Prevalence of silent prostatic adenocarcinoma in 165 patients undergone cystoprostatectomy: A retrospective study

Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

“…Unsuspected prostate cancer in radical cystoprosatectomy specimens were shown to generally involve small lesions localized within the prostate [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The present study also confirmed this finding; that is, incidentally detected prostate cancer was regarded as having more favorable characteristics in terms of serum PSA, pathological stage, Gleason score, perineural invasion and capsular penetration than clinically detected prostate cancer.…”

“…In this series, incidental prostate cancers were found in 12.3% of cystoprostatectomy specimens, which was remarkably low compared with those in previous studies from Western countries; that is, when the outcomes of 18 studies summarized in Table 3 were combined, the proportion of incidental prostate cancer in Western countries appeared to be 28.0% [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Considering the well-established finding that the incidence of latent prostate cancer in Japan is similar to that in Western countries [22], these outcomes suggest that different mechanisms are involved in the development of incidental and latent cancers in Japanese and Western men.…”

“…The present study also confirmed this finding; that is, incidentally detected prostate cancer was regarded as having more favorable characteristics in terms of serum PSA, pathological stage, Gleason score, perineural invasion and capsular penetration than clinically detected prostate cancer. Furthermore, in this series, 29.0% of incidental prostate cancers were judged to be insignificant cancer; however, various proportions of insignificant prostate cancer in cystoprostatectomy specimens were reported in previous studies, ranging from 7 to 60%, which may reflect several methodological differences among these studies, such as the definition of insignificant disease and sectioning interval of resected specimens [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. It is of interest to investigate the prognostic significance of incidental prostate cancer.…”

“…These latent cancers are usually small, well or moderately differentiated, and localized within the prostate. In general, the majority of prostate cancers detected in the prostate of cystoprostatectomy specimens from patients undergoing bladder cancer surgery have also been regarded as clinically insignificant disease [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Therefore, analyzing cystoprostatectomy specimens, which offer a unique opportunity to study the incidence and morphological features of incidental prostate cancer, would be an interesting approach to characterize differences between incidentally and clinically detected prostate cancers.…”

Incidentally detected prostate cancer in cystoprostatectomies: pathological and morphometric comparison with clinically detected cancer in totally embedded specimens

“…Removal of the prostate with the bladder during radical cystectomy for bladder cancer provides a unique opportunity to evaluate the clinical and morphological features of incidentally detected prostate cancer [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. To our knowledge, there are no previous studies that compare the morphological, morphometric, and immunohistochemical features of benign prostate, high-grade prostatic intraepithelial neoplasia (PIN), and cancer in cystoprostatectomy and radical prostatectomy specimens; this was the aim of the current study.…”