Prevalence of ABO blood groups in patients with haematological malignancies: a retrospective study

Abstract

Background: The pattern and distribution of Haematological malignancies vary depending on age, sex and geographical location. Studies on the association between Haematological cancers and ABO blood types have been largely conflicting. The objective of our study was to determine the distribution of ABO blood groups among patients with Haematological malignancies and to correlate with age and gender. Materials and Methods: This was a chart based observational descriptive study involving the review of records of 85 patients with various Haematological malignancies in Father Muller Medical College Hospital for a period of two years from July 2017- June 2019. Age, gender, malignant condition, ABO and Rh blood group were collected for each case. Data was analyzed statistically by frequency and percentage. Results: The peak age incidence for various Haematological malignancies was in the fifth and sixth decades of life with a mean age of 47.The male to female sex ratio was almost 1:1. Majority of the patients were of the O blood group and an association of O blood group with various hematological malignancies with male preponderance was noted. Altogether, Leukemias were the most common Haematological malignancy observed in this study. Conclusion: The distribution, age and sex ratio of Haematological malignancies in our study was comparable to those reported by other authors with Acute Myeloid Leukemia (AML) being the most common Haematological malignancy in our environment. There was no significant association between Haematological cancers and ABO blood type of the patients, but probably individuals with O Rh positive blood group are more prone to

Novel evidence that the ABO blood group shapes erythropoiesis and results in higher hematocrit for blood group B carriers

“…In addition to the physiological changes, the association between ABO BG antigens expression and erythropoiesis is known for carcinomas and hematological malignancies [ 32 , 56 – 58 ]. The association of reduction or complete deletion of A/B antigen expression with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and myeloproliferative disorders including chronic myeloid leukemia is well documented [ 59 ].…”

“…Furthermore, the loss of A, B or H antigens from the surface of RBCs can be seen in hematological malignancies. Thus, the loss of ABO BG antigens expression in an RBC population derived from a malignant HSC clone could be an indicator of genetic changes during oncogenesis on the stem/progenitor cell level [ 32 ].…”

Association of long non-coding RNAs and ABO blood groups with acute lymphoblastic leukemia in Egyptian children

“…As for exploring ABO blood groups distribution and their possible association with ALL etiopathology, the majority of the patients were of the A-blood type while the AB blood group was the least common. In congruence, previous studies showed that the AB-blood group type in hematologic malignancies was the least common [ 83 , 84 ]. Other study showed that the most common blood group of leukemia patients was B [ 25 ].…”