Prevalence of human papillomavirus in saliva and cervix of sexually active women

Αδαμοπούλου, Μαρία; Vairaktaris, Eleftherios; Nkenke, Emeka; Avgoustidis, Dimitrios; Karakitsos, Petros; Sioulas, Vasilios; Nisyrios, Themistoklis; Yapijakis, Christos

doi:10.1016/j.ygyno.2013.02.015

Cited by 25 publications

(25 citation statements)

References 56 publications

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“…Adamopoulou et al [11] analyzing DNA samples from the cervix and saliva found the presence of HPV in 58.6% of the saliva samples. Kulkarni et al [10] evaluated two groups: the saliva of patients with and without SCC, thus they found 70.6% and 60.4% of the samples positive for the groups with and without SCC, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Saliva is a body fluid that has been shown to be adequate for the detection of HPV [10,11], and because it is a non-invasive method for collecting material, it can easily be performed in any population. In addition to being easy to obtain saliva, it presents cells of different regions of the oral mucosa, thus facilitating the analysis when seeking HPV, since it is known that HPV presents predilection for certain areas of the oral cavity, such as the oropharyngeal region and tonsillar pillar [11].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to being easy to obtain saliva, it presents cells of different regions of the oral mucosa, thus facilitating the analysis when seeking HPV, since it is known that HPV presents predilection for certain areas of the oral cavity, such as the oropharyngeal region and tonsillar pillar [11]. When analyzing saliva samples from patients with oral SCC, SahebJamee et al [12] found the presence of HPV in 40.9% of the patients and in 25% of the controls.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma HPV DNA is detectable in oral leukoplakia patients

Ferreira

Biasoli

Bernabé

et al. 2017

Pathology - Research and Practice

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma HPV DNA is detectable in oral leukoplakia patients

Ferreira

Biasoli

Bernabé

et al. 2017

Pathology - Research and Practice

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“…Our results, in accordance with the cited studies, highlight the need to perform an oral screening test in the women with cervical high risk-HPV lesions. The correlation between these two anatomic sites could be consequent to genetic predisposition and/or conditions of low immune response such as HIV infection [29, 30] that probably favor the colonization and the persistence of oral HPV [31]. …”

Section: Resultsmentioning

confidence: 99%

Prevalence of human papillomavirus in saliva of women with HPV genital lesions

Visalli

Currò

Facciolà

et al. 2016

Infect Agents Cancer

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BackgroundThe human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwide but studies showed that these viruses can cause numerous cancers in several tissues including Oral Squamous Cell Carcinoma (OSCC). At least 90 % of HPV-positive OSCCs are associated with high-risk (or oncogenic) HPV-16 and oral infection confers an approximate 50-fold increase in risk for HPV-positive OSCC. HPV-positive OSCCs are associated with sexual behaviors in contrast to HPV-negative OSCCs that are associated with chronic tobacco and alcohol use. The aim of this study was to estimate the prevalence of HPV-DNA in saliva samples collected from women in which it has been previously established the HPV infection of the cervix with relative genotyping and, then, to study the possible correlation.MethodsSaliva samples were collected from 100 women with HPV cervical lesions, aged between 22 and 52 years old, and 25 healthy women with normal cytology (control group), aged between 20 and 49 years old. PCR assay was used to detect HPV DNA.ResultsThe prevalence of oral HPV infection in saliva samples was 24 % in women with HPV cervical lesions while in the control group was 8 %. It has been demonstrated a strong association between high grade squamous intraepithelial lesion and oral infection due to HPV16 and 18, that are the most frequently detected HPV genotypes.ConclusionThis study shows that patients with genital HPV infection are at risk for oral infection and, consequently, for the development of OSCC.

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“…A comparison of HPV infection between denture users and non-users demonstrated a higher HPV infection rate in the former, demonstrating that oral mucosal injuries caused by mechanical stimulation of dentures and poor oral hygiene due to unclean dentures were involved in HPV infection [46]. In addition, the oral HPV infection rate is higher in women with HPV-infected cervices, suggesting that HPV infection in the cervix is another risk factor for oral HPV infection [47]. …”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Shigeishi

Sugiyama

2016

J Clin Med Res

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BackgroundOral human papillomavirus (HPV) infection is associated with oral cancer development. However, few epidemiologic investigations have focused on oral HPV prevalence in healthy individuals. The objective of this study was to provide updated information regarding oral HPV prevalence in patients without oral cancer worldwide.MethodsWe systematically reviewed 29 studies reporting the prevalence of oral HPV infection that included 22,756 subjects (10,124 males, 12,623 females, and nine unknown gender; age range 2 - 89 years) and were published from January 2012 to June 2015.ResultsThe prevalence of overall HPV, low-risk type HPV, high-risk type HPV, and HPV16 in the reported cases was 5.5%, 2.2%, 2.7%, and 1.0%, respectively. The prevalence of overall HPV was considerably higher in males who had sex with males (12.2%) as compared to heterosexual males (4.7%) and females (2.9%). A meta-analysis was performed to elucidate significant risk factors for oral HPV infection, which revealed a significant statistical association for oral sex and smoking with oral HPV infection (odds ratio (OR): 1.90, 95% confidence interval (CI): 1.51 - 2.39, P < 0.0001; OR: 2.13, 95% CI: 1.32 - 3.43, P = 0.002).ConclusionsOur findings suggest that sexual behavior and smoking are importantly related to oral HPV infection in healthy individuals.

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Prevalence of human papillomavirus in saliva and cervix of sexually active women

Cited by 25 publications

References 56 publications

Plasma HPV DNA is detectable in oral leukoplakia patients

Plasma HPV DNA is detectable in oral leukoplakia patients

Prevalence of human papillomavirus in saliva of women with HPV genital lesions

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

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