Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer

Yamashita, Kaoru; Ohara, Masaru; Kojima, Takanori; Nishimura, Rumi; Ogawa, Tetsuji; Hino, Takamune; Okada, Morihiko; Toratani, Shigeaki; Kamata, Nobuyuki; Sugai, Motoyuki; Sugiyama, Masaru

doi:10.2334/josnusd.55.145

Cited by 25 publications

(21 citation statements)

References 29 publications

(33 reference statements)

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“…In individuals presenting periodontal diseases and/or immunological impairment, these opportunistic species may be found in M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 11 higher proportions than in immunocompetent and/or periodontally healthy patients. For instance, C. albicans, S. aureus, and P. aeruginosa were detected in the oral cavity of 68.4%, 43.7%, and 57.1% of elderly adults, respectively, after primary treatment of oral cancer [38]. Our group reported high prevalence rates for staphylococci (81.5%), pseudomonads (83%) and Acinetobacter spp.…”

Section: Discussionmentioning

confidence: 78%

Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance

Colombo

Magalhães

Hartenbach

et al. 2016

Microbial Pathogenesis

241

154

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The ecological diversity of the periodontal microenvironment may provide suitable conditions for the colonization of species not usually considered members of the oral microbiota. In this investigation, we aimed to determine the prevalence and levels of pathogenic species of medical relevance in the microbiota of individuals with distinct periodontal clinical status. Subgingival biofilm was obtained from patients with periodontal health (H, n = 81), gingivitis (G, n = 55), generalized aggressive (AgP, n = 36) or chronic periodontitis (CP, n = 98), and analyzed for 39 microbial taxa using a checkerboard DNA-DNA hybridization technique. Microbial differences among groups, as well as associations between clinical and microbiological parameters were sought by non-parametric and univariate correlation tests. Neisseria spp., Peptostreptococus anaerobius, Candida albicans, enterobacteria, Pseudomonas aeruginosa, Eubacterium saphenum, Clostridium difficile and Olsenella uli were detected in high mean prevalence and counts in the subgingival microbiota of the study population. Species that were more related to periodontal inflammation and tissue destruction at the patient and site levels included enterobacteria, C. albicans, Neisseria spp., P. aeruginosa, O. uli, Hafnia alvei, Serratia marcescens and Filifactor alocis (p < 0.05). In contrast, Fusobacterium necrophorum, Lactobacillus acidophilus, Staphylococcus aureus and Streptococcus pneumoniae were associated with periodontal health (p < 0.05). Pathogenic species of medical importance may be detected in high prevalence and levels in the periodontal microbiota. Regardless of their role in periodontal health or disease, the periodontal biofilm may be a source for dissemination and development of systemic infections by these pathogenic microorganisms.

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Section: Discussionmentioning

confidence: 78%

Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance

Colombo

Magalhães

Hartenbach

et al. 2016

Microbial Pathogenesis

241

154

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“…Both S. aureus and S. epidermidis are found in patients with dental infection (particularly abscess); however, the possible presence of S. aureus is especially important in dental care due to its increased resistance. Earlier literature states that S. aureus amplified significantly after surgical induction of hyposalivation [14].…”

Section: Resultsmentioning

confidence: 99%

Occurrence of vancomycin-resistant Staphylococcus aureus in the oral cavity of patients with dental caries

Vellappally

Kheraif

Ramakrishnaiah

et al. 2017

AMicr

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Oral streptococci are the major group of microbes isolated from oral microflora. They represent frequent pathogens of infective endocarditis (IE), and it is assumed that in most of the cases oral streptococci are acquired via mucosa layer of oral cavity. Staphylococcus aureus is also frequently isolated from IE as it accounts for 20%-30% of all cases. Vancomycin has been the most reliable therapeutic agent against infections caused by methicillin-resistant S. aureus (MRSA). The main objective of this study was to examine the occurrence of S. aureus species in dental caries specimens. Antimicrobial susceptibility testing of S. aureus to four antibiotics namely vancomycin, linezolid, teicoplanin, and daptomycin was performed. Detection of vancomycin resistance was conducted using polymerase chain reaction. Among the tested 150 strains, 98 were MRSA and of that 54 were vancomycin sensitive and 27 were resistant. All 98 MRSA strains were positive for mecA and 36 yielded pvl, whereas 13 carried vanA and only 2 were positive for vanB. Majority of the isolates showed sensitivity toward daptomycin and linezolid. Strains of S. aureus exhibiting decreased susceptibility to different antibiotics like vancomycin, daptomycin, and linezolid severely compromise the therapeutic alternatives and require a considerable amount of time, public awareness, and integrative health-care strategies to prevent the emergence of resistance to these compounds.

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“…The most represented opportunistic microorganisms include Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans [2,3]. Unfortunately, due to the overuse and misuse of antibiotics, most of these organisms become drug resistant, leading to difficulties in curing related infectious diseases and thus reducing therapeutic options [3,4].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

Assaf

Amro

Mashallah

et al. 2016

J Infect Dev Ctries

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Introduction: Methanolic extracts of six plants (Arbutus andrachne, Chrysanthemum coronarium, Inula viscosa, Origanum syriacum, Punica granatum, and Rosmarinus officinalis) used in traditional medicine for the treatment of bacterial and fungal infections were evaluated. The present study was conducted to evaluate the antimicrobial and anti-inflammatory activity of some medicinal plants in lowering the risk of opportunistic infections of the oral cavity caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Extracts were evaluated separately and in a mixture. Methodology: The methanolic plant extracts were tested against three opportunistic microorganisms by determining the minimum inhibitory concentration (MIC). They were also evaluated for their ability to suppress the release of the pro-inflammatory cytokine IL-6 while not suppressing the release of the anti-inflammatory cytokine IL-10 from peripheral blood mononuclear cells using ELISA. Results: All extracts showed both antimicrobial and anti-inflammatory activities. However, O. syriacum exhibited the highest antimicrobial activity for the three microorganisms among all of the tested extracts (MIC S. aureus: 1 mg/mL; P. aeruginosa: 2 mg/mL; and C. albicans: 1 mg/mL). The extracts inhibited the expression of the pro-inflammatory cytokine IL-6 with apparent dose-dependent responses while they attenuated the secretion of the anti-inflammatory cytokine IL-10. The mixture of O. syriacum and R. officinalis showed an anti-inflammatory effect, with a synergistic antimicrobial effect. Conclusion: These findings support the idea that a diet rich in plants and herbs may contribute to the reduction of inflammation and microbial growth and may also be preventive against various infections, including those related to the oral cavity.

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Prevalence of drug-resistant opportunistic microorganisms in oral cavity after treatment for oral cancer

Cited by 25 publications

References 29 publications

Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance

Periodontal-disease-associated biofilm: A reservoir for pathogens of medical importance

Occurrence of vancomycin-resistant Staphylococcus aureus in the oral cavity of patients with dental caries

Antimicrobial and anti-inflammatory potential therapy for opportunistic microorganisms

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