Prevalence of parkinsonism and Parkinson disease in urban and rural populations from Latin America: A community based study

Llibre‐Guerra, Jorge J.; Prina, Matthew; Sosa, Ana Luisa; Acosta, Daisy; Jiménez‐Velázquez, Ivonne Z.; Guerra, Mariella; Llibre-Guerra, Juan C; Valvuerdi, Adolfo; Peeters, Geeske; Ziegemeier, Ellen; Acosta, Isaac; Tanner, Caroline M.; Juncos, Jorge L.; Rodríguez, Juan J. Llibre

doi:10.1016/j.lana.2021.100136

Cited by 18 publications

(23 citation statements)

References 61 publications

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“…Historically, Hispanics have been underrepresented in both PD 15 and genomic research 16 even as PD genetic testing increases in the U.S. and globally. This cross-sectional, mixed-methods study aimed to assess general and PD genetics knowledge, attitude toward genetic testing, and interest in genetic testing and counseling among a group of Hispanics in the DR, where the prevalence of PD was recently estimated to be 2.1% 14 .…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, no studies have focused on Hispanics within Latin America, or even more broadly across Hispanics living in the U.S. The primary aim of this crosssectional, mixed-methods study was to assess these factors in Hispanic PwP and their at-risk relatives in the Dominican Republic (DR) where access to clinical genetic services is limited 13 despite the prevalence of PD being 2.1% among this population 14 . An understanding of this population's knowledge, attitudes, and interests could further emphasize the need for clinical genetic services in the DR and inform culturally tailored genetic counseling as the profession expands to this region.…”

Section: Introductionmentioning

confidence: 99%

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Readiness for Parkinson's Disease Genetic Testing and Counseling in Patients and Their Relatives in the Dominican Republic

Hodges

Hackl

Cook

et al. 2023

Preprint

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Genetic testing for Parkinson’s disease (PD) is increasing globally, and genetic counselors serve as a resource to provide information about PD and genetic testing. However, genetic counseling is not yet recognized as an independent profession in most of Latin America and, despite PD having the highest incidence among Hispanic populations, studies have found that Hispanic individuals are underrepresented in PD and genomic research. Understanding what Hispanic individuals know about PD, genetic testing for PD, and their interest in speaking with a genetic counselor is crucial when assessing readiness for genetic testing and counseling. In this cross-sectional study, a mixed-methods survey was distributed to people with Parkinson’s disease (PwP) and their unaffected biological relatives in the Dominican Republic (DR). Survey questions assessed genetics knowledge, attitude toward genetic testing, and interest in genetic testing and counseling. Most participants (69%) scored the maximum on the attitude scale, indicating an overall positive attitude toward genetic testing. Furthermore, 95% indicated interest in genetic testing for PD, and 98% were at least somewhat interested in meeting with a genetic counselor. The mean PD genetics knowledge score was similar to previously published data. Through free responses, participants expressed a desire to know more about PD treatment and management, prevention, cause, and their personal risk for PD. These results emphasize the importance of building genetic testing and counseling capacities in low- and middle-income Hispanic countries like the Dominican Republic.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Readiness for Parkinson's Disease Genetic Testing and Counseling in Patients and Their Relatives in the Dominican Republic

Hodges

Hackl

Cook

et al. 2023

Preprint

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“…The sample size of 31 was obtained with a 2% prevalence of PD, a confidence interval of 95%, and a 5% margin of error. 6 After obtaining the institutional ethical committee approval (ECR/270/Inst./20022014), Thirty patients with idiopathic PD and 30 healthy volunteers were included in the study. Patients with Parkinson’s plus syndrome, conductive hearing loss, tinnitus, and patients on labyrinthine sedatives were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

Association of Cervical Vestibular-Evoked Myogenic Potentials (VEMP) and Postural Instability in Patients with Parkinson’s Disease: A Cross-Sectional Study

Gaur

Rajamanickam

Chinnathambi

et al. 2022

Annals of Neurosciences

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Background Postural instability is a common problem in patients with Parkinson’s disease (PD). The appropriate cooperation of vestibular, visual, and proprioceptive signals along with apt anticipatory and adaptive postural responses is essential for postural stability. Abnormalities in this sensorimotor admixture lead to postural instability in PD. The function of vestibular otolith function and its central connections in postural instability of PD is still obscure. Cervical vestibular-evoked myogenic potentials (VEMP) can be used to assess the function of the saccular part of otolith and its connections. Purpose We aimed to study the role of dysfunction of the saccule and its connections at the brainstem by comparing the VEMP with normal controls and correlating it with the postural instability in patients with PD. Methods Thirty patients with PD and 30 healthy volunteers were included in the study, after obtaining the institutional ethical committee approval. Patient’s demographic data, stage and duration of illness, treatment history, history of fall, postural instability, Unified Parkinson’s Disease Rating Scale (UPDRS) score, and Non-Motor Symptoms Scales (NMSs) were noted. Cervical VEMP analysis was done for both patients and controls. Results and Conclusion Patients with absent VEMP had significant postural instability, a history of falls, and a high UPDRS score. Mean P13 and N23 latencies were prolonged, and the amplitude was significantly low in patients with PD. Absent cVEMP was significantly associated with postural instability, non-motor symptoms, especially gastrointestinal, miscellaneous symptoms, and mood/cognition. VEMP can be considered an early electrophysiological marker for dysfunction of otolith and its central connections.

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“…A DP é a principal desordem do movimento e segunda doença neurodegenerativa mais comum no mundo, afetando cerca de 1-3% da população acima de 60 anos do mundo (WHO, 2020;LLIBRE-GUERRA et al, 2022). Devido a sua heterogeneidade, com influência de fatores genéticos, ambientais e comportamentais, além de ser subdiagnosticada principalmente em países de baixa renda, é difícil estabelecer uma base epidemiológica completa sobre a doença, a qual varia em cada região e cultura (ASCHERIO; SCHWARZSCHILD, 2016).…”

Section: Revisão Bibliográficaunclassified

Estimulação cerebral profunda como tratamento na doença de Parkinson

Rodrigues¹,

Neto²,

Souza³

et al. 2022

Braz. J. Hea. Rev.

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O presente trabalho teve como objetivo detalhar a utilização da estimulação cerebral profunda (ECP) como estratégia terapêutica no tratamento da doença de Parkinson (DP) avançada. O diagnóstico da DP tem crescido de forma alarmante nas últimas décadas, sendo, atualmente, a principal desordem do movimento e segunda doença neurodegenerativa mais comum no mundo. O tratamento farmacológico para essa doença é bem estabelecido, porém ineficaz ou insuficiente em algumas situações. Nessas condições, outros métodos terapêuticos para tratar as complicações motoras são indicados, entre eles a ECP, que é uma forma de neuromodulação onde eletrodos, conectados a um gerador de pulso, são cirurgicamente implantados em alvos específicos do cérebro permitindo a articulação dos padrões de condução do potencial de ação dos neurônios até determinadas regiões. Trata-se de um recurso terapêutico seguro e efetivo, melhorando disfunções motoras e reduzindo tremores, além de permitir o ajuste adequado para cada indivíduo, restringindo os efeitos colaterais associados à medicação. Ainda, assim, o desenvolvimento de mais pesquisas sobre o tema é de grande importância de forma a tornar esse tratamento mais acessível, com maior previsibilidade no longo prazo, além de reduzir os principais riscos associados.

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Prevalence of parkinsonism and Parkinson disease in urban and rural populations from Latin America: A community based study

Cited by 18 publications

References 61 publications

Readiness for Parkinson's Disease Genetic Testing and Counseling in Patients and Their Relatives in the Dominican Republic

Readiness for Parkinson's Disease Genetic Testing and Counseling in Patients and Their Relatives in the Dominican Republic

Association of Cervical Vestibular-Evoked Myogenic Potentials (VEMP) and Postural Instability in Patients with Parkinson’s Disease: A Cross-Sectional Study

Estimulação cerebral profunda como tratamento na doença de Parkinson

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