Prevalence of Nasal Colonization Among Patients With Community-Associated Methicillin-Resistant<i>Staphylococcus aureus</i>Infection and Their Household Contacts

Zafar, Uzma; Johnson, Leonard B.; Hanna, Michel M.; Riederer, Kathleen; Sharma, Mamta; Fakih, Mohamad G.; Thirumoorthi, Muthayipalayam C.; Farjo, Rand S.; Khatib, Riad

doi:10.1086/518965

Cited by 51 publications

(52 citation statements)

References 17 publications

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“…A recent study reported 19% MRSA transmission to household contacts from index persons treated in home health care settings (23). Most studies reporting on MRSA transmission from index persons to household members differ in study methods, and therefore, comparison of study outcomes with that of our study cannot yield robust conclusions (14,15,22,23,36). These studies differ mostly in the sites cultured.…”

Section: Discussionmentioning

confidence: 72%

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Transmission of Methicillin-Resistant Staphylococcus aureus to Household Contacts

et al. 2010

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The frequency of and risk factors for methicillin-resistant Staphylococcus aureus (MRSA) transmission from a MRSA index person to household contacts were assessed in this prospective study. Between January 2005 and December 2007, 62 newly diagnosed MRSA index persons (46 patients and 16 health care workers) and their 160 household contacts were included in the study analysis. Transmission of MRSA from an index person to household contacts occurred in nearly half of the cases (47%; n ‫؍‬ 29). These 29 index persons together had 84 household contacts, of which two-thirds (67%; n ‫؍‬ 56) became MRSA positive. Prolonged exposure time to MRSA at home was a significant risk factor for MRSA transmission to household contacts. In addition, MRSA colonization at least in the throat, younger age, and eczema in index persons were significantly associated with MRSA transmission; the presence of wounds was negatively associated with MRSA transmission. Furthermore, an increased number of household contacts and being the partner of a MRSA index person were householdrelated risk factors for MRSA acquisition from the index person. No predominant pulsed-field gel electrophoresis (PFGE) type was observed to be transmitted more frequently than other PFGE types. To date, screening household contacts and providing MRSA eradication therapy to those found positive simultaneously with the index person is not included in the "search-and-destroy" policy. We suggest including both in MRSA prevention guidelines, as this may reduce further spread of MRSA.

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Section: Discussionmentioning

confidence: 72%

“…The spread of MRSA among household contacts has been reported previously, but the observed MRSA transmission rates to household contacts are variable (5,14,16,18,22,23,36). Johansson et al (18) observed that in 22 of 51 index persons (43%), MRSA was transmitted to one or more household contacts.…”

Section: Discussionmentioning

confidence: 89%

Transmission of Methicillin-Resistant Staphylococcus aureus to Household Contacts

et al. 2010

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“…2,22 Proper hand hygiene (Box 1), 8 as well as cleaning of equipment and the environment, is important in both the home and institutions where health care is provided. In the home, it is neither realistic nor practical to attempt to isolate a family member who is colonized or infected with MRSA.…”

Section: Prevention and Controlmentioning

confidence: 99%

“…Antimicrobial resistance may also evolve or be acquired in the community and be introduced into a health care facility from the community, where the infection can spread widely. [1][2][3][4][5][6] The suggestions presented in this review provide a basic approach that can be applied to prevent the transmission of current antimicrobial-resistant pathogens and those that may arise in the future.…”

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confidence: 99%