Prevalence of endometrial cancer or atypical hyperplasia diagnosed incidentally in infertility clinic

Tohma, Yusuf Aytaç; Zeyneloglu, Hulusi Bulent; Aslan, Öner Deniz; Haberal, Asuman Nihan; Önalan, Göğşen; Ayhan, Ali

doi:10.1016/j.ajog.2018.08.008

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…This series is limited by its small sample size and homogeneous population in a country with a low baseline prevalence of AH and/or EC. Likewise, Tohma et al (9) investigated the prevalence of AH and/or EC in women seen for an infertility evaluation in Turkey. In their study, 5,560 patients underwent endometrial biopsy or hysteroscopy based on symptoms or ultrasound findings, and 10 (0.18%) were diagnosed with EC and 17 (0.3%) were diagnosed with AH.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for atypical hyperplasia and endometrial cancer in the infertility population: a case-control study

Kahn¹,

Buckingham²,

Koelper³

et al. 2021

F&S Reports

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Objective: To estimate the incidence and identify risk factors for atypical endometrial hyperplasia (AH) and endometrial cancer (EC) in American women undergoing infertility evaluation. Design: Case-control study. Setting: Academic reproductive endocrinology and infertility practice. Patient(s): Female patients (18-50 years) seeking infertility evaluation from January 1, 2009 to December 1, 2018. Patients with known genetic predisposition to cancer or prior cancer diagnosis were excluded. Cases were defined as patients diagnosed with AH or EC during infertility workup (n ¼ 22). Controls without AH or EC were randomly selected in a 10:1 ratio (n ¼ 220) from all women undergoing infertility evaluation in the same year. Intervention(s): None. Main Outcome Measure(s): Incidence of AH or EC and odds of AH or EC accounting for age, race, body mass index (BMI), and ovulatory dysfunction. Result(s): Twenty-two cases of AH or EC were identified among 11,569 women undergoing infertility evaluation (incidence 2 per 1,000 women, 95% confidence interval [CI] 1.2-2.9 per 1,000). Of these women, 68% had a BMI R30 kg/m 2 compared with 25% of controls. In multivariable analyses, women with a BMI R30 kg/m 2 were 5.9 times more likely to be diagnosed with AH or EC (adjusted odds ratio 5.9, 95% CI 2.0-17.2). Women with ovulatory dysfunction were 3.4 times more likely to be diagnosed with AH or EC (adjusted odds ratio 3.4, 95% CI 1.1-10.1). Conclusion(s): The incidence of AH and EC in a population of women undergoing infertility evaluation is 10 times that in the general population of premenopausal women. Obesity is the strongest independent risk factor for AH and EC in women with infertility.

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Section: Discussionmentioning

confidence: 99%

Risk factors for atypical hyperplasia and endometrial cancer in the infertility population: a case-control study

Kahn¹,

Buckingham²,

Koelper³

et al. 2021

F&S Reports

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“…In the USA, approximately 110,070 new cases of endometrial cancer (EC) were diagnosed in 2018, and it is considered the fourth most common type of cancer after breast, lung and colorectal carcinoma ( Lortet-Tieulent et al, 2018 ; Siegel et al, 2021 ). Although approximately 90% of EC cases are diagnosed in women aged 50–55 years, approximately 21% of affected women receive an EC diagnosis before menopause ( Tohma et al, 2018 ). EC is the most common gynecologic malignancy, and various risk factors, such as excessive exposure of the endometrium to estrogen, early menarche, late menopause, tamoxifen therapy, nulliparity, infertility and polycystic ovary syndrome, have been associated with the onset of EC.…”

Section: Introductionmentioning

confidence: 99%

Integrated Transcriptome and Multiple Activated Pathways in Endometrial Cancer

Jin

Jiang

et al. 2021

Front. Genet.

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Because the incidence of endometrial cancer is notably increasing worldwide, it has become the leading gynecologic cancer in the United States. Standard treatment results in the loss of reproductive function in women of childbearing age. Furthermore, advanced cancer stages are associated with poor overall survival. The aim of this study was to explore the abnormal expression profile of genes during the development of endometrial cancer, which is essential to provide a better understanding of the mechanisms involved. Five pairs of endometrial cancer tissues and normal endometrial tissues were subjected to next-generation transcriptome sequencing technology. Quantitative real-time PCR (RT-qPCR) was performed to validate the expression profile of key differentially expressed genes (2.0-fold change, adj. p < 0.05) (DEGs) identified in the RNA-seq result. GO and KEGG pathways were used for bioinformatic analyses. The transcriptomic sequencing results showed 1153 DEGs, including 673 upregulated and 480 downregulated genes, in the EC specimens. Decreased expression of ID1, IGF1, GDF7, SMAD9, TGF-beta and WNT4, as well as GDF5, INHBA and ERBB4 overexpression, were confirmed in EC using RT-qPCR. Additionally, EC tissue exhibited marked enrichment in genes promoting cellular adhesion, proliferation, migration and plasma membrane. KEGG analysis revealed changes in various pathways, such as the TGF-beta, PI3K-Akt, Wnt, and estrogen pathways. Our data describe the molecular events involved in the pathogenesis of EC, which may be potential diagnostic markers and targets of therapeutic interventions.

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Introduction of Female Reproductive Processes and Reproductive Diseases

Zhang

Yan

2021

Environment and Female Reproductive Health

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Prevalence of endometrial cancer or atypical hyperplasia diagnosed incidentally in infertility clinic

Cited by 5 publications

References 7 publications

Risk factors for atypical hyperplasia and endometrial cancer in the infertility population: a case-control study

Risk factors for atypical hyperplasia and endometrial cancer in the infertility population: a case-control study

Integrated Transcriptome and Multiple Activated Pathways in Endometrial Cancer

Introduction of Female Reproductive Processes and Reproductive Diseases

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