidrug-resistant (MDR) phenotype was the most common. DTR-E. coli, CRE-K. pneumoniae and MDR-K. pneumoniae were associated with pyelonephritis. MRSA UTIs were frequent in symptomatic children. ESC-E. coli and MRSA were associated with recurrent UTIs while VRE and ESC-E. coli were associated with empirical treatment failures. MDR-E. coli, ESC-E. coli, MDR-K. pneumoniae, ESC-K. pneumoniae, UDR-K. pneumoniae, CRE-K. pneumoniae and XDR-K. pneumoniae were associated with rural paediatric populations. Conclusion: This study describes the resistance phenotypes DTR, UDR and MAR index in Gabon. It showed a high prevalence of paediatric UTIs with high frequency of E. coli, K. pneumoniae, Enterococcus spp. and S. aureus with heterogeneous resistance profiles (MDR, XDR, DTR, ESC, CRE, MRSA and VRE).

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Section: Discussionsupporting

confidence: 91%

Epidemiology of Community Origin of major multidrug-resistant ESKAPE uropathogens in a paediatric population in South-East Gabon

Mouanga-Ndzime

Onanga

Longo-Pendy

et al. 2022

Preprint

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“…Only carbapenem (imipenem) was effective against all tested strains in the β-lactam class. The absence of resistance to this antibiotic was previously reported by Yandai et al [32] in Chad and Kotb et al [33] in Egypt.…”

Section: Disk Diffusion Susceptibility Testingsupporting

confidence: 63%

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

Benmoumou

Hamaidi-Chergui

Bouznada

et al. 2023

Advanced Research in Life Sciences

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Urinary tract infections (UTIs) are currently one of the most important medical practice visits. The spread of antibiotic-resistant bacteria in the community complicates the therapeutic management. The aim of this study is to investigate the bacteria associated with community acquired urinary tract infections (CA-UTIs) and the antibiotic resistance pattern of bacterial isolates during 2021 in Algiers, northern Algeria. A total of 548 urine samples from patients with CA-UTIs symptoms were analyzed. Pure bacterial isolates were identified using morphological and biochemical characteristics, and subjected to antibiogram evaluation using the disk diffusion method. A total 133 out of 548 patients (24.27%) had positive CA-UTIs, mainly affecting women (84.21%). A percentage of 87.22% of isolates were identified as Enterobacteriaceae, which were represented mostly by Escherichia coli (76 isolates), Klebsiella pneumoniae (13 isolates), and Proteus mirabilis (13 isolates). A number of 125 isolates (93.98%) were resistant to at least one antibiotic tested. The results showed the highest antibiotic resistance to ampicillin (92.24%) and amoxicillinclavulanic acid (91.37%), and revealed the most sensitivity to cefotaxime and nitrofurantoin (95.69%) and colistin (93.11%). The results of this study revealed high concerns about CA-UTIs caused by multidrug-resistant Enterobacteriaceae.

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“…Such prevalence is similar to 24.5% for E. coli and 18.4% for K. pneumoniae reported in an earlier study in Nigeria. 17 However, the prevalence of E. coli found in UTIs is significantly lower than those between 60% and 90% reported in Chad; 18 Madagascar; 19 Rwanda 20 and Morocco. 21 We found that urinary tract infections due to E. coli mainly affected women, which is in agreement with similar studies carried out in Cameroon 22 and Nigeria.…”

Section: Discussionmentioning

confidence: 85%

“…Similar resistance rates have been reported on an outpatient basis in West Africa, 26 Madagascar, 19 the Central African Republic 27 and Chad. 18 These high resistance rates could explain why aminopenicillins and carboxypenicillins are no longer recommended for the probabilistic treatment of UTIs. 28…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Community Origin Escherichia coli and Klebsiella pneumoniae Uropathogenic Strains Resistant to Antibiotics in Franceville, Gabon

Ndzime¹,

Onanga²,

Kassa³

et al. 2021

IDR

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Introduction Urinary tract infection is one of the major causes of consultation, microbiologic exploration, intensive use of antibiotics worldwide, and the second leading cause of clinical consultation in community practice. Many bacteria play a role in the urinary tract infections etiology, including Enterobacteriaceae such as Escherichia coli ( E. coli ) and Klebsiella spp. Objective The study’s main objective was to examine the epidemiology of E. coli and Klebsiella pneumoniae ( K. pneumoniae ) uropathogenic strains resistant to antibiotics in Franceville. Methodology The study was carried out between January 2018 and June 2019 in Franceville South-East Gabon. We examined a total of 1086 cytobacteriological urine samples. The identification of E. coli and K. pneumoniae strains was carried out using the Vitek-2 compact automated system and the antibiogram with the disk diffusion method according to the European Committee on Antimicrobial Susceptibility Testing recommendations. Results The prevalence of urinary tract infections was 29.2% (317/1086), of which 25.1% and 4.1% were mono-infections and co-infections, respectively. The prevalence of UTIs with E. coli was 28.7% (91/317) with a predominance of isolation in women. K. pneumoniae was responsible for 16.2% (61/317) of UTIs. E. coli and K. pneumoniae Uropathogenic strains showed resistance to beta-lactams, quinolones and cotrimoxazole, whereas Nitrofurantoin, Amikacin, Imipenem and Ertapenem were the most active antibiotics against E. coli and K. pneumoniae uropathogenic strains. Conclusion This study showed a high prevalence of urinary tract infections with a major implication of E.coli and K. pneumoniae strains. E. coli and K. pneumoniae presented high frequency of resistance to antibiotics, highlighting the need to adapt their use accordingly at the local level.

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Prevalence and resistance profile of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> isolated from urinary tract infections in N'Djamena, Tchad

Cited by 10 publications

References 12 publications

Epidemiology of Community Origin of major multidrug-resistant ESKAPE uropathogens in a paediatric population in South-East Gabon

Epidemiology of Community Origin of major multidrug-resistant ESKAPE uropathogens in a paediatric population in South-East Gabon

Antibiotic Resistance Pattern of Enterobacteriaceae Strains Isolated from Community Urinary Tract Infections in Algiers, Algeria

Epidemiology of Community Origin Escherichia coli and Klebsiella pneumoniae Uropathogenic Strains Resistant to Antibiotics in Franceville, Gabon

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