Prevalence and Symptom Pattern of Pathologic Esophageal Acid Reflux in Patients With Functional Dyspepsia Based on the Rome III Criteria

Xiao, Yinglian; Peng, Sui; Jin, Tao; Wang, Anjiang; Lin, Jin-kun; Hu, Pinjin; Chen, Minhu

doi:10.1038/ajg.2010.351

Cited by 86 publications

(64 citation statements)

References 11 publications

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“…18 In addition, epigastric pain or burning sensation may be associated with gastroesophageal reflux. 19,20 Therefore, gastric acid hypersecretion might result in EPS-related symptoms. These findings suggest that the extent or grade of atrophic gastritis can be involved in the generation of specific dyspeptic symptoms.…”

Section: Discussionmentioning

confidence: 99%

Association of the Extent of Atrophic Gastritis With Specific Dyspeptic Symptoms

Chung

Lee

Kim

et al. 2015

J Neurogastroenterol Motil

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Background/AimsIt remains unclear whether atrophic gastritis can affect dyspeptic symptoms. We aimed to investigate whether the extent of atrophic gastritis is associated with specific dyspeptic symptoms. MethodsConsecutive adults in a routine health-checkup program were enrolled in the study. The extent of atrophic gastritis was classified into 3 groups based on the Kimura-Takemoto criteria; the gastritis with no or little atrophy (group A: C0), the gastritis with atrophy mainly in the antrum (group B: C1 and C2), and the gastritis with atrophy in the large area of the corpus (group C: C3 and O). Upper gastrointestinal symptoms were categorized into "typical reflux symptoms," "epigastric pain syndrome (EPS)-related symptoms," and "postprandial distress syndrome (PDS)-related symptoms." ResultsA total of 1827 patients (1009 males, mean age 45.1 years) were included in the analysis. The subgroups of atrophic gastritis were as follows: group A (n = 1218, 66.7%), group B (n = 392, 21.4%), and group C (n = 217, 11.9%). Typical reflux, EPS-related, and PDS-related symptoms were present in 10.5%, 19.8%, and 16.2% of the subjects, respectively. PDS-related and EPS-related symptoms were significantly more prevalent in the group C of male patients and the group B of female patients, respectively, compared with other groups. PDS-related and EPS-related symptoms were independently associated with the group C in males (OR, 2.123; 95% CI, 1.090-4.136) and the group B in females (OR, 2.571; 95% CI, 1.319-5.025), respectively. ConclusionsThe extent of atrophic gastritis appears to affect the generation of specific dyspeptic symptoms in a gender-dependent manner. (J Neurogastroenterol Motil 2015;21:528-536)

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Section: Discussionmentioning

confidence: 99%

Association of the Extent of Atrophic Gastritis With Specific Dyspeptic Symptoms

Chung

Lee

Kim

et al. 2015

J Neurogastroenterol Motil

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“…There is a significant overlap in symptoms between GERD and FD, and studies have shown that many patients who are diagnosed with FD may have significant underlying pathological acid reflux into the distal esophagus. Tack et al [26] showed that acid reflux was present in 23% of patients diagnosed with FD according to the ROME II criteria, whilst Xiao et al [27] showed an even higher rate of 31.7% when using the ROME III criteria. Both studies have shown that FD patients with pathological acid reflux were more likely to have ‘ulcer-like' dyspepsia (Rome II classification) or EPS (Rome III classification).…”

Section: Epidemiological Changes Which May Be Contributing To Changesmentioning

confidence: 99%

The Influence of Cultural Habits on the Changing Pattern of Functional Dyspepsia

Yap¹,

Mahadeva²,

Goh³

2014

Dig Dis

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Dyspepsia is a common gastroenterological problem with an estimated global prevalence between 7 and 40%. Functional dyspepsia (FD) is a major economic burden to patients and healthcare systems and significantly affects patient quality of life. The ROME III definition of FD divides it into two subgroups, epigastric pain syndrome and postprandial distress syndrome, the former being more associated with reflux disease and the latter with gastric dysmotility. The global incidence and prevalence of FD continues to rise, but the reason for this is not clear. Rising global obesity and gastroesophageal reflux disease rates may be contributing to the rise in FD. Socioeconomic and cultural demographic changes such as changing dietary habits and rapid urbanization, particularly in the developing countries, are likely to be influencing the course of FD and the way it presents.

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“…One study [18] has shown that 37% of patients fulfilling the criteria for EPS also had esophageal acid reflux as determined by pH monitoring despite a normal endoscopy [18]. While further validation of the Rome III criteria for FD is needed, it will be the unraveling of the pathophysiology of this condition which will see a shift towards a more objective classification of FD.…”

Section: Epigastric Pain Syndromementioning

confidence: 99%

Women and Functional Dyspepsia

Napthali

Koloski

Walker

et al. 2016

Womens Health (Lond Engl)

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Functional dyspepsia is relatively common yet poorly understood. The best accepted diagnostic criteria are the Rome III criteria. The epidemiology, healthcare seeking rates, impact and pathophysiology are reviewed with a focus on women. Treatment is limited with no clearly established regimen currently recommended. Duodenal eosinophilia may be found in a subset. Proton pump inhibitors and prokinetic agents represent the standard therapeutic regimen after Helicobacter pylori infection has been eliminated. Some novel agents such as the prokinetic acotiamide appear promising; however, the need for a safe and efficacious treatment remains largely unmet. This review also describes the currently available management options for functional dyspepsia.

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Prevalence and Symptom Pattern of Pathologic Esophageal Acid Reflux in Patients With Functional Dyspepsia Based on the Rome III Criteria

Abstract: PEAR is present in almost one third of FD patients; the prevalence is ∼50% in those with epigastric burning. The "PPI test" has a limited value in distinguishing the FD patients with and those without PEAR.

Cited by 86 publications

References 11 publications

Association of the Extent of Atrophic Gastritis With Specific Dyspeptic Symptoms

Association of the Extent of Atrophic Gastritis With Specific Dyspeptic Symptoms

The Influence of Cultural Habits on the Changing Pattern of Functional Dyspepsia

Women and Functional Dyspepsia

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