Prevalence of Congenital Anomalies: A Community-Based Study in the Northwest of Iran

Abdolahi, Hossein Mashhadi; Maher, Mohammad Hassan Kargar; Afsharnia, Farzaneh; Dastgiri, Saeed

doi:10.1155/2014/920940

Cited by 27 publications

(22 citation statements)

References 4 publications

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“…The prevalence of birth defects in the present study is 0.58%, which is comparable to other studies in Nepal, Iraq and Iran which reported an incidence of 0.69% and 0.36% [18][19][20]. Our study showed that Musculoskeletal System to be most commonly affected, presenting as cleft lip, cleft palate and club feet which is in line with studies reported from Egypt and India [21,22].…”

Section: Discussionsupporting

confidence: 91%

Burden and consequence of birth defects in Nepal-evidence from prospective observational study

Paudel

Sunny²,

Gurung³

et al. 2020

Preprint

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Background-Every year an estimated 7.9 million babies are born with birth defects. Of these, more than 3 million die and a further 3.2 million suffer from a disability. In order to address this, countries require data to enable better resource allocation for prevention, management and rehabilitation of babies born with birth defects. This paper contributes to this evidence base, assessing the prevalence of birth defects, associated risk factors and health consequences in Nepal. Method-This is a prospective observational study conducted in 12 hospitals in Nepal for 18 months. All the women who delivered in the hospitals during the study period were enrolled. Independent researchers collected social and demographic data using semi-structured questionnaires at the time of discharge. Clinical events and birth outcome information were extracted from clinical case notes. Data were analysed to determine the prevalence and type of birth defect. Logistic regression was performed to assess risk factors and health outcomes of babies born with a birth defect. Results-Among the total 87,242 livebirths, the prevalence of birth defects was found to be 5.8 per 1000 live births. The most common birth defects observed were anencephaly (3.95%), cleft lip (2.77%), cleft lip and palate (6.13%), clubfeet (3.95%), eye abnormalities (3.95%) and meningomyelocele (3.36%). The odds of having a baby with a birth defect was higher for mothers younger than 20 years (adjusted Odds ratio (aOR) 1.64; 95% CI, 1.18-2.28) and those from disadvantaged ethnicity (aOR 1.78; 95% CI, 1.46-2.18). The odds of birth asphyxia was almost double for babies with birth defect (aOR 1.88; 95% CI, 1.41-2.51) when compared to babies without a birth defect. The odds of neonatal infection was nearly double for babies with birth defect (aOR 1.82; 95% CI, 1.12-2.96) compared to babies without a defect. Babies with a birth defect had three-fold risk of pre-discharge mortality (aOR 3.00; 95% CI, 1.93-4.69). Conclusion- Babies with birth defect have a higher risk of birth asphyxia, neonatal infection and pre-discharge mortality at birth. A portion of birth defect could have been prevented through micro-nutrient supplementation, a portion can be managed through surgery and rehabilitation. Funding-Swedish Research Council (VR)

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Section: Discussionsupporting

confidence: 91%

Burden and consequence of birth defects in Nepal-evidence from prospective observational study

Paudel

Sunny²,

Gurung³

et al. 2020

Preprint

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“…A study from Iran done about the same period with the current study (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012) however reported a similar incidence (11.2/1000 births). 13 There was an increase in the yearly incidence during the study period with the incidence for the year 2014 being over 5 times that of 2007. The reason for this may be the problems of urbanisation such as exposure to environmental pollution and modernisation including exposure to radiation from electronic gadget such as mobile phones and computers with its attendant effects on the populace.…”

Section: Discussionmentioning

confidence: 89%

An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria

Fajolu¹,

Ezenwa²,

Akintan³

et al. 2016

Nig. J. Paed.

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“…[8][9][10] Differently, other studies report higher frequency of CAs of the cardiovascular system. 5,[11][12][13] On the other hand, the higher frequency of CNS has been reported in several studies in Iran, 14 Japan, 15 Pakistan, 16,17 China, 18 Nigeria, 19 Tanzania, 20 and India. [8][9][10] The etiology of CNS anomalies is multifactor and involves complex interactions between genetic and environmental factors, constituting one of the most common congenital defects.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

Moraes

Melo

Amaral

2020

Rev Bras Ginecol Obstet

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Objective To evaluate the frequency of structural congenital anomalies (CAs) in the midwest of Brazil and its association with maternal risk factors. Methods This was a prospective, observational, case-control study based on a hospital population. Pregnant women attended at a fetal medicine service in Brazil were analyzed in the period from October 2014 to February 2016.A total of 357 pregnant women were included, 223 of whom had fetuses with structural anomalies (group case), and 134 of whom had structurally normal fetuses (control group). The clinical history was made previous to prenatal consultation, and the diagnosis of the structural CA was performed through ultrasound. Results A frequency of 64.27% (n = 223) of pregnant women with fetuses with structural anomalies was observed. The most frequent structural CAs were those of the central nervous system (30.94%), followed by anomalies of the genitourinary system (23.80%), and, finally, by multiple CAs (16.60%). The background of previous children with CAs (odds ratio [OR]: 3.85; p = 0.022), family history (OR: 6.03; p = < 0.001), and consanguinity between the progenitors (OR: 4.43; p = 0.034) influenced the occurrence of structural CA. Conclusion The most frequent CAs are those of the central nervous system, followed by those of the genitourinary system, and then multiple anomalies. The maternal risk factors that may have influenced the occurrence of structural CA were previous children with CA, family history, and consanguinity among the parents.

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Prevalence of Congenital Anomalies: A Community-Based Study in the Northwest of Iran

Cited by 27 publications

References 4 publications

Burden and consequence of birth defects in Nepal-evidence from prospective observational study

Burden and consequence of birth defects in Nepal-evidence from prospective observational study

An 8-year review of major congenital abnormalities in a tertiary hospital in Lagos, Nigeria

Frequency of Congenital Anomalies in the Brazilian Midwest and the Association with Maternal Risk Factors: Case-control Study

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