Prevalence of Human Papillomavirus Infection and Associated Risk Factors in Young Women in Brazil, Canada, and the United States

Roteli-Martins, Cecília Maria; Carvalho, Newton Sérgio de; Naud, Paulo; Teixeira, Júlio César; Borba, Paola Colares de; Derchain, Sophie; Tyring, Stephen K.; Gall, Stanley A.; Díaz, Ángela; Blatter, Mark M.; Shier, R. Michael; Romanowski, Barbara; Quint, Wim; Issam, Jamiai; Galindo, Claudia; Schuind, Anne; Dubin, Gary

doi:10.1097/pgp.0b013e3181f38dfe

Cited by 33 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a previous study with 1,509 Brazilian healthy young women without cervical lesions of five different centres, aged 15 to 25 years, we found an overall prevalence of HPV of 29.7%. The most prevalent HPV type was HPV16, followed by HPV51, 52, 31 and 68 [19]. Among 8,656 healthy Danish women aged 20 to 29 years, the prevalence of HPV types in decreasing rank was HPV16 followed by HPV31, 52, 51, 33, 39, 45 and 56 [10].…”

Section: Discussionmentioning

confidence: 99%

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundCervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neoplasia. Currently, over 100 HPV types have been identified, but HPV16 and 18 are recognized as the mayor culprits in cervical carcinogenesis. Our objective was to assess the relationships between single- (ST) and multiple-type (MT) HPV infections with patients’ age and lesion pathological status.Methods328 patients with either squamous or glandular intraepithelial or invasive cervical lesion were selected. All subjects were tested for HPV genotypes with reverse hybridization for 21 high- (hr-HPV) and 16 low-risk (lr-HPV) probes. Prevalence of ST and MT HPV infections was compared across histological types and age strata.Results287 (87%) women had at least one HPV type detected and 149 (52%) had MT infections. The most prevalent HPV type was HPV16, present in 142 cases (49% of all HPV-positive cases), followed by HPV58, 52, 31, 35 and 33. HPV18, in single or multiple infections, occurred in 23 cases (8% of hr-HPV cases). Almost all glandular lesions were associated with HPV16 and 18 alone. Multiple infections were significantly more prevalent in squamous than in glandular lesion for HPV16 and 18 (P = 0.04 and 0.03 respectively). The prevalence of MT infections followed a bimodal distribution; peaking in women younger 29 years and in those aged 50 to 59.ConclusionsOur data indicate that prevention strategies for pre-invasive and invasive squamous lesions should be focused on HPV16 and a few alpha-9 HPV types. It is clear to us that in young women, prophylaxis must cover a large amalgam of HPV types beyond classic HPV16 and 18.

show abstract

Section: Discussionmentioning

confidence: 99%

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…A limitation of this study is that no additional information from the South African women is known about their sexual behavior, and therefore we were unable to explore associations between behaviors and HPV genotype. Roteli-Martins et al found that young age at first sexual intercourse and increasing number of sexual partners is the main determinant for hr-HPV 16/18 infections [17]. …”

Section: Discussionmentioning

confidence: 99%

HPV Type Distribution and Cervical Cytology among HIV-Positive Tanzanian and South African Women

Dols

Reid

Brown

et al. 2012

ISRN Obstetrics and Gynecology

Self Cite

View full text Add to dashboard Cite

Background. There are limited data on high-risk human papillomavirus (hr-HPV) genotypes among HIV-positive women in Africa, and little is known about their relationship with cervical cytology in these populations. Methods. We conducted a cross-sectional study among 194 HIV-positive women (143 from Tanzania, and 51 from South Africa) to evaluate HPV genotypes among HIV-positive women with normal and abnormal cytology. Cervical samples were genotyped for HPV types, and slides were evaluated for atypical squamous cell changes according to the Bethesda classification system. Results. Prevalence of high grade squamous intraepithelial dysplasia (HSIL) was 9%. Overall, more than half (56%) of women were infected with an hr-HPV type; 94% of women with HSIL (n = 16), 90% of women with LSIL (n = 35), and 42% of women within normal limits (WNL) (n = 58) tested positive for hr-HPV. Overall, the most prevalent hr-HPV subtypes were HPV16 (26%) and HPV52 (30%). Regional differences in the prevalence of HPV18 and HPV35 were found. Conclusion. Regional differences in HPV genotypes among African women warrant the need to consider different monitoring programmes for cervical preneoplasia. HPV-based screening tests for cervical preneoplasia would be highly inefficient unless coupled with cytology screening of the HPV-positive sample, especially in HIV-positive women.

show abstract

“…A meta-analysis has revealed that HPV 16 is the most common genotype found among women presenting with normal cervical cytology worldwide (de Sanjosé et al, 2007). Furthermore, a multicenter analysis of young women presenting with normal cervical cytology from Brazil, Canada, and the USA also determined HPV 16 to be the most prevalent genotype (Roteli-Martins et al, 2011). In Brazil, this type was also found to be the most prevalent, ranging from 18.6 to 52.2% within the women population in different cities (Rosa et al, 2008;Oliveira et al, 2010;Castro et al, 2011;Baldez da Silva et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil

Coser¹,

T²,

Simon³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Human papillomavirus (HPV) infection is a common viral sexually transmitted infection and the main cause of cervical cancer in women worldwide. Epidemiological data on the prevalence of HPV in a given population is essential for the establishment of effective prevention strategies. The aim of this study was to determine HPV prevalence in women who attended a public health service within an urban center in Brazil. Cervical samples were collected from 337 women recruited from a primary public health care clinic in the city of Cruz Alta located in Rio Grande do Sul, the were detected in 83 (72.8%) and 48 (42.1%) samples, respectively. Furthermore, a great diversity of HPV genotypes was observed (18 high-risk, 12 low-risk, and 1 indeterminate). The most commonly identified low-risk types were candHPV62 (7.9%) and 61 (5.3%), while the most common high-risk types were 16 and 33 (8.8% each). Abnormal cytology was observed in 10 (3.0%) women, 9 of which were infected with HPV. Of the remaining 327 women with normal cytology results, 107 (32.7%) were positive for HPV DNA. HPV infection was correlated with younger age (less than 40 years), a first Pap smear, and other vaginal infections.

show abstract

Prevalence of Human Papillomavirus Infection and Associated Risk Factors in Young Women in Brazil, Canada, and the United States

Cited by 33 publications

References 0 publications

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions

HPV Type Distribution and Cervical Cytology among HIV-Positive Tanzanian and South African Women

Prevalence and genotypic diversity of cervical human papillomavirus infection among women from an urban center in Brazil

Contact Info

Product

Resources

About