Prevalence of Osteoporosis in Relation to Serum Calcium and Phosphorus in Aging Women

Shakoor, Sadaf; Ilyas, Fasiha; Abbas, Naheed; Mirza, Muhammad Aslam; Arif, Sana

doi:10.17957/jgiass/2.2.511

Cited by 6 publications

(7 citation statements)

References 44 publications

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“…Indumati et al and Prabha et al found that osteoporotic patients had normal or low serum calcium. The increase in alkaline phosphatase levels in osteoporosis results from hormonal variations . In our osteoporotic patients, phosphorus and alkaline phosphatase levels were significantly higher which is in agreement with Gallagher et al and Prabha et al results.…”

Section: Discussionsupporting

confidence: 93%

“…In contrary to our results, Hedley et al detected a relation between age and gain of weight and explained this by the effect of increasing age on the decrease of metabolic rate inducing fat formation and deposition. Shakoor et al reported nonsignificant correlation between BMI and osteoporosis. Additionally, Asomaning et al detected that BMI and BMD were inversely correlated.…”

Section: Discussionmentioning

confidence: 99%

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Insight into the possible role of miR‐214 in primary osteoporosis via osterix

Mohamad

Nabih

Zakaria

et al. 2019

J of Cellular Biochemistry

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Osteoporosis is a bone disease characterized by chronic pain and recurrent fractures. Osterix is a transcription factor regulating bone formation. miR‐214 was found to have a role in skeletogenesis. Our goal was to investigate the possible role of miR‐214 in primary osteoporosis through osterix. Their expression was determined in bone samples obtained from primary osteoporotic patients (n = 26) and age‐ and sex‐matched controls (n = 14). Additionally, their expression was correlated to the laboratory and clinical parameters of the study participants. Differential expression of osterix and miR‐214 was detected in the osteoporotic group compared to controls. While miR‐214 was significantly higher, osterix was significantly lower. In primary osteoporotic patients, relative quantification value of osterix was positively correlated with sex, body mass index, and ionized calcium and negatively correlated with miR‐214 and C‐reactive protein. Thus, the role of miR‐214 in primary osteoporosis could be through inhibiting osterix expression in bones and therefore both miR‐214 and osterix could be targets for future therapeutic intervention.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Insight into the possible role of miR‐214 in primary osteoporosis via osterix

Mohamad

Nabih

Zakaria

et al. 2019

J of Cellular Biochemistry

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“…This agrees with other studies observing that serum calcium levels are typically maintained between 8.5 and 10.5 mg/dl, which is a constrained range. Serum calcium concentrations, however, are just 0.1 to 0.2 percent of extracellular calcium, or just 1% of the total body calcium [19] Shakoor, Sadaf, et al (2014). As a result observed were high significant patients osteoporosis and control, serum calcium levels are a poor indicator of the total amount of calcium.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Osteocalcin and Some Biochemical Marker in Diabetes Mellitus Iraqi Women's patients with Osteoporosis

Jafer¹,

Ali²

2023

IHJPAS

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Diabetes mellitus is a set of metabolic diseases, the most prevalent of which is chronic hyperglycemia. The culprits include insulin synthesis, insulin action, or both. Osteoporosis is a progressive systemic skeletal disorder defined by decreased bone mass and micro architectural degeneration of bone tissue, resulting in increased bone fragility and fracture risk, according to the World Health Organization (WHO). The degree of Nervosa damage determines how much a diabetic patient's body has been compromised. The current study's goal is an estimation: Age, BMI, FBS, HbA1C, D3, ALP, Ca, P, and Osteocalcin in Iraqi T2DM Women's patients with and without Osteoporosis. Three vitamins are required for Osteocalcin biosynthesis: vitamin K for Gla formation, vitamin C for hydroxylation of Pro-9 to hydroxyproline, and vitamin D for Osteocalcin production stimulation. Vitamin D is known to function in calcium homeostasis and bone metabolism. Osteocalcin is a hormone produced by osteoblasts and secreted into the extracellular matrix of bone and the bloodstream. It serves as a biological marker for bone formation. The work was classified into three groups. G1 (n= 40) is the control set that went to the Iraqi Ministry of Health's Endocrinology and Diabetes Center in Baghdad. G2 (n= 40) are patients with type 2 diabetes mellitus without Osteoporosis who visited the Endocrinology and Diabetes Center of the Iraqi Ministry of Health in Baghdad, and G3 (n= 40) are patients with type 2 diabetes Mellitus with Osteoporosis.

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“…However, previous studies showed a significant relationship; increasing serum phosphorus level and the subsequent increase in PTH level have destructive effects on bone mass. 59,60 Correlations (OR) analyses suggested that normal BMI, older age, longer dialysis duration, female gender, DM and low serum Vitamin D could be potentially stronger risk factors compared to the other factors studied. However logistic regression (backward) analysis revealed that age, dialysis duration and BMI remained significantly associated with bone mass status.…”

Section: Ipth and Bone Mass Statusmentioning

confidence: 99%

Assessment of Bone Mineral Density in Patients Undergoing Hemodialysis; An Iranian Population-Based Study

et al. 2021

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Background: End-stage renal disease (ESRD) is a condition in which bone turnover and metabolism is impaired; thus, osteoporosis and low bone density are subsequently inevitable. We aimed to determine bone mineral density (BMD) and biochemical markers, and associated factors in hemodialysis (HD) patients. Methods: Patients aged 30-70 years undergoing HD between 2015 to 2019 were enrolled in this cross-sectional study. BMD measured by dual energy x-ray absorptiometry (DEXA) and biochemical laboratory tests were assessed in 200 patients undergoing HD. Statistical analysis was based on t test, Pearson, regression and Mann-Whitney tests using SPSS 16. Results: Two hundred patients were investigated. Sixty percent of the patients were female. Mean ± SD of participants’ age was 58.6 (±11.63) years and mean ± SD for duration of HD was 45.69 (± 43.76) months. Osteoporosis was found in 48% (n=96) and low bone density in 36% (n=76) of our patients. General osteoporosis was more frequent in those undergoing HD for more than 3 years, although not significantly (P=0.093, odds ratio [OR]=0.37). However, regional osteoporosis in hip and femoral neck, but not spine vertebrae, were significantly higher after three years of HD (P=0.036, OR=0.27; P=0.042, OR=0.27; and P=0.344, OR=0.56, respectively). Increased body mass index (BMI) correlated negatively with osteoporosis (P=0.050). Conclusion: With increasing age and duration of HD, BMD decreases. Higher BMI was associated with higher bone mass density. Bone density assessment seems to be necessary in patients undergoing HD.

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Prevalence of Osteoporosis in Relation to Serum Calcium and Phosphorus in Aging Women

Cited by 6 publications

References 44 publications

Insight into the possible role of miR‐214 in primary osteoporosis via osterix

Insight into the possible role of miR‐214 in primary osteoporosis via osterix

Evaluation of Osteocalcin and Some Biochemical Marker in Diabetes Mellitus Iraqi Women's patients with Osteoporosis

Assessment of Bone Mineral Density in Patients Undergoing Hemodialysis; An Iranian Population-Based Study

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