Prevalence of hepatitis virus types B through E and genotypic distribution of HBV and HCV in Ho Chi Minh City, Vietnam

Tran, Huy; Ushijima, Hiroshi; Quang, Vo Xuan; Phuong, Nguyen Thanh; Li, Tiancheng; Hayashi, Shigeki; Lien, Truong Xuan; Sata, Tetsutaro; Abe, Kenji

doi:10.1016/s1386-6346(03)00166-9

Cited by 78 publications

(92 citation statements)

References 19 publications

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“…Our review found that the reported HBsAg prevalence in general population ranged from 5.7% to 24.7% in Vietnam, with most reporting the prevalence from 10% to 20%. 7,9,10,11,13,17,22 The value was much higher for the indicators of past infection: the anti-HBs ranged from 16% to 40% and anti-HBc from 50% to 75%. 22,10,13 There are an estimated 8.4 million people living with chronic hepatitis B in Vietnam.…”

Section: Overview-hepatitis B and C And Hiv Coinfection In Vietnammentioning

confidence: 97%

“…22 The HBsAg prevalence among the subpopulations was also reported by various studies in Vietnam. The HBsAg prevalence ranged from 8.1% to 17.6% among health care workers and was also high among blood donors, people with liver diseases, people who inject drugs (PWIDs) and female sex workers ([FSWs]; Tables 1 and 2) 22,9,11,23,6,18,14 The available data suggest that hepatitis B virus (HBV) is a major cause of liver disease and liver cancer in Vietnam. Between 30.1% and 87.6% of liver cirrhosis cases and 34.8% and 80% of hepatocellular carcinoma can be attributed to HBV infection.…”

Section: Overview-hepatitis B and C And Hiv Coinfection In Vietnammentioning

confidence: 99%

“…Between 30.1% and 87.6% of liver cirrhosis cases and 34.8% and 80% of hepatocellular carcinoma can be attributed to HBV infection. 10,11,17,22 The vertical and perinatal transmissions are likely the major mode of transmission of hepatitis B in Vietnam. This is suggested by the high HBsAg prevalence in children 7,17,22 and similar prevalence among people of Vietnamese origin living in other countries (Table 1).…”

Section: Overview-hepatitis B and C And Hiv Coinfection In Vietnammentioning

confidence: 99%

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Epidemiology, Responses, and Way Forward

Sereno

Mesquita²,

Kato³

et al. 2012

Journal of the International Association of Physicians in AIDS

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Viral hepatitis is a disease of great concern to public health that is now met by a favorable momentum to combat the global epidemic. This article is intended to highlight the importance of viral hepatitis in the Vietnam population as well in the group of people living with HIV/AIDS (PLWHA). We reviewed available data on epidemiology and response on hepatitis B virus (HBV) and hepatitis C virus (HCV) and HIV coinfection in Vietnam. The hepatitis B surface antigen (HBsAg) prevalence in the general population ranged from 5.7% to 24.7%. The anti-HCV prevalence ranged from 0.38% to 4.3% in the general population, while among people who inject drugs (PWIDs) it ranged from 31% to 97.2%. The HBV prevalence among PLWHA is similar to the general population, while HCV/HIV coinfection is concentrated in some groups. Anti-HCV prevalence among HIV-infected PWIDs can be as high as 98.5%. Developing policies for diagnosis and treatment of chronic HBV and HCV infections are critical priorities in order to prevent clinical progression to cirrhosis and liver cancer.

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Section: Overview-hepatitis B and C And Hiv Coinfection In Vietnammentioning

confidence: 97%

Section: Overview-hepatitis B and C And Hiv Coinfection In Vietnammentioning

confidence: 99%

Section: Overview-hepatitis B and C And Hiv Coinfection In Vietnammentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology, Responses, and Way Forward

Sereno

Mesquita²,

Kato³

et al. 2012

Journal of the International Association of Physicians in AIDS

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“…A national seroepidemiologic survey in 2002 showed that 10-12% of the adult population and 5% of children younger than 5 years were HBsAg positive. Taiwan also has a high rate of HBsAg seroprevalence (10-14%) among its adult population, whereas prevalence rates in the Philippines are 2-16.5%, Vietnam and Thailand 14%, and Southeast Asia, Japan, Korea, and India at a more modest 2-5% [2,3,6,7,9,11,13]. In many developing countries, HBsAg seroprevalence also differs between urban and rural areas.…”

Section: Prevalence Of Chb Among Asian Women Of Childbearing Agementioning

confidence: 99%

“…The rate of HBV infection is estimated to be 36-57% and HBsAg prevalence ranges from 3.8 to 16.8% in Mainland China, with higher rates observed in rural areas [1]. The seroprevalence of HBsAg among adults in other Asian countries has remained similar over the past two decades, ranging from 2 to 20% [2][3][4][5][6][7][8][9][10][11][12][13]. CHB runs an insidious and often progressive course and, when left untreated, can lead to cirrhosis, decompensated liver disease, and hepatocellular carcinoma (HCC) [14].…”

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis B in Asian women of childbearing age

Leung

2009

Hepatol Int

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Hepatitis B virus (HBV) infection is a serious clinical problem affecting approximately 2 billion people worldwide. An estimated 350 million live with chronic hepatitis B (CHB) infection and are at an increased risk for serious liver sequelae and death from acute or chronic consequences of CHB infection. Individuals with CHB have a 20-30% risk of early death from complications, including liver cirrhosis and hepatocellular carcinoma. In the Asia-Pacific region, half of the CHB burden results from vertical or mother-to-child transmission, with early childhood horizontal transmission accounting for the remaining half. Screening and vaccination are key factors in the successful prevention and control of HBV infection. Over the last 20 years, the implementation of screening programs and universal HBV vaccination for all individuals born in endemic areas have reduced the prevalence of HBV infection and HBV-related liver diseases among individuals younger than 30 years. Women of childbearing age are key stakeholders in preventing HBV infection and, as such, play a critical role in reducing the vertical and horizontal transmission of HBV. Further efforts are needed to implement screening and educational programs for women of childbearing age, particularly those with CHB, to prevent the transmission of HBV to newborns, spouses, other household members, and sexual partners. In addition, healthcare workers need to learn how to avoid iatrogenic transmission in the healthcare setting. This article reviews these issues and highlights areas in which their engagement with public health efforts serves to improve quality of life and society as a whole.

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Characteristics of core promoter and precore stop codon mutants of hepatitis B virus in Vietnam

Huy

Ushijima

Quang

et al. 2004

Journal of Medical Virology

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In Asia, genotypes B and C are the most common genotypes of hepatitis B virus (HBV); and genotype C causes more severe liver disease. Core promoter/precore (CP/PC) mutants, known to be linked to these genotypes, could have an impact on the progression and severity of liver disease. Sera of 115 patients, including 39 acute and 76 chronic Vietnamese HBV infected patients, were tested for their liver profile, HBeAg, HBV genotypes, and HBV DNA level. Fragments of 282 nucleotides covering CP/PC were amplified, sequenced, and analysed. In the acute group, CP/PC mutants accounted for 38.4 and 25.6%, respectively. Genotype B was found to be predominant (74.3%, P < 0.05) and linked to the PC mutant (A1896) (P < 0.05). In the chronic group, CP/PC mutants accounted for 61.7 and 32.8%. CP mutants, especially the T1762/A1764 double mutant, were found to correlate with genotype C (81%, P < 0.001), liver cirrhosis, and hepatocellular carcinoma (P < 0.05). Therefore, genotype C in Vietnam, which carried high rate of C-1858 (70%), could play an important role in causing severe chronic liver disease.

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Prevalence of hepatitis virus types B through E and genotypic distribution of HBV and HCV in Ho Chi Minh City, Vietnam

Cited by 78 publications

References 19 publications

Epidemiology, Responses, and Way Forward

Epidemiology, Responses, and Way Forward

Chronic hepatitis B in Asian women of childbearing age

Characteristics of core promoter and precore stop codon mutants of hepatitis B virus in Vietnam

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