Prevalence of thiamine deficiency in heart failure patients on long-term diuretic therapy

Possible involvement of thiamine insufficiency in heart failure in the institutionalized elderly

“…(5) On the contrary, a cross-sectional study showed that there was no difference in the thiamine level between patients on loop diuretics and controls. (6) Such discrepancy is probably due to the difference in the dosage and characteristics of subjects, and further studies are needed.…”

“…Recently, however, papers from abroad have been published concerning the relationship between thiamine and diuretic therapy in patients with heart failure. (5)(6)(7)(8)(9) Since thiamine does not have specific binding proteins, it is easily filtered in glomeruli and excreted in the urine, and the use of diuretics further leads to excessive loss of thiamine. (10) Moreover, bodily storage of thiamine is quite limited.…”

Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients with Heart Failure? A Focused Review

“…Speculation exists that bumetanide and torsemide also may produce thiamine deficiency, but studies specifically focusing on the effects of these drugs on body thiamine status are lacking. 23 It is certainly possible that thiamine deficiency in patients with heart failure treated with loop diuretics is not unique to furosemide.…”