Prevalence of Helicobacter pylori in Patients With Dyspepsia

Abstract

Background:The prevalence rate of gastric infections caused by Helicobacter pylori is different in between as well as within various countries, including Iran.Objectives:This study was aimed to evaluate the prevalence of H. pylori in Iranian adult patients with dyspepsia.Patients and Methods:A total of 548 patients with dyspepsia referred to Namazi Hospital, a referral center for gastrointestinal diseases in Shiraz, south of Iran, were evaluated in a cross-sectional study. The diagnosis of dyspepsia was based on clinical findings. Upper gastrointestinal endoscopy was performed for all the patients and two antral biopsies were taken from all the included ones. The patients were categorized based on the endoscopic findings, to four groups:normal,abnormal nonulcerative,ulcerative, andcombination of 2 and 3.Two positive test results (Gram staining, rapid urease test, and culture) was considered as a positive-definite H. pylori infection for each patient.Results:From the 548 included patients (238 males and 310 females), H. pylori was detected in 170 (31.2%). The mean age was 40.38 ± 15.39 years old. H. pylori infection was detected in 26.1% of male and 34.8% of female patients and its prevalence increased with age. Eighty three (48.8%) patients were positive for H. pylori infection, of which, 12.4% had normal and 36.4% had abnormal nonulcerative endoscopic findings; 17.1% of patients were ulcerative and 34.1% had ulcer with or without concurrent abnormality.Conclusions:Findings from this study showed a lower prevalence of H. pylori infection than other studies and its prevalence increased with age. There was no association between sex and infection. The most common endoscopic abnormality in H. pylori-positive patients was ulcerative lesion.

Helicobacter pylori Infection Rates in Patients Undergoing Endoscopy in the Interior of Borneo

“…Females in this study were 1.54 times more likely to have H. pylori infection. Similar data were seen in the Iranian population, but the opposite was found in the Brunei population . In Malaysia, there was no difference of H. pylori infection between genders in the Kota Kinabalu city and in north‐eastern Peninsular Malaysia .…”

Prevalence of Helicobacter pylori in Southern Part of Iran

“…However, it has been reported that H. pylori prevalence has now started to decline in Asia and the Middle East (26)(27)(28). In a recent study using culturing, Gram staining, and rapid urease test, we reported the H. pylori positivity of 31% in 548 dyspeptic patients of Fars province with both rural and urban nature of lifestyle, Iran, which was surprisingly lower than other local reports (29). Regarding these differences, it can be said that high prevalence of H. pylori infection is related to socioeconomic status, poor living conditions, and poor management of drinking water (30,31).…”

“…The stool Ag positivity of H. pylori was related with age, increasing with age up to 41 -50 years category and then decreasing. Helicobacter pylori is typically acquired in early childhood in developing countries and usually persist during lifetime if left untreated (29), however, the H. pylori infection rate increases with age in adults (32). Although, serum assaying of anti-H. pylori IgG or IgA antibodies could be used to determine prevalence of infection (33), stool antigen test, as a non-invasive test, could be used both safely and cost effectively to screen patients (34,35).…”

Clinical, Endoscopic and Urea Breath Test Among Dyspeptic Patients Referred to Kurdistan Center for Gastroenterology and Hepatology in Sulaimani

“…But in USA by R. P. Jackman, et al [40] was only (10.4%). The reason for the difference in the prevalence of H. pylori positivity is probably due to varying sample size; age groups, geographical locations, socioeconomical factors and time periods the studies were carried out.…”