Prevalence of E. Coli in Urinary Tract Infection of Children Aged 1-15 Years in A Medical College of Eastern Nepal

Giri, Arun; Kafle, Raju; Singh, Ganesh Kumar; Niraula, Niraj

doi:10.31729/jnma.4796

Cited by 9 publications

(8 citation statements)

References 8 publications

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“…Thus, the prevalence in our study was correlated with that of developing countries. In our study, women were more significantly affected than men, and this finding was observed in other studies as well [ 2 , 12 ]. The close proximity of the urethra to the anus is the major predisposing factor, which is responsible for the frequent contamination of urethral passage by fecal flora.…”

Section: Discussionsupporting

confidence: 91%

Retrospective Analysis of Urinary Tract Infection in the Pediatric Population at a Tertiary Care Centre

Perween¹,

Rai²,

Nandwani³

et al. 2022

Cureus

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Background: Urinary tract infection (UTI) is among the most common infections occurring during childhood. It is caused by both gram-negative and gram-positive bacteria and Escherichia coli is the most common causative agent. Methods: Data of all pediatric patients in the age group of 6 months to 18 years with urinary tract infection were taken for analysis. Urine samples were collected and cultured on the cystine lactose electrolyte-deficient medium. The presence of bacteria was identified using biochemicals, and the antimicrobial test was performed using the Kirby-Bauer test or the VITEK 2 compact system (bioMérieux, Inc., France). Results: The prevalence of UTI was 23.5%. In total, 614 specimens tested positive with significant bacteriuria. The male-to-female ratio was 1:2.3. Approximately 54% patients presented with urinary symptoms alone. Culture positivity was significantly associated with pyuria (p < 0.0001). E. coli (334/614) was the most common isolate, followed by Enterococcus spp. (92/614). Colistin, polymyxin B, fosfomycin, nitrofurantoin, netilmicin, and amikacin were extremely good acting antimicrobials. Meanwhile, ampicillin, cefotaxime, ceftriaxone, and norfloxacin were highly resistant to gram-negative bacteria. Multidrug-resistant bacteria and extended-spectrum beta-lactamase-producing bacteria were found in 47% and 44.1% of cases, respectively. Vancomycin, linezolid, teicoplanin, and nitrofurantoin were highly effective against gram-positive bacteria. Furthermore, norfloxacin, trimethoprim/sulfamethoxazole, ciprofloxacin, and tetracycline were highly resistant to gram-positive bacteria. Of the 92, 42 Enterococcus spp. were resistant to high-dose gentamicin. Conclusion: Nitrofurantoin and amikacin can be used as empirical therapy for gram-negative and gram-positive bacteria. Because resistance to various commonly used antibiotics is found to be increasing, treatment must be guided by antibiotic susceptibility reports.

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Section: Discussionsupporting

confidence: 91%

Retrospective Analysis of Urinary Tract Infection in the Pediatric Population at a Tertiary Care Centre

Perween¹,

Rai²,

Nandwani³

et al. 2022

Cureus

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“…This is comparable to studies by Ullah A and Seifu WD. (6,14) E coli was the commonest bacteria responsible for urinary tract infection in our study comparable to many other studies (12,15,16,17,18,19) followed by Candida species.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of various pathogens isolated from urine cultures causing urinary tract infections in Bakhtawar Amin Trust Hospital, Multan

Pasha¹,

Kashif²,

Sajid³

et al. 2021

PJMHS

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Objective: This study is conducted to ascertain the microbial agents along with their prevalence leading to urinary tract infections in patients admitted in Bakhtawar Amin Hospital, Multan with manifestations of urinary tract infections. Design: Descriptive observational study Place and duration of study: Department of Microbiology Bakhtawar Amin Medical & Dental College & Hospital, Multan from January 2021 to July 2021. Material and Methods: A total of 220 positive urine cultures were analyzed in this study extended for six months. All the appropriate details like age, gender, major presenting complaints, history of catheterization etc were noted. All the isolated urinary pathogens were recorded along with their frequency and percentages. Results: Out of these 220 patients with positive urine cultures, majority (63.6%) were male. Gram negative bacteria (E. Coli) constitute the major bulk of urinary pathogens followed by Candida. Conclusion: Urinary tract infections were commonly seen in men in our region. E. Coli was the most frequently encountered bacteria. A large number of Candida species were segregated in immunocompromised critically ill ICU admitted patients. Keywords: Urinary tract infection, culture, pathogens, E.Coli, Candida.

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“…Urinary tract infections are common in children [ 1 – 3 ]. Early diagnosis and treatment are necessary for the prevention of complications [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Epidemiology Characteristics and Antibiotic Resistance Associated with Urinary Tract Infections Caused by E. coli

Nguyen

Tran

et al. 2022

International Journal of Nephrology

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Introduction. In individuals with urinary tract infections, Escherichia coli (E. coli) is an ubiquitous causative agent and antibiotic resistance is on the rise throughout the world. Therefore, early diagnosis and appropriate choice of antimicrobials are essential. The purpose of our study is to describe some of the clinical and epidemiological characteristics and the laboratory test results of children treated in our hospital for urinary tract infections caused by E. coli. Methods. The study included 128 patients from 2 months to 15 years of age with urinary tract infections caused by E. coli and treated at the Haiphong Children’s Hospital during the periods of 2011–2013 and 2018–2020. Results. During the two study periods, 57 and 71 cases, respectively, were included. The most common clinical symptom was fever in 40 and 46 cases, respectively. The proportion of E. coli’s resistance to ampicillin increased from 85.3% in 2011–2013 to 97.1% in 2018–2020. In 2011–2013, 70.5% of E. coli isolates were resistant to cotrimoxazole, which increased to 81.4% during 2018–2020. During both periods, E. coli was highly sensitive to amikacin, at 87% and 95.5%, respectively. In 2018–2020, carbapenems (meropenem and imipenem) and piperacillin were also effective against E. coli. Conclusion. Our study revealed that high fever was the most prevalent clinical characteristic in urinary tract infections caused by E. coli in children and E. coli was mostly resistant to ampicillin, nalidixic acid, and cotrimoxazole but was highly sensitive to ciprofloxacin, amikacin, piperacillin, meropenem, and imipenem.

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Prevalence of E. Coli in Urinary Tract Infection of Children Aged 1-15 Years in A Medical College of Eastern Nepal

Cited by 9 publications

References 8 publications

Retrospective Analysis of Urinary Tract Infection in the Pediatric Population at a Tertiary Care Centre

Retrospective Analysis of Urinary Tract Infection in the Pediatric Population at a Tertiary Care Centre

Prevalence of various pathogens isolated from urine cultures causing urinary tract infections in Bakhtawar Amin Trust Hospital, Multan

Clinical Epidemiology Characteristics and Antibiotic Resistance Associated with Urinary Tract Infections Caused by E. coli

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