Prevalence of high-risk human papillomavirus types 16 and 18 in healthy women with cytologically negative pap smear in Iran

Safaei, Akbar; Khanlari, Mahsa; Momtahen, Moghdeh; Monabati, Ahmad; Robati, Minoo; Amooei, Sedigheh; Valibeigi, Behnaz; Azarpira, Negar

doi:10.4103/0377-4929.72030

Cited by 32 publications

(14 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, HPV 16 and 18 DNA was found in 62.7% and 30.2% of the women, respectively, which is not surprising because the majority of women between 50-59 years of age have been shown to test positive for these HPV types (28). In this study, HPV 16 and 18 DNA was found in the majority of the older women between 30-50 years of age, and this finding is also in agreement with the results of other studies (29,30).…”

Section: Discussionsupporting

confidence: 69%

Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

Zampronha¹,

Freitas‐Junior²,

Murta³

et al. 2013

Clinics

View full text Add to dashboard Cite

OBJECTIVE:This study sought to evaluate the prevalence of human papillomavirus (HPV) types 16 and 18 in women with clinical stage IB cervical cancer treated by radical hysterectomy with pelvic lymphadenectomy as well as to establish a correlation between HPV type and cancer prognosis.METHODS:A single-center cohort study was conducted with 86 patients who had undergone radical hysterectomy for stage I cervical cancer. Prognostic factors and the presence of HPV 16 and 18 were analyzed using a polymerase chain reaction assay. A univariate analysis using Kaplan-Meier curves was conducted to estimate survival.RESULTS:The prevalence of HPV 16 in the study group was 65.3%, and the prevalence of HPV 18 was 33.3%. The prevalence of infection with both viruses was 26.9%. Overall survival at 5 years was 91% among women with HPV 18 and 96% among those without this virus type (p = 0.133). Among the women with HPV 16, the overall survival was 94%, whereas this rate was 96% among those without this virus type (p = 0.663). Disease-free survival was unaffected by the presence of HPV type 16 or 18.CONCLUSION:In the present study, despite the high prevalence of HPV types 16 and 18, the presence of these virus types did not affect the prognosis of patients with stage I cervical cancer who underwent radical hysterectomy.

show abstract

Section: Discussionsupporting

confidence: 69%

Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

Zampronha¹,

Freitas‐Junior²,

Murta³

et al. 2013

Clinics

View full text Add to dashboard Cite

show abstract

“…HPV DNA was identified in 5.7% women who were admitted to different hospitals and gynecological clinics in Tehran [13]. Safaei et al [14] reported positive HPV findings in 5.5% of women who were examined at two gynecological clinics in Shiraz, a city in the southwest of Iran with a population very similar to the population in the current study. Therefore, it seems that the prevalence of HPV infection was very similar in different gynecological clinics in Iran and was comparable to other geographical areas in Muslim and Middle Eastern countries.…”

Section: Discussionmentioning

confidence: 52%

“…Most epidemiological data for HPV infection comes from cross-sectional studies with samples taken from women in different hospitals and gynecological clinics [8-14]. These women had cervical neoplasia or cancer [8-10], abnormal cervical cytology [11-13], and normal Pap smears [10,11,14,15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oncogenic human papillomavirus genital infection in southern Iranian women: population-based study versus clinic-based data

Eghbali

Amirinejad

Obeidi

et al. 2012

Virol J

View full text Add to dashboard Cite

BackgroundEpidemiological studies on genital human papilloma viruses infection (HPVs) in general population are crucial for the implementation of health policy guidelines for developing the strategies to prevent the primary and secondary cervical cancer. In different parts of Iran, there is a lack of population-based studies to determine the prevalence of HPV in the general population. The aim of this population-based study is to compare the prevalence rate of genital HPV infection among reproductive women with our previous clinic-based data, which showed a prevalence rate of 5% in women in southern Iran.ResultsUsing general primers for all genotypes of HPV, of 799 randomly selected women, five (0.63%, 95% CI 0.23-1.55%) tested positive for HPV DNA. Overall, seven different HPV genotypes were detected: six types (16, 18, 31, 33, 51 and 56) were carcinogenic, or “high risk genotypes” and one genotype (HPV-66) was “probably carcinogenic.”ConclusionsIn a population-based study, the prevalence of HPV infection among southern Iranian women was lower than that observed worldwide. However, our gynaecological clinic-based study on the prevalence of HPV infection showed results comparable with other studies in the Middle East and Persian Gulf countries. Since gynaecological clinic-based data may generally overestimate HPV prevalence, estimates of prevalence according to clinic-based data should be adjusted downward by the population-based survey estimates.

show abstract

“…However, compared to studies applying cytological or DNA-based methods for identification of HPVs among healthy women, the rates of HPV types 16 and 18 in the present study were relatively high. Previously, Khodakarami et al from Tehran in 2011, Zandi et al from Bushehr in 2010, and Safaei et al from Shiraz in 2010 reported that the prevalence of HPV types 16 and 18 among healthy Iranian women ranged from 2% -3.1% and 0% -1.5%, respectively (22)(23)(24). Beyond the HPV genotyping methods, different explanations may exist for such differences between our results and those of the mentioned studies, for example the number of asymptomatic patients in our study population.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

Abedini

Karimi

Shamsy

et al. 2016

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Human papillomavirus (HPV) is a DNA virus that establishes productive infections only in keratinocytes of the skin or mucous membranes. Objectives: This study aimed to determine the frequency of two high-risk genotypes of HPV among married and unmarried Iranian women. Materials and Methods:This cross-sectional population-based study consisted of two groups of women: non-married girls referred for premarital counseling, and married women referred for pregnancy diagnosis. Blood samples were evaluated serologically with the ELISA method for HPV types 16 and 18. Results: A total of 177 women (89 single and 88 married) were tested for HPV strains. The frequency of HPV type 16 in single women was significantly higher than in married women (66.3% vs. 40.9%, P < 0.001). The relative frequency of HPV type 18 was also significantly higher in single women than in married women (62.9% vs. 47.7%, P < 0.001). Moreover, HPV type 16 and 18 positivity was significantly associated with higher education levels in single women compared to married women (P < 0.001). Classification of HPV-infected women according to age revealed that the frequency of HPV type 16 was significantly higher in single women aged 25 -35 years compared to married women (P < 0.05). Conclusions:The results showed remarkable rates of high-risk HPV types (16 and 18) in the studied population, which can be a serious alert for public health. This result highlights the potential impact of prophylactic vaccines for future protection against high-risk HPV types in Iranian women.

show abstract

Prevalence of high-risk human papillomavirus types 16 and 18 in healthy women with cytologically negative pap smear in Iran

Abstract: The prevalence of high-risk HPV was highest in the youngest women and gradually decreased with age. Overall, the prevalence of HPV in our population is low.

Cited by 32 publications

References 1 publication

Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

Human papillomavirus types 16 and 18 and the prognosis of patients with stage I cervical cancer

Oncogenic human papillomavirus genital infection in southern Iranian women: population-based study versus clinic-based data

Seroepidemiological Evaluation of High-Risk Human Papillomavirus Types Among Married and Unmarried Iranian Women in Tehran, Iran

Contact Info

Product

Resources

About