Prevalence, Awareness, and Risk Factors of Primary Open-Angle Glaucoma

Kim, Ko Eun; Kim, Moon Jung; Park, Ki Ho; Jeoung, Jin Wook; Kim, Seok Hwan; Kim, Chan Yun; Kang, Se Woong

doi:10.1016/j.ophtha.2015.11.004

Cited by 112 publications

(95 citation statements)

References 56 publications

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“…Our results are consistent with the notion that structural and functional measurements may each provide unique information for glaucoma [36–39]. Results from large clinical investigations [40–42] have identified older age as an independent risk factor for the development of glaucoma. For the present study cohort, older age was significantly associated with the development of glaucomatous VF defects on FDT, but not on SAP.…”

Section: Discussionsupporting

confidence: 91%

“…Our findings affirm the usefulness of FDT in detecting the development of glaucomatous VF defects in suspect eyes. Higher baseline intraocular pressure (IOP) has been considered as another risk factor for the development of glaucoma [40–42]. Since a portion of our participants had begun IOP-lowering treatments at baseline based on the discretion of the attending ophthalmologists, we didn’t include baseline IOP for the analysis of risk factors.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes

Wang

Racette

2017

PLoS ONE

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BackgroundPerimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry in monitoring the development of visual field (VF) defects in glaucoma suspect eyes.MethodsLongitudinal data of paired SAP and FDT from 221 eyes of 155 glaucoma suspects enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included. All eyes had glaucomatous optic neuropathy or ocular hypertension, but normal SAP and FDT results at baseline. The development of glaucomatous VF defects was defined as the presence of a cluster of ≥ 3 (less conservative) or ≥ 4 (more conservative) locations confirmed on ≥ 2 additional consecutive tests. Risk factors for the development of VF defects were analyzed by COX proportional hazard models. After conversion into common logarithmic units, the rates of change of global VF indices were fitted with linear mixed models.ResultsFDT detected more eyes that developed VF defects than SAP using the less conservative criterion, and no significant difference was observed using the more conservative criterion. For those eyes detected by both SAP and FDT, FDT detected the development of VF defects either earlier than SAP or simultaneously in most cases. Baseline structural measurements were not significantly associated with an increased risk for the development of glaucomatous VF defects on either SAP or FDT. Older age was significantly associated with the development of VF defects on FDT but not on SAP. Both SAP and FDT detected a progressing worsening trend of pattern standard deviation over time with a similar rate of change between these test types.ConclusionsMatrix FDT would be useful to monitor the onset of VF defects in glaucoma suspects and may outperform SAP in the early stage of glaucomatous VF damage.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes

Wang

Racette

2017

PLoS ONE

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“…Exfoliative glaucoma (EXG) is characterized by high IOP and worse 24-h IOP, and it represents the most common type of secondary OAG. Various risk factors have been investigated to evaluate the associations with the development and progression of glaucoma, including increased age, gender, high IOP, and genetic variants [3,4]. However, the precise mechanisms involved in glaucoma are yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Serum Vitamin B6, Vitamin B12, and Vitamin D Levels with Different Types of Glaucoma: A Systematic Review and Meta-Analysis

Shao

et al. 2017

Nutrients

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Although vitamins play a major role in health, and their deficiency may be linked to symptoms of optic-nerve dysfunction, the association between serum vitamin levels and glaucoma in humans remains controversial. In this study, articles in the PubMed, Web of Science, and EMBASE databases were searched up to 25March 2017. Nine studies on primary open-angle glaucoma (POAG), four studies on normal tension glaucoma (NTG), and six studies on exfoliative glaucoma (EXG) were retrieved. The combined results showed no differences in the levels of serum vitamin B6 between POAG (p = 0.406) and EXG (p = 0.139) patients and controls. The weighted mean differences (WMDs) with 95% confidence intervals (CIs) were 2.792 ng/mL (−3.793 to 9.377) and 1.342 ng/mL (−3.120 to 0.436), respectively. There was no difference between POAG (p = 0.952), NTG (p = 0.757), or EXG (p = 0.064) patients and controls in terms of serum vitamin B12. The WMDs with 95% CIs were 0.933 pg/mL (−31.116 to 29.249), 6.652 pg/mL (−35.473 to 48.777), and 49.946 pg/mL (−102.892 to 3.001), respectively. The serum vitamin D levels exhibited no differences (p = 0.064) between POAG patients and controls; the WMD with 95% CI was 2.488 ng/mL (−5.120 to 0.145). In conclusion, there was no association found between serum vitamin B6, vitamin B12, or vitamin D levels and the different types of glaucoma.

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“…28 Another Korean population-based study estimated an OAG prevalence of 4.7% among those aged 40 years and older, and of 4.5% among those with an IOP ≤ 21 mmHg. 30 Certainly, the high NTG prevalence in Korean OAG populations can help to clarify the associations between RVO and OAG found in the present study.…”

Section: Discussionmentioning

confidence: 56%

“…Based on a previous Korean population-based study, Kim et al 30 reported for the 40 years and older demographic, an OAG prevalence of 4.7% and a disease awareness of 8.0%. Among them, 79.4% had been receiving glaucoma treatment, or about 0.30% of the Korean population of that age.…”

Section: Discussionmentioning

confidence: 99%

Incidence of retinal vein occlusion in open‐angle glaucoma: a nationwide, population‐based study using the Korean Health Insurance Review and Assessment Database

Jeoung

Kim

et al. 2018

Clinical Exper Ophthalmology

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Prevalence, Awareness, and Risk Factors of Primary Open-Angle Glaucoma

Cited by 112 publications

References 56 publications

Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes

Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes

Lack of Association between Serum Vitamin B6, Vitamin B12, and Vitamin D Levels with Different Types of Glaucoma: A Systematic Review and Meta-Analysis

Incidence of retinal vein occlusion in open‐angle glaucoma: a nationwide, population‐based study using the Korean Health Insurance Review and Assessment Database

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